Abstract：
:Stem cell is defined by its ability to self-renewal and generates differentiated functional cell types, which are derived from the embryo and various sources of postnatal animal. These cells can be divided according to their potential development into totipotent, unipotent, multipotent andpluripotent. Pluripotent is considered as the most important type due to its advantageous capability to create different cell types of the body in a similar behavior as embryonic stem cell. Induced pluripotent stem cells (iPSCs) are adult cells that maintain the characteristics of embryonic stem cells because it can be genetically reprogrammed to an embryonic stem cell-like state via express genes and transcription factors. Such cells provide an efficient pathway to explorehuman diseases and their corresponding therapy, particularly, neurodevelopmental disorders. Consequently, iPSCs can be investigated to check the specific mutations of neurodegenerative disease due to their unique ability to differentiate into neural cell types and/or neural organoids. The current review addresses the different neurodegenerative diseases model by using iPSCs approach such as Alzheimer's diseases (AD), Parkinson diseases (PD),multiplesclerosis(MS) and psychiatric disorders. We also highlight the importance of autophagy in neurodegenerative diseases.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Amin N,Tan X,Ren Q,Zhu N,Botchway BOA,Hu Z,Fang Mdoi
10.1016/j.pnpbp.2019.109674subject
Has Abstractpub_date
2019-12-20 00:00:00pages
109674eissn
0278-5846issn
1878-4216pii
S0278-5846(19)30230-1journal_volume
95pub_type
杂志文章,评审abstract：:Schizophrenia is a disorder associated with cortical inhibition deficits. Transcranial direct current stimulation (tDCS) induces changes in cortical excitability in healthy subjects and individuals with neuropsychiatric disorders depending on the stimulation parameters. Our aim was to investigate whether a previously ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pnpbp.2018.11.004
更新日期：2019-03-02 00:00:00
abstract：:Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneo...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.05.008
更新日期：2018-08-30 00:00:00
abstract：:Deficits in decoding and understanding facially expressed emotions occur commonly in persons with autism spectrum disorder (ASD), which contribute to the impairment of social communication that serves as one of its core diagnostic criteria. Research suggests that abnormalities of visual scanning of the face, activatio...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2018.05.009
更新日期：2019-01-10 00:00:00
abstract：:1. Genetic databases are an expanding and readily accessible repository of information on the mapping and sequencing of the human genome, and that of other model organisms. The integration and application of this information to neuropsychiatric disease is illustrated using neuroendocrine and neuropharmacologic data, c...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(91)90078-f
更新日期：1991-01-01 00:00:00
abstract：:Higher impulsivity observed in alcoholics is thought to be due to neurocognitive functional deficits involving impaired inhibition in several brain regions and/or neuronal circuits. Event-related oscillations (EROs) offer time-frequency measure of brain rhythms during perceptual and cognitive processing, which provide...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2015.10.002
更新日期：2016-02-04 00:00:00
abstract：:Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixe...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.05.015
更新日期：2018-08-30 00:00:00
abstract：:Individuals may develop fear extinction deficits after life-threatening traumatic events; such deficits indicate posttraumatic stress disorder (PTSD). Because the occurrence of this disorder differs among people who have experienced trauma, hidden underlying factors should be determined. Increasing evidence suggests t...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.109914
更新日期：2020-07-13 00:00:00
abstract：BACKGROUND:Patients with remitted major depressive disorder (rMDD) generally rely on maladaptive coping strategies for stressful situations. These maladaptive copings are associated with an elevated relapse risk of rMDD; however, their neural basis remains poorly understood. METHODS:We enrolled (1) 45 patients with rM...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.110085
更新日期：2020-09-02 00:00:00
abstract：:We explored whether the elevation of RBC-choline and choline ratio (RBC-choline/plasma-choline) by lithium is a specific effect of lithium, whether these choline parameters are characteristics of the individual patient, and whether they are related to prophylactic lithium response. In lithium-treated patients RBC-chol...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(87)90062-5
更新日期：1987-01-01 00:00:00
abstract：:Organic cation transporter 2 (OCT2) and 3 (OCT3) are low-affinity, high-capacity transporters (uptake-2) expressed in the central nervous system (CNS) and other major organs. Proven to be essential components in the CNS functions, OCT2 and OCT3 are suggested as potential targets of antidepressant therapeutics recently...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2013.11.005
更新日期：2014-03-03 00:00:00
abstract：OBJECTIVES:The objectives of this study were: (1) to investigate, in a clinical practice setting, the effectiveness of olanzapine in the treatment of schizophrenia among partially-responding, symptomatic Asian patients who switch from conventional antipsychotic treatment, (2) to assess the safety of olanzapine and (3) ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.pnpbp.2006.06.006
更新日期：2007-01-30 00:00:00
abstract：:1. The authors attempted to detect a possible effect of treatment with phenelzine on a physiological response to nicotine in the rat. 2. Positive findings in an animal model suggest the feasibility of more complicated experiments in animals and the possibility of studies involving human subjects. 3. Treatment of Sprag...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(93)90065-z
更新日期：1993-09-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is characterized by repetitive behaviors, impaired social communication and stereotyped interests, and often associated with dysregulations in innate/adaptive immune cells. IL-17A has been linked with abnormal behavioral patterns observed in autistic children and animal models of autism....
