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Predictors of treatment response in patients with posttraumatic stress disorder.

Abstract：

:1. This study examines the relation between baseline clinical characteristics in patients with posttraumatic stress disorder (PTSD) and response to treatment with a reversible monoamine oxidase A inhibitor (RIMA), brofaromine. 2. Data from two comparable, double-blind, placebo-controlled studies of brofaromine in patients with PTSD were combined. Bivariate analyses of variables of interest and outcome were performed. 3. Treatment response was significantly associated with lower baseline scores on the full scale Clinician-Administered PTSD Scale (CAPS) and on CAPS subscales B (re-experiencing) and C (avoidance/numbing), as well as to drug treatment with brofaromine. Placebo response was related to a history of past sexual trauma. 4. Brofaromine may have therapeutic benefit in treating PTSD, with lower baseline levels of reexperiencing and avoidance/numbing and overall less severe PTSD most predictive of outcome.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Connor KM,Hidalgo RB,Crockett B,Malik M,Katz RJ,Davidson JR

doi

10.1016/s0278-5846(00)00163-9

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

337-45

issue

2

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(00)00163-9

journal_volume

25

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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