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The role of neurotrophins in bipolar disorder.

Abstract：

:Bipolar disorder (BD) is a chronic psychiatric illness of which the pathophysiology remains partially unknown. Abnormalities of neurotrophins and other trophic factors orchestrate important alterations which could be implicated in the etiology of BD. Therefore, the main objective of this review is to examine the recent findings and critically evaluate the potential role of neurotrophins that may allow us to substantially improve the development of novel treatments. The most recently published findings highlight that brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF-1) and vascular endothelial growth factor (VEGF) present distinct patterns in the different stages of BD, suggesting their potential in the identification of the BD subgroups and may ultimately advance treatment strategies.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Scola G,Andreazza AC

doi

10.1016/j.pnpbp.2014.08.013

subject

Has Abstract

pub_date

2015-01-02 00:00:00

pages

122-8

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(14)00163-8

journal_volume

56

pub_type

杂志文章,评审

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