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.12.002
更新日期：2019-03-02 00:00:00
abstract：:Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2012.06.022
更新日期：2013-12-02 00:00:00
abstract：:Despite considerable efforts and successes investigating the function of the hippocampal formation in memory processes, there are still numerous elusive key issues. Some of them will be addressed in this review. We will argue that recent evidence supports hippocampal participation in several memory processes, such as ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0278-5846(01)00153-1
更新日期：2001-05-01 00:00:00
abstract：:We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatmen...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.05.022
更新日期：2018-08-30 00:00:00
abstract：:A great number of clinical observations show a relationship between epilepsy and depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic basis. The review provides evidence that WAG/Rij rats can be regarded as a valid genetic animal model of absence epilepsy with comorbidity of depressio...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2010.11.010
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Birth months have been shown to affect susceptibility to schizophrenia and other mental disorders, thus this factor could also affect predisposition to delinquency through biological effects on brain development and personality and/or through relative age effects at school. This study aimed to examine the re...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.07.003
更新日期：2008-01-01 00:00:00
abstract：:Our objective was to examine the association between antipsychotic receptor binding profiles and the magnitude of common side-effects. We used regression analysis to examine the association between the receptor binding affinities of antipsychotic agents (log Ki) and degree of specific antipsychotic side-effects. Data ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.01.023
更新日期：2018-06-08 00:00:00
abstract：:Acceleration of blood leukocyte apoptosis in major depression has been described. The present studies have been undertaken to estimate the level of apoptosis of blood leukocytes in patients with depression and to examine the mechanisms leading to apoptosis. Blood was taken from 29 patients with depression (age 48.2+/-...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.11.012
更新日期：2008-04-01 00:00:00
abstract：:A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine,...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(01)00249-4
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Abnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; however, the underlying mechanisms remain uncertain. This study characterized plasma levels and affinities of OT- and VP-reactive autoantibodies (a...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2010.09.021
更新日期：2011-01-15 00:00:00
abstract：:1. This study examines the effects of exercise training and chronic ethanol consumption on cholinesterase activity and its relationship to lipid peroxidation in blood and brain regions of rat. 2. Exercise training (6.5 weeks) decreased acetylcholinesterase (AChE) activity significantly (64% of control) in hypothalamus...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(98)00013-x
更新日期：1998-02-01 00:00:00
abstract：:Gender differences in various clinical features of schizophrenia have been noted and estrogen has been regarded to play important roles. A few previous studies on the association between estrogen receptor (ER) genotypes and schizophrenia focused mainly on ER α gene but failed to report consistent results. The present ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.09.012
更新日期：2012-01-10 00:00:00
abstract：:Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in working memory (WM) can be apparent early in the ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pnpbp.2017.04.002
更新日期：2017-07-03 00:00:00
abstract：:1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS star...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(83)90093-3
更新日期：1983-01-01 00:00:00
abstract：:Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2015.04.009
更新日期：2015-12-03 00:00:00
abstract：:Treatment of the positive psychotic symptoms of schizophrenia with standard antipsychotic drugs (APDs) is ineffective in a proportion of cases. For these treatment resistant patients the alternative is the APD clozapine which is superior to other agents but carries serious side effects. Why clozapine is uniquely effec...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2012.10.025
更新日期：2013-01-10 00:00:00
abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.08.010
更新日期：2019-03-08 00:00:00
abstract：:1-methyl-4-phenylpyridinium (MPP+) is a drug that induces a Parkinson's-like syndrome in several species. Oxidative stress resulting from either excess generation or reduced scavenging of free radicals has been proposed to play a role in its neurotoxicity. It has been suggested that metallothionein (MT) protects again...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(99)00077-9
更新日期：2000-01-01 00:00:00
