Abstract:
:Accumulating evidence supports the hypothesis that modulation of glutamatergic system via NMDA receptors and mGlu5 receptors might be an effective antidepressant therapy. However, clinical application of NMDA and mGlu5 antagonists in the therapy of depression is still an open question. In the present study we investigated potential antidepressant-like effect of a functional NMDA and mGlu5 receptor antagonist, acamprosate, which has been used in the therapy of human alcoholics as an anti-craving drug for more than 20 years and is considered as a safe substance. We have found potential antidepressant-like effect of acamprosate at doses of 100-400 mg/kg in the TST in C57BL/6J mice. Furthermore we have shown that the antidepressant-like effect of acamprosate used at a dose of 200 mg/kg was dependent on NMDA and mGlu5 receptor blockade, since NMDA (25 mg/kg) and mGlu5 receptor positive allosteric modulator, CDPPB (3 mg/kg), antagonized its activity in the TST. These data suggest that acamprosate may induce antidepressant-like effect and that NMDA and mGlu5 receptors are crucial targets of acamprosate in this action.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Pałucha-Poniewiera A,Pilc Adoi
10.1016/j.pnpbp.2012.05.015subject
Has Abstractpub_date
2012-10-01 00:00:00pages
102-6issue
1eissn
0278-5846issn
1878-4216pii
S0278-5846(12)00117-0journal_volume
39pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Progress in neuro-psychopharmacology & biological psychiatry
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doi:10.1016/j.pnpbp.2004.08.005
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journal_title:Progress in neuro-psychopharmacology & biological psychiatry
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更新日期:2018-01-03 00:00:00