当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats.

The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats.

Abstract：

:The influence of 20 min global cerebral ischemia on the free arachidonic acid (FAA) level and Na+,K+-ATPase activity in the rat hippocampus at different time points after ischemia was examined. In addition, the effect of MK-801 on mentioned parameters was studied. Animals were exposed to 20 min global cerebral ischemia and were sacrificed immediately, 0.5, 1, 2, 6, 24, 48, 72, and 168 h after ischemic procedure. The level of the FAA and the Na+,K+-ATPase activity was measured during all reperfusion periods examined. Various doses of MK-801 (0.3, 1.0, 3.0, and 5.0 mg/kg) had been injected 30 min before ischemic procedure started. It was found that 20 min global cerebral ischemia induces a statistically significant increase of the FAA level immediately after ischemia and during the first 0.5 h of reperfusion. After a transient decrease, the level of FAA level increased again after 24 and 168 h of recirculation. Treatment with 3.0 mg/kg of MK-801 significantly prevented the FAA accumulation immediately and 0.5 h after ischemic insult while application of 5.0 mg/kg of MK-801 exerted a protective effect during the first 24 h. Global cerebral ischemia induces the significant decline in the Na+,K+-ATPase activity in the hippocampus starting from 1 to 168 h of reperfusion. Maximal inhibition was obtained 24 h after the ischemic damage. Application of 3.0 mg/kg of MK-801 exerted statistically significant protection during the first 24 h while the treatment with 5.0 mg/kg of MK-801 prevented fall in enzymatic activity during all reperfusion periods examined. Our results suggest that, in spite of different and complex pathophysiological mechanisms involved in the increase of FAA level and the decrease of the Na+,K+-ATPase activity, blockade of NMDA receptor subtype provides a very important strategy for the treatment of the postischemic excitotoxicity.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Mrsić-Pelcić J,Zupan G,Maysinger D,Pelcić G,Vitezić D,Simonić A

doi

10.1016/s0278-5846(02)00296-8

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1319-26

issue

7-8

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(02)00296-8

journal_volume

26

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Staging and profiling for schizophrenia spectrum disorders: Inter-rater reliability after a short training course.

    abstract：OBJECTIVE:Clinical staging and profiling have been proposed as a new approach in order to refine the diagnostic assessment of schizophrenia spectrum disorders. However, only limited evidence is available for the inter-rater reliability of the clinical staging and profiling model. The aim of the present study was theref...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109856

    authors： Berendsen S,van der Paardt JW,Van HL,van Bruggen M,Nusselder H,Jalink M,de Peuter OR,Peen J,van Tricht MJ,de Haan L

    更新日期：2020-04-20 00:00:00

  • Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients.

    abstract：:Several lines of evidence suggest that the human 5-HT(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. A pharmocogenetics study of this receptor may therefore be useful in developing individualized therapy. But few studies about it have been done. In t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2009.02.008

    authors： Wei Z,Wang L,Xuan J,Che R,Du J,Qin S,Xing Y,Gu B,Yang L,Li H,Li J,Feng G,He L,Xing Q

    更新日期：2009-04-30 00:00:00

  • LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig.

    abstract：:1. We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behav...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90017-1

    authors： Carvey P,Nausieda P,Weertz R,Klawans H

    更新日期：1989-01-01 00:00:00

  • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA.

    abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.002

    authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

    更新日期：2004-03-01 00:00:00

  • Gamma-aminobutyric acid and mefloquine-induced seizures in mice.

    abstract：:The role of GABAergic mechanism in the convulsant effect of mefloquine was investigated in mice. Mefloquine dose dependently induced tonic seizures in mice. Aminooxyacetic acid, diaminobutyric acid and muscimol significantly protected mice against mefloquine-induced seizures by significantly delaying the onset and dec...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.04.030

    authors： Amabeoku GJ,Farmer CC

    更新日期：2005-07-01 00:00:00

  • Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers.

    abstract：:People with Huntington's disease (HD) exhibit altered processing of emotional information, especially disgust and other negative emotions. These impairments are likely due to the effects of the disease on underlying brain networks. We examined whether oxytocin, when given intranasally, would normalise aberrant brain r...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.09.023

    authors： Labuschagne I,Poudel G,Kordsachia C,Wu Q,Thomson H,Georgiou-Karistianis N,Stout JC

    更新日期：2018-02-02 00:00:00

  • Anxiety and beta-adrenergic receptor function in a normal population.

    abstract：:Many studies have shown a close relationship between anxiety and beta-adrenergic receptor function in patients with anxiety disorders. This study examined the relationship between beta-adrenergic receptor function and anxiety levels in a normal population. Subjects for this study included 36 men and 44 women between t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.04.027

    authors： Kang EH,Yu BH

    更新日期：2005-06-01 00:00:00

  • Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temperature, behavior, and blood alcohol concentration.

