Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey.

Abstract:

:The COVID-19 pandemic has had far-ranging consequences for general physical and mental health. Country-specific research reveals a general reduction in mental and physical well-being, due to measures undertaken to stop the spread of COVID-19 disease. However, research is yet to examine the impact of the pandemic on global psychological distress and its effects upon vulnerable groups. Exploration of the factors that potentially mediate the relationship between stress and mental health during this period is needed, to assist in undertaking concrete measures to mitigate psychological distress and support vulnerable groups. Therefore, this study examined the impact of the COVID-19 pandemic on psychological distress globally, and identified factors that may exacerbate decline in mental health. N = 1653 participants (mean age 42.90 ± 13.63 years; 30.3% males) from 63 countries responded to the survey. Depression and anxiety were assessed using the Patient Health Questionnaire and State Trait Anxiety Inventory, respectively. Other measures included the Perceived Stress Scale, the Pittsburgh Sleep Quality Index, 3-item UCLA Loneliness Scale and the Brief Resilient Coping Scale. Globally, consistently high levels of stress, anxiety, depression and poor sleep were observed regardless of number of COVID-19 cases. Over 70% of the respondents had greater than moderate levels of stress, with 59% meeting the criteria for clinically significant anxiety and 39% reporting moderate depressive symptoms. People with a prior mental health diagnosis experienced greater psychological distress. Poor sleep, lower levels of resilience, younger age and loneliness significantly mediated the links between stress and depression, and stress and anxiety. Age-based differences revealed that younger age-groups were more vulnerable to stress, depression and anxiety symptoms. Results show that these vulnerable individuals need more support. Age-specific interventions for modifiable factors that mediate the psychological distress need to urgently deployed to address the global mental health pandemic.

authors

Varma P,Junge M,Meaklim H,Jackson ML

doi

10.1016/j.pnpbp.2020.110236

subject

Has Abstract

pub_date

2020-12-26 00:00:00

pages

110236

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(20)30552-2

journal_volume

109

pub_type

杂志文章
  • Phenomenology and neurobiology of cocaine withdrawal: are they related?

    abstract::1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluated in a group of 27 cocaine users three days after drug withdrawal. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigate...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(95)00194-8

    authors: Pathiraja A,Marazziti D,Cassano GB,Diamond BI,Borison RL

    更新日期:1995-10-01 00:00:00

  • ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a common and impairing disorder affecting millions of children, adolescents, and adults. Individuals with ADHD smoke cigarettes at rates significantly higher than their non-diagnosed peers and the disorder also confers risk for a number of related adverse smoking outc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2014.02.002

    authors: Kollins SH,Adcock RA

    更新日期:2014-07-03 00:00:00

  • Effects of antipsychotic D2 antagonists on long-term potentiation in animals and implications for human studies.

    abstract::In people with schizophrenia, cognitive abilities - including memory - are strongly associated with functional outcome. Long-term potentiation (LTP) is a form of neuroplasticity that is believed to be the physiological basis for memory. It has been postulated that antipsychotic medication can impair long-term potentia...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2014.05.001

    authors: Price R,Salavati B,Graff-Guerrero A,Blumberger DM,Mulsant BH,Daskalakis ZJ,Rajji TK

    更新日期:2014-10-03 00:00:00

  • 5-HT1A receptor responsivity in anxiety disorders and depression.

    abstract::1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0278-5846(91)90001-h

    authors: Lesch KP

    更新日期:1991-01-01 00:00:00

  • The association of excitation and inhibition signaling with the relative symptom expression of autism and psychosis-proneness: Implications for psychopharmacology.

    abstract::The underlying mechanisms of autism and schizophrenia are poorly understood, partly due to a lack of dimension-specific research. Aberrant excitatory and inhibitory neurotransmission are implicated in both conditions, particularly in social dysfunction. This study investigates the extent to which the degree of autisti...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2018.07.024

    authors: Ford TC,Abu-Akel A,Crewther DP

    更新日期:2019-01-10 00:00:00

  • Biological markers as classifiers for depression: a multivariate study.

