Abstract：
:1. The authors have previously shown that direct activation of metabotropic glutamate receptors (mGluRs) by (S)-3,5-dihydroxyphenylglycine ((S)-DHPG) can induce a long-lasting potentiation of synaptic transmission in the rat dentate gyrus in vitro. Here the authors provide further characterisation of this agonist-induced potentiation. 2. Field excitatory post-synaptic potentials were recorded from the denate gyrus of rat hippocampal slices prepared by standard methods. 3. (S)-DHPG (40 microM) induced a significant potentiation of the field EPSP slope (148.6 +/- 4.3% compared to controls, n = 5), which occluded tetanically-induced LTP. 4. This potentiation was inhibited by the PKC inhibitors staurosporine (0.1 microM) and H-7 (100 microM) and by the voltage dependent Ca2+ channel (VDCC) blockers NiCl2 (50 microM) and nifedipine (20 microM). 5. The mGluR5 specific agonist (RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) did not induce a potentiation when applied to slices at concentrations from 20 microM to 1 mM indicating that the (S)-DHPG potentiation may be mediated through group I subtype 1 mGluRs. 6. In conclusion the (S)-DHPG-induced potentiation observed in our studies may be PKC dependent and is likely to be mediated through both T/L subtype VDCC and mGluR1 subtype receptors.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
O'Leary DM,O'Connor JJdoi
10.1016/s0278-5846(98)00095-5subject
Has Abstractpub_date
1999-01-01 00:00:00pages
133-47issue
1eissn
0278-5846issn
1878-4216pii
S0278584698000955journal_volume
23pub_type
杂志文章abstract：:Emotion regulation by means of cognitive reappraisal has been widely studied with functional magnetic resonance imaging (fMRI). To date, several meta-analyses of studies using cognitive reappraisal tasks in healthy volunteers have been carried out, but no meta-analyses have yet been performed on the fMRI data of clini...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,meta分析,评审
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,meta分析
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更新日期：2013-08-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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更新日期：2011-08-15 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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更新日期：2012-01-10 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2005.08.010
更新日期：2005-12-01 00:00:00
