当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices.

Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices.

Abstract：

:The neuropeptide substance P (SP) has been suggested to be involved in several physiological and pathological conditions including learning and memory and the processing of pain. This study investigated for the first time acute effects of SP and the neurokinin-1 (NK-1) receptor antagonist L-733060 on long term potentiation (LTP) in the hippocampus. Electrically evoked fEPSP was tested under the influence of SP in the CA1 region of the guinea pig hippocampus. Concentrations of 1 and 10 microM SP increased fEPSP slopes to 114.3+/-4.5% and 115.8+/-2.7%, respectively. A threshold concentration was found at 0.1 microM SP. The SP-specific NK-1 receptor antagonist L-733060 did not influence fEPSP in a concentration of 1 microM. In experiments with LTP, a significant increase of potentiations after 60 min was seen with 1 microM SP. Even if the initial baseline increase due to SP (1 microM) was subtracted, potentiations were bigger compared to controls. L-733060 (1 microM) suppressed the excitatory effects of 1 microM SP nearly complete and subsequent induced LTP was not increased. In conclusion, SP has excitatory effects in the hippocampus and is able to facilitate LTP via activation of the NK-1 receptor.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Langosch JM,Kupferschmid S,Heinen M,Walden J,Herpfer I,Fiebich BL,Lieb K

doi

10.1016/j.pnpbp.2004.11.017

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

315-9

issue

2

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(04)00259-3

journal_volume

29

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder.

    abstract：:Power spectral analysis of electrocardiogram (ECG) R-R intervals is useful for the detection of autonomic dysfunction in various clinical disorders. Although both panic disorder (PD) and major depressive disorder (MDD) are known to have effects on the cardiac autonomic nervous system, no previous study has tested this...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.08.002

    authors： Kikuchi M,Hanaoka A,Kidani T,Remijn GB,Minabe Y,Munesue T,Koshino Y

    更新日期：2009-11-13 00:00:00

  • Clinical clues to the aetiology of puerperal psychosis.

    abstract：:Recent case reports of postpartum psychosis are reviewed, which suggest hypotheses for the aetiology of this disease. The main themes are: The relationship to manic depression. Premenstrual relapse. Prepartum onset. Onset after miscarriage or evacuation of a trophoblastic tumour. Onset after bromocriptine treatment. A...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(94)90001-9

    authors： Brockington IF,Meakin CJ

    更新日期：1994-05-01 00:00:00

  • Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole.

    abstract：:The clinical efficacy of aripiprazole in the treatment of psychosis relies on a partial agonism at D2 receptors. As the expression of this receptor differs physiologically between pre- and post-synaptic sites and is affected by pathological conditions or pharmacological treatments, it appears difficult to predict the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.08.007

    authors： Koener B,Focant MC,Bosier B,Maloteaux JM,Hermans E

    更新日期：2012-01-10 00:00:00

  • Neurotoxic effects of amphetamine plus L-DOPA.

    abstract：:1. Male Swiss Webster mice were administered a series of amphetamine injections preceded by either saline or L-DOPA. 2. This injection regimen was performed for either one, two or three consecutive weeks and neurotoxic effects of the drugs were determined one week later. 3. Amphetamine treatment for two weeks produced...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00031-7

    authors： Myers CS,Halladay AK,Widmer DA,Wagner GC

    更新日期：1999-05-01 00:00:00

  • Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesian Chinese Han patients with schizophrenia.

    abstract：OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.12.007

    authors： Wang F,Fan H,Sun H,Yang F,Luo Y,Liu H,Kosten TR,Lu L,Zhang XY

    更新日期：2012-04-27 00:00:00

  • Pharmacogenetics of antidepressant response: A polygenic approach.

    abstract：BACKGROUND:Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across g...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.01.011

    authors： García-González J,Tansey KE,Hauser J,Henigsberg N,Maier W,Mors O,Placentino A,Rietschel M,Souery D,Žagar T,Czerski PM,Jerman B,Buttenschøn HN,Schulze TG,Zobel A,Farmer A,Aitchison KJ,Craig I,McGuffin P,Giupponi M,

    更新日期：2017-04-03 00:00:00

  • Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.

    abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.010

    authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

    更新日期：2019-03-08 00:00:00

  • A survey of prescribing practices in the treatment of depression.

    abstract：BACKGROUND:With the increasing number and type of antidepressants available to clinicians, there is a need to better understand current prescribing practices and to what degree these practices reflect research findings. The purpose of this study was to examine prescribing practices in a sample of psychiatrists attendin...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00250-0

    authors： Petersen T,Dording C,Neault NB,Kornbluh R,Alpert JE,Nierenberg AA,Rosenbaum JF,Fava M

    更新日期：2002-01-01 00:00:00

  • Strain-dependent modification of behavior following antidepressant treatment.

