Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression.

Abstract:

:Several studies have shown that olanzapine is effective in weight restoration and maintenance for patients with anorexia nervosa (AN). However, major depression is a very common comorbid psychiatric disorder associated with AN. Additional antidepressant therapy may be required for treating anorexic patients with major depression. The authors present a case of AN associated with major depression, who responded well to the combination treatment of olanzapine and mirtazapine. A 27-year-old Taiwanese woman was admitted because of severe weight loss, poor nutrition, amenorrhea, major depression, and starvation complications including hematological dyscrasis, electrolytes and endocrine imbalance, and sinus bradycardia. In additional to nutritional and medical treatments, the patient was given olanzapine 10 mg/day and mirtazapine 30 mg/day. She took the combined medications for six months. Meanwhile she received cognitive behavior therapy and family therapy. With these treatments, the patient's depression was in remission, her body weight was increased from 24 to 38 kg, and her body mass index was increased from 9.8 to 15.5. Our case suggests that the combined treatment of olanzapine and mirtazapine can be used in the treatment of AN associated with major depression.

authors

Wang TS,Chou YH,Shiah IS

doi

10.1016/j.pnpbp.2005.10.004

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

306-9

issue

2

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(05)00311-8

journal_volume

30

pub_type

杂志文章
  • SSRIs and conditioned fear.

    abstract::Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders. The precise mechanisms of the anxiolytic actions of SSRIs are unclear. We reviewed the literature related to the effects of SSRIs and the neur...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2011.09.002

    authors: Inoue T,Kitaichi Y,Koyama T

    更新日期:2011-12-01 00:00:00

  • Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls.

    abstract:OBJECTIVE:Internet gaming disorder (IGD) shares core clinical features with other addictive disorders, such as gambling disorder and substance use disorder. Designation of IGD as a formal disorder requires elucidation of its neurobiological features and comparison of these with those of other addictive disorders. The a...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.02.004

    authors: Kim H,Kim YK,Gwak AR,Lim JA,Lee JY,Jung HY,Sohn BK,Choi SW,Kim DJ,Choi JS

    更新日期:2015-07-03 00:00:00

  • The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats.

    abstract::Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders for centuries in China. Our previous studies have demonstrated that the total flavonoids (XBXT-2) isolated from the extract of XBXT reversed behavioral alterations and serotonergic dysfunctions in chr...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2008.05.005

    authors: An L,Zhang YZ,Yu NJ,Liu XM,Zhao N,Yuan L,Chen HX,Li YF

    更新日期:2008-08-01 00:00:00

  • Recent advances of induced pluripotent stem cells application in neurodegenerative diseases.

    abstract::Stem cell is defined by its ability to self-renewal and generates differentiated functional cell types, which are derived from the embryo and various sources of postnatal animal. These cells can be divided according to their potential development into totipotent, unipotent, multipotent andpluripotent. Pluripotent is c...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2019.109674

    authors: Amin N,Tan X,Ren Q,Zhu N,Botchway BOA,Hu Z,Fang M

    更新日期:2019-12-20 00:00:00

  • Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants.

    abstract:BACKGROUND:The single nucleotide polymorphism (SNP) rs1344706 [A>C] within intron 2 of the zinc finger protein 804A gene (ZNF804A) is associated with schizophrenia at the genome-wide level, but its function in relation to the development of psychotic disorders, including its influence on brain morphology remains unclea...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2017.12.007

    authors: Quidé Y,Matosin N,Atkins JR,Fitzsimmons C,Cairns MJ,Carr VJ,Australian Schizophrenia Research Bank (ASRB).,Green MJ

    更新日期:2018-03-02 00:00:00

  • Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms.

    abstract::Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confe...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.pnpbp.2017.07.017

    authors: Chye Y,Solowij N,Ganella EP,Suo C,Yücel M,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Bartholomeusz CF,Lorenzetti V

    更新日期:2017-10-03 00:00:00

  • A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease.

    abstract::Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2012.06.022

    authors: Seitz DP,Reimer CL,Siddiqui N

    更新日期:2013-12-02 00:00:00

  • Pharmacogenetics in major depression: a comprehensive meta-analysis.

    abstract::A number of candidate gene studies focused on major depression (MD) and antidepressant (AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a comprehensive meta-analysis of published candidate gene studies focused on AD efficacy in MD to evaluate the cumulative evidence. A random-e...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.pnpbp.2013.05.011

    authors: Niitsu T,Fabbri C,Bentini F,Serretti A

    更新日期:2013-08-01 00:00:00

  • No association between the neuronal pentraxin II gene polymorphism and autism.

    abstract::Autism (MIM 209850) is a neurodevelopmental disorder characterized by difficulties with verbal and non-verbal communication, impairments in reciprocal social interactions, and displays of stereotypic behaviors, interests and activities. Twin and family studies have indicated a robust role of genetic factors in the dev...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.02.016

    authors: Marui T,Koishi S,Funatogawa I,Yamamoto K,Matsumoto H,Hashimoto O,Ishijima M,Nanba E,Nishida H,Sugiyama T,Kasai K,Watanabe K,Kano Y,Kato N,Sasaki T

