Mental health outcomes following naltrexone implant treatment for heroin-dependence.

Abstract:

BACKGROUND:Oral naltrexone is an approved treatment for opioid dependence. However, the impact of sustained release naltrexone on the mental health of treated opioid users has not been studied. AIMS:To assess if naltrexone via implant treatment was associated with any change in (i) risk, (ii) rate, and (iii) duration for hospital morbidity related to several categories of mental disorders among treated heroin users. METHOD:A cohort of 359 heroin users treated with sustained release naltrexone via implants in Western Australia was retrospectively followed up for mental health related outcomes via a health record linkage system over an average period of 1.78 years post-treatment. RESULTS:Individual patient's risk for hospital mental diagnoses was not altered after naltrexone implant. On a population cohort level, hospital admission rates related to all mental health problems, except mood disorders, declined significantly post-treatment; however, length of hospital stay did not improve. Overall, young, female patients or those with pre-existing mental illness were more likely than other patients to require hospital care for mental health issues following treatment. Longer period of heroin use was associated with poorer mood outcomes. CONCLUSIONS:Naltrexone implants were not associated with an increased risk for hospitalisation due to mental illness, and in most cases, were associated with a decrease in mental related hospital admission rate.

authors

Ngo HT,Tait RJ,Arnold-Reed DE,Hulse GK

doi

10.1016/j.pnpbp.2006.12.005

subject

Has Abstract

pub_date

2007-04-13 00:00:00

pages

605-12

issue

3

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(06)00440-4

journal_volume

31

pub_type

临床试验,杂志文章
  • Schizophrenia and single-carbon metabolism.

    abstract::Schizophrenic patients generally appear to have a disturbed single-carbon metabolism. Methionine and homocysteine are intermediary metabolites in this metabolic system. In a case-control study of the cerebrospinal fluid, a majority of the patients had elevated methionine and a smaller subgroup had elevated homocystein...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2005.06.023

    authors: Regland B

    更新日期:2005-09-01 00:00:00

  • Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone.

    abstract::1. The authors studied the correlations between plasma concentrations of trazodone and mCPP at steady state and those after an initial dose of trazodone. 2. Fifteen depressed patients received trazodone 150 mg at bedtime for 3 weeks, and blood samplings were taken 12 h after the initial dose and 12 h after the last do...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(96)00140-6

    authors: Otani K,Mihara K,Yasui N,Ishida M,Kondo T,Tokinaga N,Ohkubo T,Osanai T,Sugawara K,Kaneko S

    更新日期:1997-01-01 00:00:00

  • Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.

    abstract::A number of neuroprotective effects of curcumin have been demonstrated in recent years. However, whether curcumin exerts any beneficial effects on age-related impaired cognition and memory has not been well characterized; nor was there any detailed data on the molecular pathways activated by curcumin. The present stud...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2013.05.001

    authors: Yu SY,Zhang M,Luo J,Zhang L,Shao Y,Li G

    更新日期:2013-08-01 00:00:00

  • LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig.

    abstract::1. We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behav...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(89)90017-1

    authors: Carvey P,Nausieda P,Weertz R,Klawans H

    更新日期:1989-01-01 00:00:00

  • Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression.

    abstract::Only two-thirds of depressive patients respond to antidepressant treatment. Recently, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we examined the effects of various atypical antipsychotic drugs as adjuvan...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.12.003

    authors: Yoshimura R,Ikenouchi-Sugita A,Hori H,Umene-Nakano W,Katsuki A,Hayashi K,Ueda N,Nakamura J

    更新日期:2010-03-17 00:00:00

  • Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population.

    abstract:OBJECTIVE:Genetic factors play a critical role in the etiology of bipolar disorder (BPAD). Previous studies suggested an association between thyroid dysfunction and BPAD. We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated w...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.05.003

    authors: He B,Li J,Wang G,Ju W,Lu Y,Shi Y,He L,Zhong N

    更新日期:2009-08-31 00:00:00

  • Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng.

    abstract::This study was performed to investigate the anxiolytic-like effects of red ginseng (RG, steamed raw ginseng at 98-100 degrees C) and sun ginseng (SG, heat-processed ginseng at higher temperature) in mice using the elevated plus-maze model. Furthermore, the anxiolytic-like effects of RG and SG were compared to a known ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2005.04.016

    authors: Park JH,Cha HY,Seo JJ,Hong JT,Han K,Oh KW

    更新日期:2005-07-01 00:00:00

  • Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Frégoli symptoms.

    abstract::The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component o...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00293-7

    authors: Papageorgiou C,Lykouras L,Ventouras E,Uzunoglu N,Christodoulou GN

    更新日期:2002-05-01 00:00:00

  • Elevated plasma γ-aminobutyrate/glutamate ratio and responses to risperidone antipsychotic treatment in schizophrenia.