    abstract：:The effects of repeated antidepressant drug treatment on behavioral outcome in Wistar Kyoto (WKY) rats, a putative animal model of depressive behavior, were compared to Wistar and Sprague-Dawley (SD) rats. Rats were treated with desipramine (norepinephrine [NE] uptake blocker), nomifensine (NE and dopamine [DA] uptake...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00308-1

    authors： Tejani-Butt S,Kluczynski J,Paré WP

    更新日期：2003-02-01 00:00:00

  • Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder.

    abstract：OBJECTIVE:Bipolar disorder is associated with a high risk of suicide. Many clinical characteristics and, recently, biomarkers have been studied with the aim to find useful predictors of suicidality. The role of serum lipids has also been explored albeit with conflicting results; however, few studies have been focused o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.12.009

    authors： D'Ambrosio V,Salvi V,Bogetto F,Maina G

    更新日期：2012-04-27 00:00:00

  • Neurocognitive function in borderline personality disorder.

    abstract：:A battery of neuropsychological measures considered sensitive to dysfunction in prefrontal or temporal cortices was administered to patients with borderline personality disorder (BPD) and healthy controls. BPD patients exhibited striking deficits on measures of nonverbal executive function and nonverbal memory but wer...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.012

    authors： Dinn WM,Harris CL,Aycicegi A,Greene PB,Kirkley SM,Reilly C

    更新日期：2004-03-01 00:00:00

  • Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.

    abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90084-r

    authors： Akil M,Lewis DA

    更新日期：1992-05-01 00:00:00

  • Metabolism of antidepressants: urinary metabolites of trimipramine in the rat.

    abstract：:1. Studies on the metabolism of the tricyclic antidepressant trimipramine (TMP) in the rat are described. 2. Twenty metabolites of TMP were isolated from rat urine after enzymatic hydrolysis and their structures were determined by a gas chromatographic-mass spectrometric (GC-MS) method. 3. Twelve TMP metabolites were ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90094-h

    authors： Hussain MS,Coutts RT,Baker GB,Micetich RG,Daneshtalab M

    更新日期：1991-01-01 00:00:00

  • Effects of chronic nicotine on the temporal structure of anxiety-related behavior in rats tested in hole-board.

    abstract：:The present study aimed to assess the behavioral effects of chronic treatments of different doses of nicotine by using both quantitative and multivariate T-pattern analysis (TPA), which can reveal hidden behavioral structures, in Sprague-Dawley rats tested in the hole-board apparatus. To this purpose, nicotine ditartr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109731

    authors： Casarrubea M,Pierucci M,Aiello S,Cassar D,Deidda G,Crescimanno G,Di Giovanni G

    更新日期：2020-01-10 00:00:00

  • Stimulatory effect of butoctamide hydrogen succinate on REM sleep in normal humans.

    abstract：:1. The efficacy of butoctamide hydrogen succinate (BAHS) was compared with that of nitrazepam on the basis of the polysomnograms and the subjective assessments. 2. Twelve healthy male students were divided into three groups consisting of 4 subjects each with were administered BAHS 600 mg, nitrazepam 5 mg, and BAHS 600...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(95)00020-v

    authors： Mizuki Y,Suetsugi M,Hotta H,Ushijima I,Yamada M

    更新日期：1995-05-01 00:00:00

  • An MRI study of the basal ganglia in autism.

    abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00020-2

    authors： Sears LL,Vest C,Mohamed S,Bailey J,Ranson BJ,Piven J

    更新日期：1999-05-01 00:00:00

  • Behavioral modifications in relation to hypothyroidism and hyperthyroidism in adult rats.

    abstract：:1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90044-4

    authors： Fundaro A

    更新日期：1989-01-01 00:00:00

  • The organization of chemically-identified neural systems in monkey prefrontal cortex: afferent systems.

    abstract：:1. Immunohistochemical methods were used to identify dopaminergic, noradrenergic, cholinergic and serotonergic axons in cynomolgus monkey prefrontal cortex. 2. The densities of dopaminergic and noradrenergic systems varied in a similar fashion across prefrontal cortical regions, whereas the densities of cholinergic an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(90)90025-c

    authors： Lewis DA

    更新日期：1990-01-01 00:00:00

  • Sustained attention deficits in manic and euthymic patients with bipolar disorder.

    abstract：:Sustained attention deficits are proposed to be both state and trait indicators of bipolar disorder. The nature of these deficits and their association with medication and symptoms is not clear yet. The aim of this study was to investigate the impairments in various components of sustained attention task in euthymic a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.04.016

    authors： Bora E,Vahip S,Akdeniz F

    更新日期：2006-08-30 00:00:00

  • Role of state-dependency in memory impairment induced by acute administration of midazolam in mice.

    abstract：:Although the memory deficits produced by pre-training benzodiazepines administration have been extensively demonstrated both in humans and in animal studies, there is considerable controversy about the involvement of the state-dependency phenomenon on benzodiazepines-induced anterograde amnesia. The present study aime...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.01.013

    authors： Sanday L,Zanin KA,Patti CL,Tufik S,Frussa-Filho R

    更新日期：2012-04-27 00:00:00

  • P300 event-related potentials in probable dissociative generalized amnesia.