    abstract：:Mecamylamine, a noncompetitive antagonist of nicotinic acetylcholine receptors, has many potential clinical applications, including treating alcohol dependency. However, little is known about the combined effects of mecamylamine and alcohol on visual system electrophysiology. We examined the separate and combined effe...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.11.016

    authors： Hetzler BE,Bauer AM

    更新日期：2013-06-03 00:00:00

  • Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats.

    abstract：:Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major depression. Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in roden...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.01.004

    authors： Garcia LS,Comim CM,Valvassori SS,Réus GZ,Stertz L,Kapczinski F,Gavioli EC,Quevedo J

    更新日期：2009-04-30 00:00:00

  • Classic hallucinogens in the treatment of addictions.

    abstract：:Addictive disorders are very common and have devastating individual and social consequences. Currently available treatment is moderately effective at best. After many years of neglect, there is renewed interest in potential clinical uses for classic hallucinogens in the treatment of addictions and other behavioral hea...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.03.002

    authors： Bogenschutz MP,Johnson MW

    更新日期：2016-01-04 00:00:00

  • Exploring the relationship between fairness and 'brain types' in children with high-functioning autism spectrum disorder.

    abstract：BACKGROUND:Existing research typically focuses on only one domain of cognition with regard to fairness-theory of mind or executive function. However, children with High-functioning autism spectrum disorder (HF-ASD) are cognitively impaired in both domains. Moreover, little is known about fairness characteristics in chi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.07.008

    authors： Wang Y,Xiao Y,Li Y,Chu K,Feng M,Li C,Qiu N,Weng J,Ke X

    更新日期：2019-01-10 00:00:00

  • Subtypes of negative symptoms: the primary subtype in schizophrenic and non-schizophrenic patients.

    abstract：:1. The specificity of negative symptoms remains an open question and requires further research. 2. Subtyping negative symptoms has been showed to be a very relevant point for the identification of primary negative symptoms and for their pharmacotherapy. Negative symptoms as a whole have been demonstrated in schizophre...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(94)90062-0

    authors： Gerbaldo H,Helisch A,Schneider B,Philipp M,Benkert O

    更新日期：1994-03-01 00:00:00

  • Behavioral modifications in relation to hypothyroidism and hyperthyroidism in adult rats.

    abstract：:1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90044-4

    authors： Fundaro A

    更新日期：1989-01-01 00:00:00

  • Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study.

    abstract：:Altered cerebral energy metabolism and mitochondrial dysfunction in periphery and in brain are implicated in the pathophysiology of schizophrenia. This study investigated whether cerebral glucose metabolism (rCGM) abnormalities are linked to altered mitochondrial complex I activity in the periphery, in schizophrenia. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.12.025

    authors： Ben-Shachar D,Bonne O,Chisin R,Klein E,Lester H,Aharon-Peretz J,Yona I,Freedman N

    更新日期：2007-05-09 00:00:00

  • Dependence potential of antidepressants compared to benzodiazepines.

    abstract：:The aim of the present study was to compare the possible dependence potential of antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in Neuropsychiatry (SCAN), the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ) and the Symptom Checklist-90 (SCL-90) were administered...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00209-9

    authors： van Broekhoven F,Kan CC,Zitman FG

    更新日期：2002-06-01 00:00:00

  • Event-related brain potentials in depressed patients treated with electroconvulsive therapy.

    abstract：:1. As impairment of attention has long been recognized as a clinical feature of depression, we undertook to evaluate in depressed subjects and controls a feature of the event-related brain potentials (ERP) the N100 wave which has been linked to attentional processes. 2. This study involved collection of EEG data in an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90056-0

    authors： Coffman JA,Torello MW,Lewis CE,Fortin LD,Martin DJ

    更新日期：1989-01-01 00:00:00

  • Interferon: a candidate as the endogenous substance preventing tolerance and dependence to brain opioids.

    abstract：:It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Dafny N

    更新日期：1984-01-01 00:00:00

  • Psychoneuroendocrine assessment of posttraumatic stress disorder: current progress and new directions.

    abstract：:1. Studies in our laboratory have used the psychoendocrine strategy to explore differences in basal hormone levels between patients with posttraumatic stress disorder (PTSD) and other groups. This approach has allowed us to explore the relationship between hormone levels and specific psychological and biological proce...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(93)90004-c

    authors： Yehuda R,Giller EL Jr,Mason JW

    更新日期：1993-07-01 00:00:00

  • Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients.

    abstract：INTRODUCTION:High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in sc...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2013.10.019

    authors： Prikryl R,Ustohal L,Kucerova HP,Kasparek T,Jarkovsky J,Hublova V,Vrzalova M,Ceskova E

    更新日期：2014-03-03 00:00:00

  • Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: possible role in apoptosis.

    abstract：:1. The carboxyl terminus of the amyloid precursor protein (APP) has several identified regions that may potentially contribute to the pathogenic effects of Alzheimer's disease (AD). To examine these effects, the authors iodinated a short synthetic peptide corresponding to amino acids 679-687 of APP695. They also produ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00046-9

    authors： Daly J,Lahiri DK,Kotwal GJ

    更新日期：1999-07-01 00:00:00

  • Anomalous intrinsic connectivity within and between visual and auditory networks in major depressive disorder.