    abstract:BACKGROUND:γ-aminobutyrate (GABA) and Glutamate (Glu) are respectively two major inhibitory and excitatory neurotransmitters in the central nervous system and recent theories propose that both of their signaling complexes are compromised in patients with schizophrenia. METHODS:The changes in plasma GABA, Glu and GABA/...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2010.07.006

    authors: Cai HL,Zhu RH,Li HD,Zhang XH,Hu L,Yang W,Ye HS

    更新日期:2010-10-01 00:00:00

  • Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation.

    abstract:INTRODUCTION:Bipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. OBJECTIVES:The purpose of this review is to critically review evidence su...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2014.06.005

    authors: Sharma AN,Bauer IE,Sanches M,Galvez JF,Zunta-Soares GB,Quevedo J,Kapczinski F,Soares JC

    更新日期:2014-10-03 00:00:00

  • The effect of ritanserin on treatment-resistant neuroleptic induced akathisia: case reports.

    abstract::1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(92)90076-q

    authors: Miller CH,Hummer M,Pycha R,Fleischhacker WW

    更新日期:1992-03-01 00:00:00

  • Delusional infestation: neural correlates and antipsychotic therapy investigated by multimodal neuroimaging.

    abstract:INTRODUCTION:In delusional infestation (DI), as with other non-schizophrenic psychotic disorders, little is known about the neural basis and the mechanisms of antipsychotic treatment. We aimed at investigating the brain circuitry involved in DI and the role of postsynaptic D2 receptors in mediating the effects of antip...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.06.022

    authors: Freudenmann RW,Kölle M,Huwe A,Luster M,Reske SN,Huber M,Lepping P,Wolf RC,Schönfeldt-Lecuona C

    更新日期:2010-10-01 00:00:00

  • Effects of MPEP, a selective metabotropic glutamate mGlu5 ligand, on sleep and wakefulness in the rat.

    abstract::Metabotropic glutamate receptors (mGlu) have been implicated in the regulation of physiological and behavioral processes. Pharmacological evidence involves group I mGlu receptors in the regulation of emotional states and antagonism of these receptors has been proposed as a novel class of anxiolytic drugs having also a...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2012.09.011

    authors: Cavas M,Scesa G,Navarro JF

    更新日期:2013-01-10 00:00:00

  • Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats.

    abstract::The purpose of the present study was to investigate the role of central cyclooxygenase (COX) pathways in the modulation of mechanical allodynia following compression of the left trigeminal ganglion. Experiments were carried out on male Sprague-Dawley rats mounted onto a stereotaxic frame under anesthesia. For compress...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.02.010

    authors: Yang GY,Lee MK,Bae YC,Ahn DK

    更新日期:2009-06-15 00:00:00

  • Potentiation of synaptic transmission by (S)-3,5-dihydroxy phenylglycine in the rat dentate gyrus in vitro: a role for voltage dependent calcium channels and protein kinase C.

    abstract::1. The authors have previously shown that direct activation of metabotropic glutamate receptors (mGluRs) by (S)-3,5-dihydroxyphenylglycine ((S)-DHPG) can induce a long-lasting potentiation of synaptic transmission in the rat dentate gyrus in vitro. Here the authors provide further characterisation of this agonist-indu...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(98)00095-5

    authors: O'Leary DM,O'Connor JJ

    更新日期:1999-01-01 00:00:00

  • Right prefrontal function and coping strategies in patients with remitted major depressive disorder.

    abstract:BACKGROUND:Patients with remitted major depressive disorder (rMDD) generally rely on maladaptive coping strategies for stressful situations. These maladaptive copings are associated with an elevated relapse risk of rMDD; however, their neural basis remains poorly understood. METHODS:We enrolled (1) 45 patients with rM...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110085

    authors: Tsujii N,Mikawa W,Adachi T,Sakanaka S,Shirakawa O

    更新日期:2020-09-02 00:00:00

  • Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.

    abstract::Associations between attention deficit hyperactivity disorder (ADHD) and genetic polymorphisms in the dopamine receptors, transporter and metabolizing enzymes have been reported in different ethnic groups. Gene variants may affect disease outcome by acting synergistically or antagonistically and thus their combined ef...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.12.027

    authors: Das M,Das Bhowmik A,Bhaduri N,Sarkar K,Ghosh P,Sinha S,Ray A,Chatterjee A,Mukhopadhyay K

    更新日期:2011-03-30 00:00:00

  • Sex-specific differences in corticosterone secretion, behavioral phenotypes and expression of TrkB.T1 and TrkB.FL receptor isoforms: Impact of systemic TrkB inhibition and combinatory stress exposure in adolescence.

    abstract::Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal da...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2018.05.002

    authors: Azogu I,Liang J,Plamondon H

    更新日期:2018-08-30 00:00:00

  • Pilot study on the use of psychotropic medication in persons with mental retardation.

