Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects.

Abstract:

:Apomorphine HCl (Apo) (0.25, 0.5 or 0.75 mg sc), a dopamine (DA) receptor agonist, induced penile erections (PEs) (monitored by mercury strain gauges and continuous recording on paper strip charts) in 7 out of 9 normal subjects and placebo in 1 of these 9 (p less than 0.05). Apo-induced PEs recurred in each of the 6 subjects retested. Benztropine (2 mg iv) had no effect on Apo-induced penile tumescence (PT). These data suggest (a) DA mechanisms play a role in normal erectile function (b) DA-mediated PT is not modulated by cholinergic systems (c) evaluation of the erectile response to Apo may provide a simple ancillary test to the investigation of impotence and a way of identifying a subpopulation of impotent subjects with impaired DA function who may respond to long-acting DA agents (d) Apo-induced PT may provide a novel way of studying DA function in man.

authors

Lal S,Ackman D,Thavundayil JX,Kiely ME,Etienne P

doi

10.1016/0278-5846(84)90040-x

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

695-9

issue

4-6

eissn

0278-5846

issn

1878-4216

journal_volume

8

pub_type

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