    abstract::1. Delta TSH, REM latency, 4 pm and 11 pm post-dexamethasone cortisol values were determined after a wash-out period in a group of 74 non-selected depressed patients who were diagnosed (according to RDC with the SADS) as follows: 46 definite and 10 probable MD, 4 minor and 14 intermittent depression. 2. These biologic...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/0278-5846(94)90106-6

    authors: Staner L,Linkowski P,Mendlewicz J

    更新日期:1994-09-01 00:00:00

  • Aberrant emotional processing in posterior cortical midline structures in bipolar II depression.

    abstract::Bipolar II depression is a serious and disabling illness associated with significant impairment and high rates of suicide attempts. However, mechanisms underlying emotional dysregulation in this condition are poorly characterized. The goal of this work was to investigate one component of emotional processing in this d...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.05.017

    authors: Marchand WR,Lee JN,Garn C,Thatcher J,Gale P,Kreitschitz S,Johnson S,Wood N

    更新日期:2011-08-15 00:00:00

  • Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association.

    abstract::The aim of the present study was to develop an animal model for the study of depressive symptoms associated with Parkinson's disease (PD). Mice treated intraperitoneally with reserpine (RES), 2.0 and 1.0 mg/kg, or its vehicle (VEHIC) were submitted to the sucrose solution (2%) consumption test (a model employed to mim...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00333-5

    authors: Skalisz LL,Beijamini V,Joca SL,Vital MA,Da Cunha C,Andreatini R

    更新日期:2002-06-01 00:00:00

  • Effects of ageing on prefrontal temporal cortical network function in healthy volunteers as assessed by COWA. An exploratory survey.

    abstract::The prefrontal temporal cortical network (PFTCN) is a crucial part of a widely distributed neural network which has been shown (a) to subserve language function; (b) to modulate the cognitive circuits that are linked with work production; and (c) to organise thinking and develop word-search strategies. Dysfunction of ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00321-9

    authors: Dursun SM,Robertson HA,Bird D,Kutcher D,Kutcher SP

    更新日期:2002-06-01 00:00:00

  • Dependence potential of antidepressants compared to benzodiazepines.

    abstract::The aim of the present study was to compare the possible dependence potential of antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in Neuropsychiatry (SCAN), the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ) and the Symptom Checklist-90 (SCL-90) were administered...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(02)00209-9

    authors: van Broekhoven F,Kan CC,Zitman FG

    更新日期:2002-06-01 00:00:00

  • High trait anxiety in healthy subjects is associated with low neuroendocrine activity during psychosocial stress.

    abstract::Altered stress responsiveness has been repeatedly related to mood and anxiety disorders. In a traditional view, a reduction of the stress response has been thought favorable. The goal of the present study was to verify the hypothesis that high anxiety is accompanied by enhanced hormone release during stress. Healthy s...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2004.08.005

    authors: Jezova D,Makatsori A,Duncko R,Moncek F,Jakubek M

    更新日期:2004-12-01 00:00:00

  • The effects of sleep deprivation on microRNA expression in rats submitted to pilocarpine-induced status epilepticus.

    abstract::Epilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathophysiological mechani...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2014.02.001

    authors: Matos G,Scorza FA,Mazzotti DR,Guindalini C,Cavalheiro EA,Tufik S,Andersen ML

    更新日期:2014-06-03 00:00:00

  • Oscillatory potentials abnormalities in regular cannabis users: Amacrine cells dysfunction as a marker of central dopaminergic modulation.

    abstract:BACKGROUND:Cannabis is a neuromodulating substance that acts on central synaptic transmission. Regular cannabis use induces a decreased capacity for dopamine synthesis in the brain. The retina is considered an easy means of investigating dysfunctions of synaptic transmission in the brain. We have previously studied the...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110083

    authors: Polli L,Schwan R,Albuisson E,Malbos L,Angioi-Duprez K,Laprevote V,Schwitzer T

