Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder.

Abstract:

:While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, including 47 patients with schizophrenia, 47 with bipolar disorder, and 115 healthy controls, was obtained via OpenNeuro. Whole-brain tractography was performed using Unscented Kalman filter-based two-tensor tractography and White Matter Query Language. Diffusion indices, including fractional anisotropy (FA), axial diffusivity, radial diffusivity (RD), and trace (TR), were used to compare subject groups. Spearman's partial correlation with a covariate of age was used for correlation with clinical variables. Both patient groups exhibited significantly higher RD in the left external capsule and TR in the right extreme capsule. Significantly lower FA in the left external capsule, right thalamo-occipital and thalamo-parietal tracts were found in the schizophrenia group in comparison with bipolar disorder and healthy control groups. Compared with healthy controls, patients with schizophrenia had significantly lower FA in the left-to-right lateral orbitofrontal commissural tract. There were possible associations of the FA and RD of the left external capsule with the anxiety-depression score of the Brief Psychiatric Rating Scale in patients with schizophrenia. The white matter alterations identified in schizophrenia and bipolar disorder may be a neurobiological basis contributing to characterization of the two disorders.

authors

Joo SW,Kim H,Jo YT,Yoon W,Kim Y,Lee J

doi

10.1016/j.pnpbp.2020.110175

subject

Has Abstract

pub_date

2020-11-12 00:00:00

pages

110175

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(20)30491-7

pub_type

杂志文章
  • Effect of dietary phenylalanine on the plasma concentrations of phenylalanine, phenylethylamine and phenylacetic acid in healthy volunteers.

    abstract::1. Phenylethylamine has been proposed as a neuromodulator in several psychiatric and other brain disorders, and its concentration and that of its major metabolite, phenylacetic acid, in plasma may prove useful as state or trait markers in diagnosis, treatment or in the elucidation of biochemical mechanisms of these di...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90051-2

    authors: Davis BA,O'Reilly RL,Placatka CL,Paterson IA,Yu PH,Durden DA

    更新日期:1991-01-01 00:00:00

  • Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling.

    abstract::Electroacupuncture (EA) is a clinically useful physiological therapy that has been recently adopted to treat several brain disorders. However, the potential role of early EA intervention in the prevention of posttraumatic stress disorder (PTSD) as well as its potential cellular and molecular mechanism has never been i...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2019.03.018

    authors: Xue F,Xue SS,Liu L,Sang HF,Ma QR,Tan QR,Wang HN,Zhou CH,Peng ZW

    更新日期:2019-07-13 00:00:00

  • Investigation of the impact of preconditioning with lipopolysaccharide on inflammation-induced gene expression in the brain and depression-like behavior in male mice.

    abstract::Although several recent studies have suggested that neuroinflammation plays a role in depression, both medication and neuroinflammatory preventive strategies have been poorly investigated. Recent studies have indicated that preconditioning with lipopolysaccharide (LPS) reduces the damage that occurs following ischemic...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.109978

    authors: Koga M,Toda H,Kinoshita M,Asai F,Nagamine M,Shimizu K,Kobayashi Y,Morimoto Y,Yoshino A

    更新日期:2020-12-20 00:00:00

  • The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus.

    abstract::Epilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathophysiological mechani...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2014.02.001

    authors: Matos G,Scorza FA,Mazzotti DR,Guindalini C,Cavalheiro EA,Tufik S,Andersen ML

    更新日期:2014-06-03 00:00:00

  • Psychoneuroendocrine assessment of posttraumatic stress disorder: current progress and new directions.

    abstract::1. Studies in our laboratory have used the psychoendocrine strategy to explore differences in basal hormone levels between patients with posttraumatic stress disorder (PTSD) and other groups. This approach has allowed us to explore the relationship between hormone levels and specific psychological and biological proce...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0278-5846(93)90004-c

    authors: Yehuda R,Giller EL Jr,Mason JW

    更新日期:1993-07-01 00:00:00

  • Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine.

    abstract::Organic cation transporter 2 (OCT2) and 3 (OCT3) are low-affinity, high-capacity transporters (uptake-2) expressed in the central nervous system (CNS) and other major organs. Proven to be essential components in the CNS functions, OCT2 and OCT3 are suggested as potential targets of antidepressant therapeutics recently...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2013.11.005

    authors: Sun S,Wang K,Lei H,Li L,Tu M,Zeng S,Zhou H,Jiang H

    更新日期:2014-03-03 00:00:00

  • Effects of chronic nicotine on the temporal structure of anxiety-related behavior in rats tested in hole-board.

    abstract::The present study aimed to assess the behavioral effects of chronic treatments of different doses of nicotine by using both quantitative and multivariate T-pattern analysis (TPA), which can reveal hidden behavioral structures, in Sprague-Dawley rats tested in the hole-board apparatus. To this purpose, nicotine ditartr...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2019.109731

    authors: Casarrubea M,Pierucci M,Aiello S,Cassar D,Deidda G,Crescimanno G,Di Giovanni G

