Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease.

Abstract:

:Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive impairment (MCI), which refers to a transitional state between the cognition of normal aeging and mild dementia regarded as a high-risk condition for the development of clinically probable Alzheimer's disease (AD). Computerized tests of memory, attention and executive functions were studied in groups of AD subjects (n=15) and MCI subjects (n=25). On all measures, the performance of the AD group was significantly weaker compared to healthy individuals or to the MCI group. The performance of both the AD and MCI patients in the Paired Associate Learning test was significantly impaired, which may suggest that MCI patients are already in the early stages of the disease.

authors

Egerházi A,Berecz R,Bartók E,Degrell I

doi

10.1016/j.pnpbp.2007.01.011

subject

Has Abstract

pub_date

2007-04-13 00:00:00

pages

746-51

issue

3

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(07)00021-8

journal_volume

31

pub_type

杂志文章
  • ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a common and impairing disorder affecting millions of children, adolescents, and adults. Individuals with ADHD smoke cigarettes at rates significantly higher than their non-diagnosed peers and the disorder also confers risk for a number of related adverse smoking outc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2014.02.002

    authors: Kollins SH,Adcock RA

    更新日期:2014-07-03 00:00:00

  • Evaluation of cyclic AMP accumulation in EBV-transformed human B-lymphocytes: effects of dopamine agonists, isoproterenol, prostaglandin E1, cholera toxin, forskolin, and phorbol 12-myristate-13 acetate.

    abstract::1. Phorbol 12-myristate-13-acetate (PMA), a protein kinase C activator, elevated cyclic AMP accumulation in EBV-transformed human B-lymphocytes, and potentiated isoproterenol-, prostaglandin- (PGE1), cholera toxin-, and forskolin-stimulated cyclic AMP accumulation. 2. The dopamine D1 receptor agonist, SKF38393 (10(-7)...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(95)00295-2

    authors: Natsukari N,Kulaga H,Baker I,Wyatt RJ,Masserano JM

    更新日期:1996-01-01 00:00:00

  • Neuropathological relationship between major depression and dementia: A hypothetical model and review.

    abstract::Major depression (MDD) is a chronic psychiatric condition in which patients often show increasing cognitive impairment with recurring episodes. Neurodegeneration may play an important component in the pathogenesis of MDD associated with cognitive complaints. In agreement with this, patients with MDD show decreased bra...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2016.01.008

    authors: Kim HK,Nunes PV,Oliveira KC,Young LT,Lafer B

    更新日期:2016-06-03 00:00:00

  • Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.

    abstract::1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(97)00042-0

    authors: Walden J,von Wegerer J,Winter U,Berger M,Grunze H

    更新日期:1997-05-01 00:00:00

  • The interaction of ASAH1 and NGF gene involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility and psychopathology.

    abstract::The neurodevelopmental hypothesis of schizophrenia has been widely accepted. In light of our previous microarray data, two neurodevelopment-related genes were focused on inclduing the N-acylsphingosine amidohydrolase 1 gene (ASAH1) and the nerve growth factor gene (NGF). The evidence that ASAH1 and NGF are associated ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110015

    authors: Su Y,Yang L,Li Z,Wang W,Xing M,Fang Y,Cheng Y,Lin GN,Cui D

    更新日期:2021-01-10 00:00:00

  • International regulation of benzodiazepines.

    abstract::1. The UN Convention 1971 on Psychotic substances requires the World Health Organization to recommend psychotropic substances for international control. 2. This convention is based on evaluating the benefit and risk ratio, in particular on the public health and social problems associated with its use. 3. The UN Commis...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0278-5846(92)90003-w

    authors: Khan I

    更新日期:1992-01-01 00:00:00

  • Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats.

    abstract::Physical exercise protocols have varied widely across studies raising the question of whether there is an optimal intensity, duration and frequency that would produce maximal benefits in attenuating symptoms related to anxiety disorders. Although physical exercise causes modifications in neurotransmission systems, the...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.10.015

    authors: Costa MS,Ardais AP,Fioreze GT,Mioranzza S,Botton PH,Portela LV,Souza DO,Porciúncula LO

    更新日期:2012-01-10 00:00:00

  • Understanding facial expressivity in autism spectrum disorder: An inside out review of the biological basis and clinical implications.

    abstract::Deficits in decoding and understanding facially expressed emotions occur commonly in persons with autism spectrum disorder (ASD), which contribute to the impairment of social communication that serves as one of its core diagnostic criteria. Research suggests that abnormalities of visual scanning of the face, activatio...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2018.05.009

    authors: Deutsch SI,Raffaele CT

    更新日期:2019-01-10 00:00:00

  • Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.

