当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies.

Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies.

Abstract：

BACKGROUND:Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and depression have provided inconclusive findings. A meta-analysis was therefore performed to investigate a more reliable estimate. METHODS:This meta-analysis recruited 26 published studies which were selected by a search of electronic databases up to January 2013, including 4992 depression cases and 17,082 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR C677T polymorphism and depression susceptibility using random effect models. RESULTS:Meta-analyses results suggested that MTHFR C677T polymorphism contributed to the increased depression risk in overall populations (for T vs. C: OR=1.19, 95%CI=1.07-1.32; for TT+CT vs. CC: OR=1.15, 95%CI=1.01-1.31; for TT vs. CC: OR=1.42, 95%CI=1.16-1.75; for TT vs. CT+CC: OR=1.38, 95%CI=1.16-1.63). Subgroup analysis by ethnicity indicated an association in Asian populations (for T vs. C: OR=1.36, 95%CI=1.11-1.66; for TT+CT vs. CC: OR=1.32, 95%CI=1.03-1.69; for TT vs. CC: OR=1.88, 95%CI=1.26-2.79; for TT vs. CT+CC: OR=1.76, 95%CI=1.30-2.38); and a marginal association in White populations (for TT vs. CT+CC: OR=1.15, 95%CI=1.01-1.31). However, the association between the MTHFR C677T polymorphism and depression was not observed in the elderly. CONCLUSION:The MTHFR C677T polymorphism was associated with an increased risk of depression, especially in Asian populations. However, there was no evidence indicating a correlation in the elderly.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Wu YL,Ding XX,Sun YH,Yang HY,Chen J,Zhao X,Jiang YH,Lv XL,Wu ZQ

doi

10.1016/j.pnpbp.2013.06.015

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

78-85

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(13)00126-7

journal_volume

46

pub_type

杂志文章,meta分析

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Sputum interleukin-6, tumor necrosis factor-α and Salivary cortisol as new biomarkers of depression in lung cancer patients.

    abstract：:Depression is common among lung cancer patients. Increasing evidence has suggested that hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines may play a key role in the pathophysiology of depression as well as cancer. This pilot study investigated the efficacy of sputum interleukin (IL)-6, tumor nec...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.08.004

    authors： Du YJ,Zhang HY,Li B,Wu X,Lv YB,Jin HL,Cao YX,Sun J,Luo QL,Gong WY,Liu BJ,Wu JF,Shi SX,Dong JC

    更新日期：2013-12-02 00:00:00

  • A review of pharmacological agents for self-injurious behavior.

    abstract：:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression ar...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(90)90093-v

    authors： Luchins DJ

    更新日期：1990-01-01 00:00:00

  • D1/D2 actions of dopaminergic drugs studied with [14C]-2-deoxyglucose autoradiography.

    abstract：:1. To define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of L-dopa and selective D1 and D2 agonists on RCGU in rats with unilateral 6-OHDA substantia nigra lesions. 2. Systemic administration of L-dopa markedly increased RCGU in the EP and SNr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(95)00132-f

    authors： Trugman JM

    更新日期：1995-09-01 00:00:00

  • Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population.

    abstract：OBJECTIVE:Genetic factors play a critical role in the etiology of bipolar disorder (BPAD). Previous studies suggested an association between thyroid dysfunction and BPAD. We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated w...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.05.003

    authors： He B,Li J,Wang G,Ju W,Lu Y,Shi Y,He L,Zhong N

    更新日期：2009-08-31 00:00:00

  • The effect of ritanserin on treatment-resistant neuroleptic induced akathisia: case reports.

    abstract：:1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90076-q

    authors： Miller CH,Hummer M,Pycha R,Fleischhacker WW

    更新日期：1992-03-01 00:00:00

  • Transcranial direct current stimulation can enhance working memory in Huntington's disease.

    abstract：:Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in working memory (WM) can be apparent early in the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2017.04.002

    authors： Eddy CM,Shapiro K,Clouter A,Hansen PC,Rickards HE

    更新日期：2017-07-03 00:00:00

  • Clinical studies of 5-HT function using i.v. L-tryptophan.

    abstract：:1. Preclinical studies reveal that long-term treatment with antidepressant drugs induces significant changes in serotonergic (5-HT) receptor sensitivity. Similarly, clinical studies suggest that brain 5-HT function is abnormal in depression. Of the available methodologies for conducting such clinical studies, the phar...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(90)90002-x

    authors： Price LH,Charney DS,Delgado PL,Goodman WK,Krystal JH,Woods SW,Heninger GR