    更新日期:2020-08-27 00:00:00

  • EEG spectral power and mean frequencies in early heroin abstinence.

    abstract::The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships among electroencephalography (EEG) spectral power and mean frequencies and heroin abuse history. Eyes-closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin ab...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2003.09.022

    authors: Polunina AG,Davydov DM

    更新日期:2004-01-01 00:00:00

  • Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Frégoli symptoms.

    abstract::The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component o...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00293-7

    authors: Papageorgiou C,Lykouras L,Ventouras E,Uzunoglu N,Christodoulou GN

    更新日期:2002-05-01 00:00:00

  • Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.

    abstract::A number of neuroprotective effects of curcumin have been demonstrated in recent years. However, whether curcumin exerts any beneficial effects on age-related impaired cognition and memory has not been well characterized; nor was there any detailed data on the molecular pathways activated by curcumin. The present stud...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2013.05.001

    authors: Yu SY,Zhang M,Luo J,Zhang L,Shao Y,Li G

    更新日期:2013-08-01 00:00:00

  • Sertraline and rapid eye movement sleep without atonia: an 8-week, open-label study of depressed patients.

    abstract::Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) may induce or exacerbate rapid eye movement (REM) sleep without atonia (RSWA) and increase the risk of developing REM sleep behavior disorder (RBD). However, most of these studies are retrospective and cross-sectional and employed smal...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2013.08.010

    authors: Zhang B,Hao Y,Jia F,Tang Y,Li X,Liu W,Arnulf I

    更新日期:2013-12-02 00:00:00

  • 5-HT2C receptors in psychiatric disorders: A review.

    abstract::5-HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post-transcriptional editing could be involved in the pathophysiology of psychiatric disorders through impairment in G-protein interactions. Mor...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2015.12.006

    authors: Chagraoui A,Thibaut F,Skiba M,Thuillez C,Bourin M

    更新日期:2016-04-03 00:00:00

  • Estradiol, TRH and striatal dopaminergic mechanisms.

    abstract::1. Estrogens have been shown to decrease the effect of apomorphine in a variety of animal behavioral models reflecting the sensitivity of striatal and mesolimbic dopamine receptors. 2. These include circling, and locomotor activity, in rats and suppression of midbrain tremor as well as lingual dyskinesia in monkeys. 3...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(82)80149-8

    authors: Bédard PJ,Malouin F,Dipaolo T,Labrie F

    更新日期:1982-01-01 00:00:00

  • Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall.

    abstract:UNLABELLED:The capacity to discriminate between safety and danger is fundamental for survival, but is disrupted in individuals with posttraumatic stress disorder (PTSD). Acute stressors cause a release of serotonin (5-HT) in the forebrain, which is one mechanism for enhanced fear and anxiety; these effects are mediated...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.08.017

    authors: Foilb AR,Christianson JP

    更新日期:2016-02-04 00:00:00

  • Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia.

    abstract::The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the developm...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.05.032

    authors: Bergman O,Westberg L,Nilsson LG,Adolfsson R,Eriksson E

    更新日期:2010-08-16 00:00:00

  • Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.

    abstract::A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is also very high among depressed individuals. Because neuronal nicotinic receptors have been implicated in mood regulation as well as in reinforcing effects of a...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2008.09.010

    authors: Tizabi Y,Getachew B,Rezvani AH,Hauser SR,Overstreet DH

    更新日期:2009-04-30 00:00:00

  • Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.

    abstract:OBJECTIVE:Recently, traditional herbal medicines have been reported to be effective for behavioral and psychological symptoms of dementia (BPSD). This study aims to examine the efficacy of Yi-Gan San (YGS) in the improvement of BPSD and sleep disorders in patients with dementia. METHODS:Five patients (1 male and 4 fem...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2007.12.027

    authors: Shinno H,Inami Y,Inagaki T,Nakamura Y,Horiguchi J

    更新日期:2008-04-01 00:00:00

  • Effects of fencamfamine on latent inhibition.