    abstract::Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool befor...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(85)90191-5

    authors: Marcy R,Quermonne MA,Raoul J,Nammathao B,Smida A

    更新日期:1985-01-01 00:00:00

  • Anxiety and beta-adrenergic receptor function in a normal population.

    abstract::Many studies have shown a close relationship between anxiety and beta-adrenergic receptor function in patients with anxiety disorders. This study examined the relationship between beta-adrenergic receptor function and anxiety levels in a normal population. Subjects for this study included 36 men and 44 women between t...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2005.04.027

    authors: Kang EH,Yu BH

    更新日期:2005-06-01 00:00:00

  • Novel therapeutic targets in mood disorders: Pentoxifylline (PTX) as a candidate treatment.

    abstract::Numerous pharmacological treatments for mood disorders are currently available; however, rates of treatment resistance, relapse and recurrence remain high. Therefore, novel treatments acting outside of the conventionally targeted monoamine system are urgently needed to improve patient outcomes. Emerging and converging...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2020.110032

    authors: Siegel AN,Rodrigues N,Nasri F,Wilkialis L,Lipsitz O,Lee Y,Gill H,Subramaniapillai M,Phan L,Majeed A,Lui LMW,Rashidian H,Ho R,Toma S,Goldstein BI,Mansur RB,McIntyre RS,Rosenblat JD

    更新日期:2021-01-10 00:00:00

  • Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder.

    abstract::Power spectral analysis of electrocardiogram (ECG) R-R intervals is useful for the detection of autonomic dysfunction in various clinical disorders. Although both panic disorder (PD) and major depressive disorder (MDD) are known to have effects on the cardiac autonomic nervous system, no previous study has tested this...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.08.002

    authors: Kikuchi M,Hanaoka A,Kidani T,Remijn GB,Minabe Y,Munesue T,Koshino Y

    更新日期:2009-11-13 00:00:00

  • Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers.

    abstract::Depression and impaired quality of life (QOL) are frequently observed in patients suffering from a variety of diseases. In addition, it has been reported that an enhanced degradation of the serotonin precursor tryptophan may contribute to QOL deterioration in some diseases. However, it is unclear whether the correlati...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.03.018

    authors: Tsai HC,Yeh TL,Hsieh MH,Lee IH,Chen KC,Chen PS,Yang YK,Yao WJ

    更新日期:2009-06-15 00:00:00

  • The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders.

    abstract::1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxyphenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined. The same relationships apply fo...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90025-v

    authors: Davis BA,Durden DA,O'Reilly RL

    更新日期:1991-01-01 00:00:00

  • Effects of olanzapine on aggressiveness in heroin dependent patients.

    abstract::This study compared the anti-aggressiveness effects of the atypical anti-psychotic olanzapine with that of selective serotonin reuptake inhibitors (SSRI) and benzodiazepines (BZD) among patients with heroin dependence submitted to opioid-agonists substitution treatment. Sixty-seven (67) patients who met the DSM-IV cri...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.pnpbp.2006.04.023

    authors: Gerra G,Di Petta G,D'Amore A,Iannotta P,Bardicchia F,Falorni F,Coacci A,Strepparola G,Campione G,Lucchini A,Vedda G,Serio G,Manzato E,Antonioni M,Bertacca S,Moi G,Zaimovic A

    更新日期:2006-09-30 00:00:00

  • Alcohol and visual performance.

    abstract::1. The authors examined the effect of acute alcohol consumption on a set of visual tasks: visual short term memory, depth perception, and attention. 2. In a repeated measurement design, thirteen subjects performed the tasks once sober and once intoxicated with 0.8 g/kg body weight pure ethanol in orange juice (33% alc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(99)00009-3

    authors: Wegner AJ,Fahle M

    更新日期:1999-04-01 00:00:00

  • Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relati...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.08.002

    authors: Bae KY,Kim DW,Im CH,Lee SH

    更新日期:2011-12-01 00:00:00

  • Neurocognitive function in borderline personality disorder.

    abstract::A battery of neuropsychological measures considered sensitive to dysfunction in prefrontal or temporal cortices was administered to patients with borderline personality disorder (BPD) and healthy controls. BPD patients exhibited striking deficits on measures of nonverbal executive function and nonverbal memory but wer...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2003.10.012

    authors: Dinn WM,Harris CL,Aycicegi A,Greene PB,Kirkley SM,Reilly C

    更新日期:2004-03-01 00:00:00

  • The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.

