Sustained attention deficits in manic and euthymic patients with bipolar disorder.

abstract：:The aim of the present study was to evaluate the putative antidepressive and cognitive enhancer effects of phosphatidylserine (BC-PS). The antidepressive effect of BC-PS (50, 100 or 200 mg/kg), compared to saline or imipramine (IMI; 25 mg/kg), was studied in the forced swimming test in rats. These drugs were administe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Castilho JC,Perry JC,Andreatini R,Vital MA

更新日期：2004-07-01 00:00:00

abstract：:1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA, L-glutamate, aspartate, and other dicarboxylic amino acids; ii) glycine, D-serine, D-cycloserine, and others; iii) the p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lehmann J,Colpaert F,Canton H

更新日期：1991-01-01 00:00:00

abstract：:Atypical antipsychotics, including olanzapine, were originally expected to reduce the risk of haematological toxicity and to be safe alternatives to clozapine. We report a case of patient who developed leucopenia and neutropenia during treatment with olanzapine. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Stergiou V,Bozikas VP,Garyfallos G,Nikolaidis N,Lavrentiadis G,Fokas K

更新日期：2005-07-01 00:00:00

abstract：:1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Miller CH,Hummer M,Pycha R,Fleischhacker WW

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

更新日期：2019-03-08 00:00:00

abstract：:1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition allegedly involves an important modification of acute phase plasma protein (APP) equilibrium. 2. In order to elucidate whe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Maes M,Scharpe S,Bosmans E,Vandewoude M,Suy E,Uyttenbroeck W,Cooreman W,Vandervorst C,Raus J

更新日期：1992-07-01 00:00:00

abstract：:Endogenous cannabinoid ligands and cannabinoid CB1 receptor agonists have been shown to exert anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Andres-Mach M,Zolkowska D,Barcicka-Klosowska B,Haratym-Maj A,Florek-Luszczki M,Luszczki JJ

更新日期：2012-12-03 00:00:00

abstract：:Chronic ingestion of ethyl alcohol in pre-weanling rats can decrease whole-brain levels of sialic acid (SA), an acidic sugar that serves as terminal groups on glycolipids (gangliosides) and glycoproteins. Because SA occurs in both classes of membrane-bound chemicals, the alcohol effect could be on either or both paren...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Klemm WR,Foster DM

更新日期：1986-01-01 00:00:00

abstract：:1. Disruption of calcium homeostasis during neurodegenerative diseases is known to trigger apoptotic or necrotic death in neuronal cells. Recently, the authors reported that intracellular calcium restriction by NMDA receptor antagonists induces apoptosis in cortical cultures. To evaluate whether further restriction of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wie MB,Koh JY,Won MH,Lee JC,Shin TK,Moon CJ,Ha HJ,Park SM,Kim HC

更新日期：2001-11-01 00:00:00

abstract：:Neurodevelopmental factors have been implicated in the pathophysiology of mental disorders. However, the evidence regarding their role in bipolar disorder is controversial. We reviewed the pertinent literature searching for evidence regarding a neurodevelopmental origin of bipolar disorder. Findings from clinical, epi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sanches M,Keshavan MS,Brambilla P,Soares JC

更新日期：2008-10-01 00:00:00

abstract：:Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to affect convulsant activity in some animal models of seizures and epilepsy. Moreover, its influence on the protective activity of some antiepileptic drugs (AEDs) was also noted. The aim of the present study was to investigate th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nieoczym D,Socała K,Luszczki JJ,Czuczwar SJ,Wlaź P

更新日期：2012-10-01 00:00:00

abstract：:1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fundaro A

更新日期：1989-01-01 00:00:00

abstract：:Latent inhibition (LI) is a behavioural paradigm in which repeated exposure to a stimulus without consequence inhibits the formation of any new associations with that stimulus. To the extent that LI reflects a process of leaming to ignore irrelevant stimuli, disrupted LI has been suggested as an animal model for the a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gracey DJ,Bell R,King DJ

更新日期：2002-04-01 00:00:00

abstract：:Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged or unnecessary cells, such as those resulting from DNA damage or during development. There are many factors that contribute to this process, each demonstrating specificity of function, regulation, and pathway invo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ashe PC,Berry MD

更新日期：2003-04-01 00:00:00

abstract：:The authors investigated the impact of the CYP2D6 genotypes on the plasma concentration of paroxetine (PAX) in 55 Japanese psychiatric patients. They were administered 10 to 40 mg/day (24+/-10.0 mg/day) of PAX and maintained at the same daily dose for at least two weeks to obtain the steady-state concentrations. The p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ueda M,Hirokane G,Morita S,Okawa M,Watanabe T,Akiyama K,Shimoda K

更新日期：2006-05-01 00:00:00

abstract：:There is strong evidence that oxygen free radicals may play an important role in the pathophysiology of schizophrenia. Impaired antioxidant defense and increased lipid peroxidation have been previously reported in drug-naïve, first episode and chronically medicated schizophrenic patients using typical neuroleptics. We...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gama CS,Salvador M,Andreazza AC,Kapczinski F,Silva Belmonte-de-Abreu P