    更新日期:2020-01-10 00:00:00

  • The decreased availability of L-tryptophan in depressed females: clinical and biological correlates.

    abstract::1. The plasma levels of L-tryptophan (L-TRP) and the sum of five competing amino acids (CAA) namely tyrosine, phenylalanine, valine, leucine, isoleucine, were determined in 79 depressed females categorized according to the DSM-III. 2. In these patients the authors measured several parameters known to affect the availa...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(90)90076-s

    authors: Maes M,Vandewoude M,Schotte C,Martin M,D'Hondt P,Scharpe S,Blockx P

    更新日期:1990-01-01 00:00:00

  • VEGF serum levels in depressed patients during SSRI antidepressant treatment.

    abstract::Recent evidence indicates that the vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both the depression aetiology and the response to pharmacological and non pharmacological antidepressant treatments. To investigate whether VEGF peripheral levels are altered in depression...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2008.11.009

    authors: Ventriglia M,Zanardini R,Pedrini L,Placentino A,Nielsen MG,Gennarelli M,Bocchio-Chiavetto L

    更新日期:2009-02-01 00:00:00

  • Interferon: a candidate as the endogenous substance preventing tolerance and dependence to brain opioids.

    abstract::It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Dafny N

    更新日期:1984-01-01 00:00:00

  • Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease.

    abstract::Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive impairment (MCI), which refers to a t...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.01.011

    authors: Egerházi A,Berecz R,Bartók E,Degrell I

    更新日期:2007-04-13 00:00:00

  • Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction.

    abstract::Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2017.06.015

    authors: Watt MJ,Weber MA,Davies SR,Forster GL

    更新日期:2017-10-03 00:00:00

  • A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late-life moderated by the environment.

    abstract:OBJECTIVE:This study aimed to clarify the relationship between the APOE alleles and depressive symptoms of older adults, considering individual characteristics and the effect of neighborhood environment. METHODS:Using a multilevel, stratified sampling strategy, 500 elders were recruited from official household records...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.09.023

    authors: Yen YC,Rebok GW,Yang MJ,Lung FW

    更新日期:2008-02-15 00:00:00

  • Oscillatory potentials abnormalities in regular cannabis users: Amacrine cells dysfunction as a marker of central dopaminergic modulation.

    abstract:BACKGROUND:Cannabis is a neuromodulating substance that acts on central synaptic transmission. Regular cannabis use induces a decreased capacity for dopamine synthesis in the brain. The retina is considered an easy means of investigating dysfunctions of synaptic transmission in the brain. We have previously studied the...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110083

    authors: Polli L,Schwan R,Albuisson E,Malbos L,Angioi-Duprez K,Laprevote V,Schwitzer T

    更新日期:2020-08-27 00:00:00

  • Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging.

    abstract::Memory decline in human aging and dementia is linked to dysfunction of the cholinergic system. Aging dogs demonstrate cognitive impairments and neuropathology that models human aging and dementia. This paper reviews recent evidence suggesting cholinergic involvement in canine cognitive aging based on studies with the ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2004.12.008

    authors: Araujo JA,Studzinski CM,Milgram NW

    更新日期:2005-03-01 00:00:00

  • Adjunctive quetiapine in bipolar patients partially responsive to lithium or valproate.

    abstract::Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0278-5846(03)00145-3

    authors: Sokolski KN,Denson TF

    更新日期:2003-08-01 00:00:00

  • Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.

    abstract::The present study investigated the role of mitogen-activated protein kinase (MAPK) in orofacial neuropathic pain following chronic constriction injury of the infraorbital nerve (ION-CCI). Experiments were carried out on male Sprague-Dawley rats weighing between 200 and 230 g. The ION was separated from adhering tissue...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.05.016

    authors: Lim EJ,Jeon HJ,Yang GY,Lee MK,Ju JS,Han SR,Ahn DK

    更新日期:2007-08-15 00:00:00

  • Increased inositol-monophosphatase activity by lithium treatment in bipolar patients.

    abstract::Inhibition of inositol monophosphatase (IMPase) enzyme is the target mechanism of action of lithium. However, increased activity of mRNA levels by lithium has been reported. These two diverse effects were shown after relatively short periods of lithium administration. The aim of this study was to observe the effect of...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2004.01.020

    authors: Kaya N,Resmi H,Ozerdem A,Guner G,Tunca Z

    更新日期:2004-05-01 00:00:00

  • Delusional infestation: neural correlates and antipsychotic therapy investigated by multimodal neuroimaging.

    abstract:INTRODUCTION:In delusional infestation (DI), as with other non-schizophrenic psychotic disorders, little is known about the neural basis and the mechanisms of antipsychotic treatment. We aimed at investigating the brain circuitry involved in DI and the role of postsynaptic D2 receptors in mediating the effects of antip...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.06.022

    authors: Freudenmann RW,Kölle M,Huwe A,Luster M,Reske SN,Huber M,Lepping P,Wolf RC,Schönfeldt-Lecuona C