    更新日期：1990-01-01 00:00:00

  • The use of the zebrafish model in stress research.

    abstract：:The study of the causes and mechanisms underlying psychiatric disorders requires the use of non-human models for the test of scientific hypotheses as well as for use in pre-clinical drug screening and discovery. This review argues in favor of the use of zebrafish as a novel animal model to study the impact of early (s...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.10.010

    authors： Steenbergen PJ,Richardson MK,Champagne DL

    更新日期：2011-08-01 00:00:00

  • Prefrontal brain metabolites in short-term weight-recovered adolescent anorexia nervosa patients.

    abstract：:Various neuroimaging techniques have revealed morphological and functional alterations in anorexia nervosa (AN), although few spectroscopic magnetic resonance studies have examined short-term weight-recovered AN patients. Subjects were 32 female adolescent patients (between 13 and 18 years old) seen consecutively in o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.05.020

    authors： Castro-Fornieles J,Garcia AI,Lazaro L,Andrés-Perpiñá S,Falcón C,Plana MT,Bargallo N

    更新日期：2010-08-16 00:00:00

  • Cross-species behavioural genetics: A starting point for unravelling the neurobiology of human psychiatric disorders.

    abstract：:Identifying the genetic and neurobiological mechanisms underlying certain behavioural traits is an important strategy to understand the aetiology of various psychiatric disorders and to find potential new treatment possibilities. It has proven a great challenge to develop paradigms that allow translational research fo...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.10.003

    authors： de Mooij-van Malsen AJ,Vinkers CH,Peterse DP,Olivier B,Kas MJ

    更新日期：2011-08-01 00:00:00

  • Role of interleukin 8 in depression and other psychiatric disorders.

    abstract：:Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloods...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2020.110173

    authors： Tsai SJ

    更新日期：2021-03-02 00:00:00

  • Abnormal effective fronto-limbic connectivity during emotion processing in schizophrenia.

    abstract：BACKGROUND:Schizophrenia is associated with core emotional dysfunctions. At the neural level, functional neuro-imaging studies have highlighted fronto-limbic alterations during emotion processing in schizophrenia, as well as impaired connectivity between the amygdala and the prefrontal cortex. However, the direction of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2016.08.004

    authors： Potvin S,Lungu O,Tikàsz A,Mendrek A

    更新日期：2017-01-04 00:00:00

  • Pain and consciousness.

    abstract：:The aversive experience we call "pain" results from the coordinated activation of multiple brain areas, commonly described as a "pain matrix". This is not a fixed arrangement of structures but rather a fluid system composed of several interacting networks: A 'nociceptive matrix' includes regions receiving input from a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.10.007

    authors： Garcia-Larrea L,Bastuji H

    更新日期：2018-12-20 00:00:00

  • Believing is achieving - On the role of treatment expectation in neurofeedback applications.

    abstract：:In neurofeedback applications, neural activity is recorded, processed in real-time and fed back to the user in order to facilitate self-regulation of the putative neural mechanisms that underlie cognition and behavior. Numerous studies suggest that neurofeedback interventions are an efficacious treatment particularly ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110129

    authors： Schönenberg M,Weingärtner AL,Weimer K,Scheeff J

    更新日期：2021-03-08 00:00:00

  • Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.

    abstract：:Adolescence is a developmental period marked by robust neural alterations and heightened vulnerability to stress, a factor that is highly associated with increased risk for emotional processing deficits, such as anxiety. Stress-induced upregulation of the dynorphin/kappa opioid receptor (DYN/KOP) system is thought to,...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109812

    authors： Varlinskaya EI,Johnson JM,Przybysz KR,Deak T,Diaz MR

    更新日期：2020-03-02 00:00:00

  • Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment.

    abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.05.007

    authors： Knezevic D,Mizrahi R

    更新日期：2018-01-03 00:00:00

  • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA.

    abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.002

    authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

    更新日期：2004-03-01 00:00:00

  • Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression.

    abstract：BACKGROUND:Abnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; however, the underlying mechanisms remain uncertain. This study characterized plasma levels and affinities of OT- and VP-reactive autoantibodies (a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.09.021

    authors： Garcia FD,Coquerel Q,Kiive E,Déchelotte P,Harro J,Fetissov SO

    更新日期：2011-01-15 00:00:00

  • Regulation of dopamine release and metabolism in rat striatum in vivo: effects of dopamine receptor antagonists.