更新日期：2006-05-01 00:00:00

abstract：:We explored whether the elevation of RBC-choline and choline ratio (RBC-choline/plasma-choline) by lithium is a specific effect of lithium, whether these choline parameters are characteristics of the individual patient, and whether they are related to prophylactic lithium response. In lithium-treated patients RBC-chol...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Haag M,Granzow L,Greil W,Haag H

更新日期：1987-01-01 00:00:00

abstract：:The present study aims to evaluate the effects of pterostilbene on lipopolysaccharide (LPS)-induced learning and memory impairment as well as the possible changes of microglia and neurons. Firstly, learning and memory function was investigated by behavioral tests. Pterostilbene attenuated LPS-induced learning and memo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hou Y,Xie G,Miao F,Ding L,Mou Y,Wang L,Su G,Chen G,Yang J,Wu C

更新日期：2014-10-03 00:00:00

abstract：:S 47445 is a positive allosteric modulator of glutamate AMPA-type receptors that possesses procognitive, neurotrophic and enhancing synaptic plasticity properties. Its chronic administration promotes antidepressant- and anxiolytic-like effects in different rodent models of depression. We have evaluated the behavioral ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pilar-Cuellar F,Castro E,Bretin S,Mocaer E,Pazos Á,Díaz Á

更新日期：2019-07-13 00:00:00

abstract：:1. There is a large body of evidence indicating that fenfluramines damage brain serotonin neurons in animals. 2. Little is known about potential adverse neuropsychiatric consequences in humans associated with use of fenfluramines that could potentially be related to serotonergic dysfunction. 3. The authors now report ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： McCann UD,Eligulashvili V,Ricaurte GA

更新日期：1998-10-01 00:00:00

abstract：:Several studies have shown anxiolytic effects of cannabinoids after systemic or central injections. The periaqueductal gray matter is a midbrain structure involved in the control of anxiety states. Intra-cerebral administration of cannabidiol, a phytocannabinoid, or anandamide, an endocannabinoid, into the dorsolatera...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Campos AC,Guimarães FS

更新日期：2009-11-13 00:00:00

abstract：OBJECTIVE:Major depressive disorder (MDD) is a ubiquitous mental illness with heterogeneous symptoms, however, the pathophysiology mechanisms are still not fully understood. Clinical and preclinical studies suggested that depression could cause disturbances in sensory perception systems, disruptions in auditory and vis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lu F,Cui Q,Huang X,Li L,Duan X,Chen H,Pang Y,He Z,Sheng W,Han S,Chen Y,Yang Y,Luo W,Yu Y,Jia X,Tang Q,Li D,Xie A,Chen H

更新日期：2020-06-08 00:00:00

abstract：:Organic cation transporter 2 (OCT2) and 3 (OCT3) are low-affinity, high-capacity transporters (uptake-2) expressed in the central nervous system (CNS) and other major organs. Proven to be essential components in the CNS functions, OCT2 and OCT3 are suggested as potential targets of antidepressant therapeutics recently...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sun S,Wang K,Lei H,Li L,Tu M,Zeng S,Zhou H,Jiang H

更新日期：2014-03-03 00:00:00

abstract：:Ibogaine (IBO) is an alkaloid with putative antiaddictive properties, alleviating opiates dependence and withdrawal. The glutamate N-methyl-D-aspartate (NMDA) receptors have been implicated in the physiological basis of drug addiction; accordingly, IBO acts as a noncompetitive NMDA antagonist. The purpose of this stud...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Leal MB,Michelin K,Souza DO,Elisabetsky E

更新日期：2003-08-01 00:00:00

abstract：:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly mea...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rothermundt M,Ohrmann P,Abel S,Siegmund A,Pedersen A,Ponath G,Suslow T,Peters M,Kaestner F,Heindel W,Arolt V,Pfleiderer B

更新日期：2007-03-30 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism (SNP) rs1344706 [A>C] within intron 2 of the zinc finger protein 804A gene (ZNF804A) is associated with schizophrenia at the genome-wide level, but its function in relation to the development of psychotic disorders, including its influence on brain morphology remains unclea...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Quidé Y,Matosin N,Atkins JR,Fitzsimmons C,Cairns MJ,Carr VJ,Australian Schizophrenia Research Bank (ASRB).,Green MJ

更新日期：2018-03-02 00:00:00

abstract：:In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. A d...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Allison AC,Cacabelos R,Lombardi VR,Alvarez XA,Vigo C

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerab...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Miyaoka T,Furuya M,Yasuda H,Hayashida M,Nishida A,Inagaki T,Horiguchi J

更新日期：2008-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced working memory deficits, synaptic loss, and amyloid β peptide aggregation into oligomers and p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Grizzell JA,Patel S,Barreto GE,Echeverria V

更新日期：2017-08-01 00:00:00

abstract：:1. Clinical response to treatment with haloperidol was studied in 20 schizophrenic inpatients with acute exacerbation (DSM-IIIR). 2. Patients were assigned to fixed doses of haloperidol (10, 20 or 30 mg/day) for three weeks. Clinical assessment was made using scales SAPS, SANS, BPRS and Simpson-Angus Scale for rating ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Palao DJ,Arauxo A,Brunet M,Marquez M,Bernardo M,Ferrer J,Gonzalez-Monclus E

更新日期：1994-01-01 00:00:00