    更新日期:2010-10-01 00:00:00

  • Propranolol in schizophrenia.

    abstract::1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS star...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(83)90093-3

    authors: Sethi BB,Dubé S

    更新日期:1983-01-01 00:00:00

  • Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD.

    abstract::Posttraumatic stress disorder (PTSD) is a debilitating condition highly comorbid with depression. The endocannabinoid (eCB) system and brain-derived neurotrophic factor (BDNF) are suggestively involved in both disorders. We examined whether cannabinoids can prevent the long-term depressive-like symptoms induced by exp...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2018.01.026

    authors: Burstein O,Shoshan N,Doron R,Akirav I

    更新日期:2018-06-08 00:00:00

  • Mitochondrial impairments contribute to spatial learning and memory dysfunction induced by chronic tramadol administration in rat: Protective effect of physical exercise.

    abstract::Despite the worldwide use of tramadol, few studies have been conducted about its effects on memory and mitochondrial function, and controversial results have been reported. Recently, there has been an increasing interest in physical exercise as a protective approach to neuronal and cognitive impairments. Therefore, th...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2017.07.022

    authors: Mehdizadeh H,Pourahmad J,Taghizadeh G,Vousooghi N,Yoonessi A,Naserzadeh P,Behzadfar L,Rouini MR,Sharifzadeh M

    更新日期:2017-10-03 00:00:00

  • The effect of sulpiride on amphetamine-induced disruption of overshadowing in the rat.

    abstract::Previous studies have demonstrated dopaminergic (DA) modulation of stimulus selection performance in the overshadowing and Kamin blocking (KB) tasks. Systemic administration of the DA agonist D-amphetamine selectively disrupted overshadowing in the rat. In the present study, we examined the ability of the selective DA...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2004.06.009

    authors: O'Tuathaigh CP,Moran PM

    更新日期:2004-12-01 00:00:00

  • Function of the hippocampus in memory formation: desperately seeking resolution.

    abstract::Despite considerable efforts and successes investigating the function of the hippocampal formation in memory processes, there are still numerous elusive key issues. Some of them will be addressed in this review. We will argue that recent evidence supports hippocampal participation in several memory processes, such as ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/s0278-5846(01)00153-1

    authors: Riedel G,Micheau J

    更新日期:2001-05-01 00:00:00

  • A meta-analysis of chemokines in major depression.

    abstract::Chemokines are increasingly recognised as playing a role in depression. Here we meta-analyse the data on concentrations of all chemokines in patients diagnosed with a major depression versus healthy controls. We included studies which utilised Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for major de...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.pnpbp.2016.02.006

    authors: Eyre HA,Air T,Pradhan A,Johnston J,Lavretsky H,Stuart MJ,Baune BT

    更新日期:2016-07-04 00:00:00

  • The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders.

    abstract::1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxyphenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined. The same relationships apply fo...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90025-v

    authors: Davis BA,Durden DA,O'Reilly RL

    更新日期:1991-01-01 00:00:00

  • The effect of monoamine oxidase inhibitors compared with classical tricyclic antidepressants on learned helplessness paradigm.

    abstract::The present study investigated the effect of monoamine oxidase inhibitors, nialamide which is a non specific monoamine oxidase inhibitor (MAOI), toloxatone which is a A type MAOI and L-deprenyl which is a B type MAOI compared with classical tricyclic antidepressants (clomipramine, desipramine and imipramine), on the e...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(87)90026-1

    authors: Martin P,Soubrie P,Simon P

    更新日期:1987-01-01 00:00:00

  • Biological markers in alcoholism.

    abstract::The search for biological markers of a predisposition towards alcoholism is the result of data indicating that this disorder is genetically influenced. The present paper reviews some methodological considerations important for trait marker research in alcoholism. To date, the most promising results have come from stud...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(86)90073-4

    authors: Schuckit MA

    更新日期:1986-01-01 00:00:00

  • Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population.

    abstract:OBJECTIVE:Genetic factors play a critical role in the etiology of bipolar disorder (BPAD). Previous studies suggested an association between thyroid dysfunction and BPAD. We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated w...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.05.003

    authors: He B,Li J,Wang G,Ju W,Lu Y,Shi Y,He L,Zhong N

    更新日期:2009-08-31 00:00:00

  • Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status.

    abstract::Dietary antioxidants might exert an important role in the aging process by relieving oxidative damage, a likely cause of age-associated brain dysfunctions. This study aims to investigate the influence of esculetin (6,7-dihydroxycoumarin), a naturally occurring antioxidant in the diet, on mood-related behaviors and cog...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.08.007

    authors: Martín-Aragón S,Villar Á,Benedí J

    更新日期:2016-02-04 00:00:00