    abstract:OBJECTIVE:To explore the status of the psychotropic medication in persons with mental retardation 6 years after their deinstitutionalization. METHOD:The authors compared the profiles of psychotropic medication of 60 persons with mental retardation deinstitutionalized (D-sample) from our local mental hospital 6 years a...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2004.05.029

    authors: Radouco-Thomas M,Bolduc M,Brisson A,Brassard P,Fortier L,Thivierge J

    更新日期:2004-08-01 00:00:00

  • Ziprasidone in the treatment of delayed carbon monoxide encephalopathy.

    abstract::Delayed carbon monoxide (CO) encephalopathy is a serious complication of acute CO poisoning. We present a case of successful treatment of ziprasidone, a newer atypical antipsychotic, in delayed CO encephalopathy. A 52-year-old depressed woman suffered acute CO intoxication after an attempt of suicide by burning charco...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2006.01.019

    authors: Hu MC,Shiah IS,Yeh CB,Chen HK,Chen CK

    更新日期:2006-06-01 00:00:00

  • Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms.

    abstract::Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confe...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.pnpbp.2017.07.017

    authors: Chye Y,Solowij N,Ganella EP,Suo C,Yücel M,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Bartholomeusz CF,Lorenzetti V

    更新日期:2017-10-03 00:00:00

  • Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: inverse association with positive symptoms.

    abstract::Excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased superoxide dismutase (SOD) activities, a critical enzyme in the detoxification of superoxide radicals. This study compared plasma SOD activities in 78 never-medicated first-episode an...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.08.018

    authors: Wu Z,Zhang XY,Wang H,Tang W,Xia Y,Zhang F,Liu J,Fu Y,Hu J,Chen Y,Liu L,Chen DC,Xiu MH,Kosten TR,He J

    更新日期:2012-01-10 00:00:00

  • Behavioral modifications in relation to hypothyroidism and hyperthyroidism in adult rats.

    abstract::1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(89)90044-4

    authors: Fundaro A

    更新日期:1989-01-01 00:00:00

  • Changes in heart rate dynamics of patients with schizophrenia treated with risperidone.

    abstract::Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naïve or m...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.04.017

    authors: Chang JS,Yoo CS,Yi SH,Hong KH,Lee YS,Oh HS,Jung DC,Kim YS,Ahn YM

    更新日期:2010-08-16 00:00:00

  • Sputum interleukin-6, tumor necrosis factor-α and Salivary cortisol as new biomarkers of depression in lung cancer patients.

    abstract::Depression is common among lung cancer patients. Increasing evidence has suggested that hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines may play a key role in the pathophysiology of depression as well as cancer. This pilot study investigated the efficacy of sputum interleukin (IL)-6, tumor nec...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2013.08.004

    authors: Du YJ,Zhang HY,Li B,Wu X,Lv YB,Jin HL,Cao YX,Sun J,Luo QL,Gong WY,Liu BJ,Wu JF,Shi SX,Dong JC

    更新日期:2013-12-02 00:00:00

  • Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients.

    abstract::There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible corre...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2006.09.016

    authors: Segal M,Avital A,Berstein S,Derevenski A,Sandbank S,Weizman A

    更新日期:2007-03-30 00:00:00

  • Parkinson's disease: Cogentin with Sinemet, a better response.

    abstract::1. A randomized, placebo controlled, double-blind cross-over study was conducted to evaluate the clinical efficacy of the anticholinergic agent, benztropine mesylate (CogentinR) in 29 patients with mild to moderate, idiopathic Parkinson disease. 2. Patients were maintained on a stable, therapeutically optimal dosage a...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0364-7722(82)80107-0

    authors: Tourtellotte WW,Potvin AR,Syndulko K,Hirsch SB,Gilden ER,Potvin JH,Hansch EC

    更新日期:1982-01-01 00:00:00

  • Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-D-aspartate receptors.

    abstract::Ibogaine (IBO) is an alkaloid with putative antiaddictive properties, alleviating opiates dependence and withdrawal. The glutamate N-methyl-D-aspartate (NMDA) receptors have been implicated in the physiological basis of drug addiction; accordingly, IBO acts as a noncompetitive NMDA antagonist. The purpose of this stud...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0278-5846(03)00109-X

    authors: Leal MB,Michelin K,Souza DO,Elisabetsky E

    更新日期:2003-08-01 00:00:00

  • Effect of aging on the spatial learning deficit produced by diazepam in rats.

    abstract::1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full h...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(96)00065-6

    authors: McNamara RK,Davis TM,Skelton RW

    更新日期:1996-07-01 00:00:00

  • Neurodevelopmental basis of bipolar disorder: a critical appraisal.

    abstract::Neurodevelopmental factors have been implicated in the pathophysiology of mental disorders. However, the evidence regarding their role in bipolar disorder is controversial. We reviewed the pertinent literature searching for evidence regarding a neurodevelopmental origin of bipolar disorder. Findings from clinical, epi...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2008.04.017

    authors: Sanches M,Keshavan MS,Brambilla P,Soares JC

    更新日期:2008-10-01 00:00:00