    abstract：:1. To investigate whether abnormalities in objective neurophysiologic measures are observable in patients with probable dissociative generalized amnesia, the P300 and N100 event-related potentials were evaluated in six such patients in both acute stage and after recovery from amnesia. Findings were compared with those...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00068-8

    authors： Fukuzako H,Fukuzaki S,Fukuzako T,Jing H,Ueyama K,Takigawa M

    更新日期：1999-11-01 00:00:00

  • The value of cytidine-5-diphosphate-choline in the prevention of impairment of memory function after electric convulsive therapy. A double-blind study.

    abstract：:1. A double-blind study of the effect of CDP-choline on memory impairment following bilateral ECT was performed on 22 inpatients suffering from endogenous depression. 2. Memory scores were checked after 2 and 4 ECT sessions, and the length of the post-ECT confusional state was also measured. 3. The results show no sta...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0278-5846(82)80174-7

    authors： Ayuso-Gutierrez JL,Saiz-Ruiz J

    更新日期：1982-01-01 00:00:00

  • Notch1 knockdown disturbed neural oscillations in the hippocampus of C57BL mice.

    abstract：:Neural oscillations and their interactions are associated with the coordination of neural groups, which provide a mechanism underlying information processing of brain functions. Notch1 receptor is involved in the neurological and psychiatric disorders, such as neurodevelopmental deficits, cerebral ischemia, Alzheimer'...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.01.019

    authors： Li Q,Zhang X,Cheng N,Yang C,Zhang T

    更新日期：2018-06-08 00:00:00

  • The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.

    abstract：BACKGROUND:Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2018.01.021

    authors： Arnone D,Wise T,Walker C,Cowen PJ,Howes O,Selvaraj S

    更新日期：2018-06-08 00:00:00

  • Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy.

    abstract：:Little is known about biological predictors of treatment response in panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the putative common etiolog...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.04.010

    authors： Kobayashi K,Shimizu E,Hashimoto K,Mitsumori M,Koike K,Okamura N,Koizumi H,Ohgake S,Matsuzawa D,Zhang L,Nakazato M,Iyo M

    更新日期：2005-06-01 00:00:00

  • Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine.

    abstract：:We have previously shown that acute stress-induced release of norepinephrine (NE) facilitates anxiety-like behavioral responses to stress, such as reduction in open-arm exploration on the elevated-plus maze and in social behavior on the social interaction test. Since these responses represent inhibition of ongoing beh...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.11.015

    authors： Bondi CO,Barrera G,Lapiz MD,Bedard T,Mahan A,Morilak DA

    更新日期：2007-03-30 00:00:00

  • Alcohol and visual performance.

    abstract：:1. The authors examined the effect of acute alcohol consumption on a set of visual tasks: visual short term memory, depth perception, and attention. 2. In a repeated measurement design, thirteen subjects performed the tasks once sober and once intoxicated with 0.8 g/kg body weight pure ethanol in orange juice (33% alc...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00009-3

    authors： Wegner AJ,Fahle M

    更新日期：1999-04-01 00:00:00

  • Slow magnetic stimulation of prefrontal cortex in depression and schizophrenia.

    abstract：:1. The authors used transcranial magnetic stimulation (TMS) of pre-frontal cortex to study mood changes in 10 depressed patients and 10 schizophrenic patients. 2. A slow rate of stimuli was used, one per 30 seconds; maximal intensity of about 2 Tesla was given for 30 stimuli, 15 on each side of the brain. 3. No side e...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(96)00161-3

    authors： Geller V,Grisaru N,Abarbanel JM,Lemberg T,Belmaker RH

    更新日期：1997-01-01 00:00:00

  • Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment.

    abstract：:1. The role of Gi-proteins on cataleptic responses induced by SCH23390 and haloperidol in chronic cocaine-treated mice was examined by intracerebroventricullor (i.c. v.) and intravenous (i. v.) injections of pertussis toxin (PTX), which catalyzes adenosine diphosphate (ADP)-ribosylation of Gi-proteins. 2. In animals p...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(00)00134-2

    authors： Ushijima I,Mizuki Y,Kobayashi T,Aoki T,Suetsugi M,Usami K,Watanabe Y

    更新日期：2000-11-01 00:00:00

  • Differential expression of mitogen-activated protein kinases and immediate early genes fos and jun in thalamus in schizophrenia.

    abstract：:Despite a growing body of evidence demonstrating that mitogen-activated protein (MAP) kinase pathways play an important physiological role in the CNS, little is known about their role and function in various mental disorders including schizophrenia. Our previous studies have shown increased expression of several inter...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.05.017

    authors： Kyosseva SV

    更新日期：2004-09-01 00:00:00