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Autoradiography reveals selective changes in serotonin binding in neocortex of patients with temporal lobe epilepsy.

Abstract：

:The main goal of the present study was to evaluate binding to serotonin in the neocortex surrounding the epileptic focus of patients with mesial temporal lobe epilepsy (MTLE). Binding to 5-HT, 5-HT(1A), 5-HT(4), 5-HT(7) receptors and serotonin transporter (5-HTT) in T1-T2 gyri of 15 patients with MTLE and their correlations with clinical data, neuronal count and volume were determined. Autopsy material acquired from subjects without epilepsy (n=6) was used as control. The neocortex from MTLE patients demonstrated decreased cell count in layers III-IV (21%). No significant changes were detected on the neuronal volume. Autoradiography experiments showed the following results: reduced 5-HT and 5-HT(1A) binding in layers I-II (24% and 92%, respectively); enhanced 5-HT(4) binding in layers V-VI (32%); no significant changes in 5-HT(7) binding; reduced 5-HTT binding in all layers (I-II, 90.3%; III-IV, 90.3%, V-VI, 86.9%). Significant correlations were found between binding to 5-HT(4) and 5-HT(7) receptors and age of seizure onset, duration of epilepsy and duration of antiepileptic treatment. The present results support an impaired serotoninergic transmission in the neocortex surrounding the epileptic focus of patients with MTLE, a situation that could be involved in the initiation and propagation of seizure activity.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Rocha L,Lorigados-Pedre L,Orozco-Suárez S,Morales-Chacón L,Alonso-Vanegas M,García-Maeso I,Villeda-Hernández J,Osorio-Rico L,Estupiñán B,Quintana C

doi

10.1016/j.pnpbp.2007.04.014

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

1208-18

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(07)00146-7

journal_volume

31

pub_type

杂志文章

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