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Changes in thyroid hormone levels associated with desipramine response in adolescent depression.

Abstract：

:1. The authors recently reported that acutely ill depressed adolescents have elevated plasma T4 and fT4 compared to controls. Studies in adult depression suggest antidepressant response is associated with decreases in these elevated levels. The effect of antidepressant treatment on adolescent thyroid indices has not been examined. 2. Thyroid indices were examined in 12 adolescent patients (4 male, 8 female; age 14-19y) in the active treatment arm of a double-blind, placebo-controlled desipramine trial (200 mg/day for 6 weeks). Antidepressant responders had higher pre-treatment levels of T4 and larger decreases were observed responders vs. nonresponders. 3. These results replicate findings observed in adult depressed patients and suggest similar alterations in the hypothalamic-pituitary-thyroid (HPT) axis function in adolescent depression.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Sokolov ST,Kutcher SP,Joffe RT

doi

10.1016/0278-5846(96)00083-8

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

1053-63

issue

6

eissn

0278-5846

issn

1878-4216

pii

0278-5846(96)00083-8

journal_volume

20

pub_type

临床试验,杂志文章,随机对照试验

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