    更新日期:2007-05-09 00:00:00

  • Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder.

    abstract::While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, inc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110175

    authors: Joo SW,Kim H,Jo YT,Yoon W,Kim Y,Lee J

    更新日期:2020-11-12 00:00:00

  • Mental health outcomes following naltrexone implant treatment for heroin-dependence.

    abstract:BACKGROUND:Oral naltrexone is an approved treatment for opioid dependence. However, the impact of sustained release naltrexone on the mental health of treated opioid users has not been studied. AIMS:To assess if naltrexone via implant treatment was associated with any change in (i) risk, (ii) rate, and (iii) duration ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.pnpbp.2006.12.005

    authors: Ngo HT,Tait RJ,Arnold-Reed DE,Hulse GK

    更新日期:2007-04-13 00:00:00

  • Differential inhibition of neurogenesis and angiogenesis by corticosterone in rats stimulated with electroconvulsive seizures.

    abstract::Antidepressant drugs and electroconvulsive seizure (ECS)-treatment, an animal model of electroconvulsive therapy, induce neurogenesis in adult rats. Stress and high levels of corticosterone (CORT) on the contrary inhibit neurogenesis. Hippocampal neurogenesis has been described to occur in an angiogenic niche where pr...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2008.05.012

    authors: Ekstrand J,Hellsten J,Wennström M,Tingström A

    更新日期:2008-08-01 00:00:00

  • Behavioral modifications in relation to hypothyroidism and hyperthyroidism in adult rats.

    abstract::1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(89)90044-4

    authors: Fundaro A

    更新日期:1989-01-01 00:00:00

  • Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects.

    abstract::Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HM...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.07.022

    authors: Narita K,Murata T,Hamada T,Takahashi T,Kosaka H,Sudo S,Mizukami K,Yoshida H,Wada Y

    更新日期:2008-01-01 00:00:00

  • Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.

    abstract::1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA, L-glutamate, aspartate, and other dicarboxylic amino acids; ii) glycine, D-serine, D-cycloserine, and others; iii) the p...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90079-g

    authors: Lehmann J,Colpaert F,Canton H

    更新日期:1991-01-01 00:00:00

  • Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?

    abstract::Group II metabotropic glutamate receptor (mGluR2/3) agonists once showed promise as non-dopaminergic antipsychotic drugs because of their efficacy in alleviating symptoms of schizophrenia (SZ) in both animal models and human patients. However, the recent failure of Phase III clinical trials dealt a huge blow to the sc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2015.02.012

    authors: Li ML,Hu XQ,Li F,Gao WJ

    更新日期:2015-07-03 00:00:00

  • Birth months and vulnerability to juvenile delinquency.

    abstract:BACKGROUND:Birth months have been shown to affect susceptibility to schizophrenia and other mental disorders, thus this factor could also affect predisposition to delinquency through biological effects on brain development and personality and/or through relative age effects at school. This study aimed to examine the re...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.07.003

    authors: Ohtani T,Sasaki T,Kadomoto I,Kato N,Yoshinaga C

    更新日期:2008-01-01 00:00:00

  • High trait anxiety in healthy subjects is associated with low neuroendocrine activity during psychosocial stress.

    abstract::Altered stress responsiveness has been repeatedly related to mood and anxiety disorders. In a traditional view, a reduction of the stress response has been thought favorable. The goal of the present study was to verify the hypothesis that high anxiety is accompanied by enhanced hormone release during stress. Healthy s...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2004.08.005

    authors: Jezova D,Makatsori A,Duncko R,Moncek F,Jakubek M

    更新日期:2004-12-01 00:00:00

  • Regulation of beta-amyloid precursor protein and inositol 1,4,5-trisphosphate receptor gene expression during differentiation of a human neuronal cell line.

    abstract::Retinoic acid-induced differentiation of SH-SY5Y human neuroblastoma cells results in the development of extensive neurite processes as well as changes in cell body morphology toward a neuronal phenotype. The authors have examined concurrent regulation of beta-amyloid precursor protein (APP) and inositol 1,4,5-trispho...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0278-5846(02)00352-4

    authors: Murray JN,Igwe OJ

    更新日期:2003-05-01 00:00:00

  • Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices.

    abstract::The neuropeptide substance P (SP) has been suggested to be involved in several physiological and pathological conditions including learning and memory and the processing of pain. This study investigated for the first time acute effects of SP and the neurokinin-1 (NK-1) receptor antagonist L-733060 on long term potenti...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2004.11.017

    authors: Langosch JM,Kupferschmid S,Heinen M,Walden J,Herpfer I,Fiebich BL,Lieb K

    更新日期:2005-02-01 00:00:00

  • Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population.

