Abstract:
:1. Phorbol 12-myristate-13-acetate (PMA), a protein kinase C activator, elevated cyclic AMP accumulation in EBV-transformed human B-lymphocytes, and potentiated isoproterenol-, prostaglandin- (PGE1), cholera toxin-, and forskolin-stimulated cyclic AMP accumulation. 2. The dopamine D1 receptor agonist, SKF38393 (10(-7) to 10(-5) MH, had no effect on cyclic AMP accumulation in transformed human B-lymphocytes. 3. The dopamine D2 receptor agonist, quinpirole (10(-7) to 10(-5) MH did not inhibit cyclic AMP accumulation even when cyclic AMP accumulation was maximized by the addition of PMA and forskolin. 4. These data suggest that dopamine D1- and D2-receptor coupling to a cyclic AMP generating system is not present at detectable levels in transformed human B-lymphocytes.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Natsukari N,Kulaga H,Baker I,Wyatt RJ,Masserano JMdoi
10.1016/0278-5846(95)00295-2subject
Has Abstractpub_date
1996-01-01 00:00:00pages
99-108issue
1eissn
0278-5846issn
1878-4216pii
0278584695002952journal_volume
20pub_type
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