    abstract::The effects of fencamfamine (FCF), an indirect dopamine (DA) agent, were investigated using the latent inhibition (LI) model of schizophrenia. In the LI procedure, rats preexposed (PE) to an unreinforced stimulus show difficulty in subsequent learning of an association in which that stimulus is predictive of an uncond...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(02)00241-5

    authors: Alves CR,Delucia R,Silva MT

    更新日期:2002-10-01 00:00:00

  • Dopaminergic regulation of glutamic acid decarboxylase mRNA expression and GABA release in the striatum: a review.

    abstract::1. The majority of neurons in the striatum (caudate-putamen, dorsal striatum; nucleus accumbens, ventral striatum) and in striatal projection regions (the pallidum, the entopeduncular nucleus and substantia nigra reticulata) use gamma-aminobutyric acid (GABA) as transmitter and express glutamic acid decarboxylase (GAD...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0278-5846(93)90018-n

    authors: Lindefors N

    更新日期:1993-11-01 00:00:00

  • Stimulatory effect of desipramine on lung metastases of adenocarcinoma MADB 106 in stress highly-sensitive and stress non-reactive rats.

    abstract::The effect of antidepressant drugs on tumor progress is very poorly recognized. The aim of the present study was to examine the effect of individual reactivity to stress and 24-day desipramine (DES) administration on the metastatic colonization of adenocarcinoma MADB 106 cells in the lungs of Wistar rats. Wistar rats ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2017.04.024

    authors: Grygier B,Kubera M,Wrona D,Roman A,Basta-Kaim A,Gruca P,Papp M,Rogoz Z,Leskiewicz M,Budziszewska B,Regulska M,Korzeniak B,Curzytek K,Glombik K,Slusarczyk J,Maes M,Lason W

    更新日期:2018-01-03 00:00:00

  • Chronic stimulation of the cat vagus nerve: effect on sleep and behavior.

    abstract::The effect of electrical vagus nerve stimulation (VNS) on sleep and behavior was analyzed in freely moving cats. Eight cats were prepared for 23-h sleep recordings. The left vagus nerve of four of them was stimulated during 1 min, five times at 1-h intervals, for 5 days. The VNS induces: ipsilateral myosis, blinking, ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00228-7

    authors: Valdés-Cruz A,Magdaleno-Madrigal VM,Martínez-Vargas D,Fernández-Mas R,Almazán-Alvarado S,Martínez A,Fernández-Guardiola A

    更新日期:2002-01-01 00:00:00

  • GABAB receptors are involved in the control of acute opiate withdrawal in isolated tissue.

    abstract::1. The effects exerted by GABAB receptor agonists and antagonists on the acute opiate withdrawal induced by mu and k receptor agonists were investigated in vitro. 2. Following a 4 min in vitro exposure to morphine (less selective mu agonist), DAGO (highly selective mu agonist) and U50-488H (highly selective k agonist)...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(98)00097-9

    authors: Capasso A

    更新日期:1999-02-01 00:00:00

  • Sex differences in corticolimbic dopamine and serotonin systems in the rat and the effect of postnatal handling.

    abstract::Stress-related psychopathology is particularly prevalent in women, although the neurobiological reason(s) for this are unclear. Dopamine (DA) and serotonin (5-HT) systems however, are known to play important adaptive roles in stress and emotion regulation. The aims of the present study included examination of sex diff...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2008.11.012

    authors: Duchesne A,Dufresne MM,Sullivan RM

    更新日期:2009-03-17 00:00:00

  • Plasma level of brain-derived neurotrophic factor (BDNF) in patients with postpartum depression.

    abstract::Postpartum depression occurs in 10-15% of mothers. Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays a role in neuroplasticity. We hypothesized that the concentration of BDNF is related to reproduction and childbirth, and that women with postpartum depression show alteration in BDNF level. A...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2021.110245

    authors: Lee Y,Kim KH,Lee BH,Kim YK

    更新日期:2021-01-11 00:00:00