    abstract::Autism is a complex neurodevelopmental disorder with high heritability. Previous genome-wide association studies (GWAS) demonstrated that some single-nucleotide polymorphisms (SNPs) were significantly associated with autism, while other studies focusing on these GWAS hits showed inconsistent results. Besides, the asso...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2018.12.016

    authors: Wang Z,Zhang J,Lu T,Zhang T,Jia M,Ruan Y,Zhang D,Li J,Wang L

    更新日期:2019-06-08 00:00:00

  • Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia.

    abstract:OBJECTIVE:To investigate (i) the association between four serotonergic polymorphisms (A-1438G and T102C of the 5-HT2A receptor gene, and 5-HTT VNTR and 5-HTTLPR of the 5-HT transporter gene) and schizophrenia and (ii) the potential interaction of those polymorphisms in the development of schizophrenia. SUBJECTS AND ME...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2007.01.012

    authors: Sáiz PA,García-Portilla MP,Arango C,Morales B,Alvarez V,Coto E,Fernández JM,Bascarán MT,Bousoño M,Bobes J

    更新日期:2007-04-13 00:00:00

  • P300 event-related potentials in probable dissociative generalized amnesia.

    abstract::1. To investigate whether abnormalities in objective neurophysiologic measures are observable in patients with probable dissociative generalized amnesia, the P300 and N100 event-related potentials were evaluated in six such patients in both acute stage and after recovery from amnesia. Findings were compared with those...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(99)00068-8

    authors: Fukuzako H,Fukuzaki S,Fukuzako T,Jing H,Ueyama K,Takigawa M

    更新日期:1999-11-01 00:00:00

  • Effect of dietary phenylalanine on the plasma concentrations of phenylalanine, phenylethylamine and phenylacetic acid in healthy volunteers.

    abstract::1. Phenylethylamine has been proposed as a neuromodulator in several psychiatric and other brain disorders, and its concentration and that of its major metabolite, phenylacetic acid, in plasma may prove useful as state or trait markers in diagnosis, treatment or in the elucidation of biochemical mechanisms of these di...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90051-2

    authors: Davis BA,O'Reilly RL,Placatka CL,Paterson IA,Yu PH,Durden DA

    更新日期:1991-01-01 00:00:00

  • The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders.

    abstract::1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxyphenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined. The same relationships apply fo...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(91)90025-v

    authors: Davis BA,Durden DA,O'Reilly RL

    更新日期:1991-01-01 00:00:00

  • Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory.

    abstract::The aim of the current study was to examine the existence of a cooperative interaction between the basolateral nucleus of amygdala (BLA) and the ventral tegmental area (VTA) in inhibitory avoidance task. The BLA and the VTA regions of adult male Wistar rats were simultaneously cannulated and memory consolidation was m...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2012.10.003

    authors: Nazari-Serenjeh F,Rezayof A

    更新日期:2013-01-10 00:00:00

  • Comparisons of methamphetamine psychotic and schizophrenic symptoms: a differential item functioning analysis.

    abstract::The concept of negative symptoms in methamphetamine (MA) psychosis (e.g., poverty of speech, flatten affect, and loss of drive) is still uncertain. This study aimed to use differential item functioning (DIF) statistical techniques to differentiate the severity of psychotic symptoms between MA psychotic and schizophren...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.01.014

    authors: Srisurapanont M,Arunpongpaisal S,Wada K,Marsden J,Ali R,Kongsakon R

    更新日期:2011-06-01 00:00:00

  • RBC-choline: a biological marker of the outcome of lithium prophylaxis?

    abstract::We explored whether the elevation of RBC-choline and choline ratio (RBC-choline/plasma-choline) by lithium is a specific effect of lithium, whether these choline parameters are characteristics of the individual patient, and whether they are related to prophylactic lithium response. In lithium-treated patients RBC-chol...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(87)90062-5

    authors: Haag M,Granzow L,Greil W,Haag H

    更新日期:1987-01-01 00:00:00

  • Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder.

    abstract::Post-traumatic stress disorder (PTSD) is characterized by impairments in mnestic functions, especially in the domain of episodic memory. These alterations might affect different aspects of episodic memory functioning. Here we tested PTSD patients and healthy controls (matched for age, sex and education) in a newly dev...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2017.12.014

    authors: Zlomuzica A,Woud ML,Machulska A,Kleimt K,Dietrich L,Wolf OT,Assion HJ,Huston JP,De Souza Silva MA,Dere E,Margraf J

    更新日期:2018-04-20 00:00:00

  • Effects of antidepressants on uptake and receptor systems in the brain.

    abstract::Many antidepressant drugs inhibit the neuronal uptake of norepinephrine, serotonin, epinephrine and/or dopamine. Some newer antidepressant drugs are highly selective in their ability to inhibit the uptake of one or more of these monoamines. This uptake inhibition, which would be expected to increase the synaptic conce...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/0278-5846(85)90006-5

    authors: Fuller RW,Wong DT

    更新日期:1985-01-01 00:00:00