Abstract：
:Several lines of evidence suggest that genetic factors might contribute to susceptibility to panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. In this study, 109 patients with panic disorder diagnosed according to the DSM-IV criteria, and 178 control subjects were recruited. There were no significant differences in the frequency of the genotype or allele in these two SNPs between patients and controls [132C > T in exon V: genotype, p = 1.0, allele, p = 0.59; 196G > A (val66met) in exon XIIIA: genotype, p = 0.77, allele, p = 0.78]. Furthermore, no significant associations of agoraphobia with the two SNPs were detected. This study suggests that the BDNF gene polymorphisms are not associated with panic disorder in our Japanese population.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Shimizu E,Hashimoto K,Koizumi H,Kobayashi K,Itoh K,Mitsumori M,Ohgake S,Okamura N,Koike K,Matsuzawa D,Zhang L,Kumakiri C,Nakazato M,Komatsu N,Iyo Mdoi
10.1016/j.pnpbp.2005.04.018subject
Has Abstractpub_date
2005-06-01 00:00:00pages
708-12issue
5eissn
0278-5846issn
1878-4216pii
S0278-5846(05)00137-5journal_volume
29pub_type
杂志文章abstract：:Auditory verbal hallucinations (AVHs) constitute a frequent and distressing symptom of schizophrenia, associated with physical, emotional, and cognitive challenges. Despite their clinical importance, changes in the multiple dimensions of AVHs during treatment have rarely been examined, and subjective views thereof hav...
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.07.020
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2009-04-30 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2016.08.004
更新日期：2017-01-04 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2007-05-09 00:00:00
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doi：10.1016/j.pnpbp.2007.09.023
更新日期：2008-02-15 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2019-03-08 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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doi：10.1016/j.pnpbp.2011.10.003
更新日期：2012-01-10 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(92)90076-q
更新日期：1992-03-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2017.01.011
更新日期：2017-04-03 00:00:00