    abstract：OBJECTIVE:Major depressive disorder (MDD) is a ubiquitous mental illness with heterogeneous symptoms, however, the pathophysiology mechanisms are still not fully understood. Clinical and preclinical studies suggested that depression could cause disturbances in sensory perception systems, disruptions in auditory and vis...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.109889

    authors： Lu F,Cui Q,Huang X,Li L,Duan X,Chen H,Pang Y,He Z,Sheng W,Han S,Chen Y,Yang Y,Luo W,Yu Y,Jia X,Tang Q,Li D,Xie A,Chen H

    更新日期：2020-06-08 00:00:00

  • Alcoholic organic brain disease: nosology and pathophysiologic mechanisms.

    abstract：:Study of alcoholic chronic organic brain syndrome may have applicability to the large population of alcoholics with less severe cerebral dysfunction. Brain impairment in alcoholics may be conceptualized as two clinically and neuropathologically distinguishable organic brain syndromes: alcohol amnestic disorder or Kors...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(86)90069-2

    authors： Martin PR,Adinoff B,Weingartner H,Mukherjee AB,Eckardt MJ

    更新日期：1986-01-01 00:00:00

  • Cumulative mean change procedure: application to a comparative trial of venlafaxine, imipramine, and placebo in the treatment of major depression.

    abstract：:1. A simple summary measure--namely, cumulative mean change (CMC)--is proposed for analyzing incomplete repeated measures in clinical settings. 2. A simple test statistic that uses the correlation between subject responses was derived and applied to a study comparing an investigational antidepressant, venlafaxine, wit...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(94)90077-9

    authors： Entsuah AR,Bradley MM,Littman GS

    更新日期：1994-07-01 00:00:00

  • Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation.

    abstract：INTRODUCTION:Bipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. OBJECTIVES:The purpose of this review is to critically review evidence su...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2014.06.005

    authors： Sharma AN,Bauer IE,Sanches M,Galvez JF,Zunta-Soares GB,Quevedo J,Kapczinski F,Soares JC

    更新日期：2014-10-03 00:00:00

  • Effects of apomorphine and clozapine on conditioned freezing and latent inhibition.

    abstract：:Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus as unconditioned stimulus (US). Much evidence has also been provided for the involvement of dopamine in the setting up of adaptive responses to aversive states generated at this mesencephali...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00153-2

    authors： Masson S,Avanzi V,Troncoso AC,Brandão ML

    更新日期：2003-09-01 00:00:00

  • A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.

    abstract：:Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic var...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.08.010

    authors： Masui T,Hashimoto R,Kusumi I,Suzuki K,Tanaka T,Nakagawa S,Suzuki T,Iwata N,Ozaki N,Kato T,Takeda M,Kunugi H,Koyama T

    更新日期：2008-01-01 00:00:00

  • Effects of topiramate in patients with cerebellar tremor.

    abstract：PURPOSE:To evaluate the safety and potential beneficial effect of topiramate (TPM) as monotherapy or adjunctive therapy to carbamazepine (CBZ) in patients with cerebellar tremor. METHODS:Nine patients with cerebellar tremor participated a 4-week, open-label, prospective-controlled trial. TPM was given as monotherapy (...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0278-5846(03)00170-2

    authors： Sechi G,Agnetti V,Sulas FM,Sau G,Corda D,Pitzolu MG,Rosati G

    更新日期：2003-09-01 00:00:00

  • Stimulatory effect of butoctamide hydrogen succinate on REM sleep in normal humans.

    abstract：:1. The efficacy of butoctamide hydrogen succinate (BAHS) was compared with that of nitrazepam on the basis of the polysomnograms and the subjective assessments. 2. Twelve healthy male students were divided into three groups consisting of 4 subjects each with were administered BAHS 600 mg, nitrazepam 5 mg, and BAHS 600...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(95)00020-v

    authors： Mizuki Y,Suetsugi M,Hotta H,Ushijima I,Yamada M

    更新日期：1995-05-01 00:00:00

  • White matter structural alterations in pediatric obsessive-compulsive disorder: relation to symptom dimensions.

    abstract：UNLABELLED:The aims of this study were to identify gray matter (GM) and white matter (WM) volume abnormalities in pediatric obsessive-compulsive patients, to examine their relationship between these abnormalities and the severity of disorder, and to explore whether they could be explained by the different symptom dimen...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2014.06.009

    authors： Lázaro L,Ortiz AG,Calvo A,Ortiz AE,Moreno E,Morer A,Calvo R,Bargallo N

    更新日期：2014-10-03 00:00:00

  • Animal models: trait or state measure? The test-retest reliability of the elevated plus-maze and behavioral despair.

    abstract：:1. The use of animal models in certain types of psychobiological studies (for instance, the relationship between anxiety and depression) requires that the behavior measured is stable over time. 2. The test-retest reliability of the elevated plus-maze indexes of anxiety and the immobility time in the behavioral despair...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(00)00092-0

    authors： Andreatini R,Bacellar LF

    更新日期：2000-05-01 00:00:00