    abstract::1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(95)00234-0

    authors: Lau SM,Tang F

    更新日期:1995-11-01 00:00:00

  • The value of cytidine-5-diphosphate-choline in the prevention of impairment of memory function after electric convulsive therapy. A double-blind study.

    abstract::1. A double-blind study of the effect of CDP-choline on memory impairment following bilateral ECT was performed on 22 inpatients suffering from endogenous depression. 2. Memory scores were checked after 2 and 4 ECT sessions, and the length of the post-ECT confusional state was also measured. 3. The results show no sta...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0278-5846(82)80174-7

    authors: Ayuso-Gutierrez JL,Saiz-Ruiz J

    更新日期:1982-01-01 00:00:00

  • Type I tardive dyskinesia induced by anticholinergic drugs, dopamine agonists and neuroleptics.

    abstract::1. Type I risk factor for tardive dyskinesia is defined as a risk leading primarily to a reversible form, while Type II factors to irreversible forms. 2. Central anticholinergic drugs appear as the prototype of Type I drug factor which increased the clinical manifestations of the disorder, but not its overall incidenc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(82)80151-6

    authors: Chouinard G,Steinberg S

    更新日期:1982-01-01 00:00:00

  • Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall.

    abstract:UNLABELLED:The capacity to discriminate between safety and danger is fundamental for survival, but is disrupted in individuals with posttraumatic stress disorder (PTSD). Acute stressors cause a release of serotonin (5-HT) in the forebrain, which is one mechanism for enhanced fear and anxiety; these effects are mediated...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.08.017

    authors: Foilb AR,Christianson JP

    更新日期:2016-02-04 00:00:00

  • Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine.

    abstract::The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical respons...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2016.12.003

    authors: Gassó P,Rodríguez N,Blázquez A,Monteagudo A,Boloc D,Plana MT,Lafuente A,Lázaro L,Arnaiz JA,Mas S

    更新日期:2017-04-03 00:00:00

  • Significance of gastrointestinal tract in the therapeutic mechanisms of exercise in depression: Synchronism between brain and intestine through GBA.

    abstract::Researchers have made considerable progress in elucidating psychological and exercise correlates of major depressive disorder (MDD). However, as the largest immune organ, far less is known about the role of gastrointestinal (GI) tract in the therapeutic mechanisms of exercise in MDD. In addition to the sites of the di...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.109971

    authors: Liu Y,Xu F,Liu S,Liu G,Yang X,Gao W,Fan K,Zhao H,Ma J

    更新日期:2020-12-20 00:00:00

  • Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.

    abstract::In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. A d...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/s0278-5846(01)00192-0

    authors: Allison AC,Cacabelos R,Lombardi VR,Alvarez XA,Vigo C

    更新日期:2001-10-01 00:00:00

  • Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder.

    abstract:OBJECTIVE:Bipolar disorder is associated with a high risk of suicide. Many clinical characteristics and, recently, biomarkers have been studied with the aim to find useful predictors of suicidality. The role of serum lipids has also been explored albeit with conflicting results; however, few studies have been focused o...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.12.009

    authors: D'Ambrosio V,Salvi V,Bogetto F,Maina G

    更新日期:2012-04-27 00:00:00

  • Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.

    abstract:OBJECTIVE:To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable risk. MATRIAL AND METHODS:In a high-risk study, 234 healthy monozygotic ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2013.10.007

    authors: Vinberg M,Miskowiak K,Kessing LV

    更新日期:2014-01-03 00:00:00

  • Propranolol in schizophrenia.

    abstract::1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS star...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(83)90093-3

    authors: Sethi BB,Dubé S

    更新日期:1983-01-01 00:00:00

  • S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice.

    abstract::S 47445 is a positive allosteric modulator of glutamate AMPA-type receptors that possesses procognitive, neurotrophic and enhancing synaptic plasticity properties. Its chronic administration promotes antidepressant- and anxiolytic-like effects in different rodent models of depression. We have evaluated the behavioral ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2019.04.005

    authors: Pilar-Cuellar F,Castro E,Bretin S,Mocaer E,Pazos Á,Díaz Á

    更新日期:2019-07-13 00:00:00

  • Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.

    abstract::Post-mortem studies of the human brain indicate that certain GABA(A) receptor subtypes may be differentially altered in schizophrenia. Increased binding to the total population of GABA(A) receptors using [3H]muscimol is observed in the post-mortem schizophrenic brain, yet a proportion of these receptors which bind ben...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.10.003

    authors: Skilbeck KJ,O'Reilly JN,Johnston GA,Hinton T

    更新日期:2008-02-15 00:00:00