    abstract：:1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol (0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00267-7

    authors： Rayevsky KS,Gainetdinov RR,Grekhova TV,Sotnikova TD

    更新日期：1995-12-01 00:00:00

  • A review of the neuropharmacological properties of khat.

    abstract：BACKGROUND:The psychostimulant khat (Catha edulis Forsk), is a herbal drug cultivated and chewed as a recreational and socializing drug in East Africa and the Arabian Peninsula for centuries. Due to increasing air transportation and the loosening of customs restrictions, it is now readily available in the Western Count...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2007.12.033

    authors： Feyissa AM,Kelly JP

    更新日期：2008-07-01 00:00:00

  • Capillary electrophoresis mass spectrometry as a potential tool to detect lithium-induced nephropathy: Preliminary results.

    abstract：:Lithium remains the treatment of choice for many patients suffering from bipolar disorder. However, long-term treatment with lithium carries the potential to cause renal and thyroid dysfunction. Lithium-induced nephropathies are characterised by deterioration of urinary concentrating ability as well as, less frequentl...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.11.015

    authors： Raedler TJ,Wittke S,Jahn H,Koessler A,Mischak H,Wiedemann K

    更新日期：2008-04-01 00:00:00

  • Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder.

    abstract：:While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, inc...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110175

    authors： Joo SW,Kim H,Jo YT,Yoon W,Kim Y,Lee J

    更新日期：2020-11-12 00:00:00

  • Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects.

    abstract：:Apomorphine HCl (Apo) (0.25, 0.5 or 0.75 mg sc), a dopamine (DA) receptor agonist, induced penile erections (PEs) (monitored by mercury strain gauges and continuous recording on paper strip charts) in 7 out of 9 normal subjects and placebo in 1 of these 9 (p less than 0.05). Apo-induced PEs recurred in each of the 6 s...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(84)90040-x

    authors： Lal S,Ackman D,Thavundayil JX,Kiely ME,Etienne P

    更新日期：1984-01-01 00:00:00

  • Pharmacological evidence of the stimulation of central alpha-adrenergic receptors.

    abstract：:We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90105-7

    authors： Simon P,Chermat R,Puech AJ

    更新日期：1983-01-01 00:00:00

  • The effects of the co-administration of the α₁-adrenoreceptor antagonist prazosin on the anxiolytic effect of citalopram in conditioned fear stress in the rat.

    abstract：:Several studies have shown that the α₁-adrenoreceptor is involved in controlling extracellular serotonin levels. The administration of the α₁-adrenoreceptor antagonist prazosin was shown to decrease extracellular serotonin levels in the hippocampus, the prefrontal cortex and the raphe nucleus, while the administration...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.05.017

    authors： Takamura N,Masuda T,Inoue T,Nakagawa S,Koyama T

    更新日期：2012-10-01 00:00:00

  • Suriclone: a new anxiolytic drug.

    abstract：:Suriclone, a new psychotherapeutic agent chemically unrelated to benzodiazepines or phenothiazines was assessed in a single-blind dose-ranging study to determine its efficacy and safety in out-patients with generalized anxiety disorder. Suriclone was an effective anxiolytic drug at a dose range between 1.2 mg. and 3.6...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(83)90071-4

    authors： Lapierre YD,Oyewumi KL

    更新日期：1983-01-01 00:00:00

  • The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro.

    abstract：RATIONALE:The endogenous alkaloid harmane is enriched in plasma of patients with neurodegenerative or addictive disorders. As harmane affects neuronal activity and viability and because both parameters are strongly influenced by intracellular pH (pH(i)), we tested whether effects of harmane are correlated with altered ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.08.043

    authors： Bonnet U,Scherbaum N,Wiemann M

    更新日期：2008-02-15 00:00:00

  • Increased frequency of T cells expressing IL-10 in Alzheimer disease but not in late-onset depression patients.

    abstract：:Higher risk of dementia is expected for patients with late onset depression (LOD) history. The IL-10 polymorphisms are associated with Alzheimer disease (AD). On the other hand, there is no study associating IL-10 polymorphisms to LOD. This study aimed to investigate the -1082G/A polymorphism association in LOD, AD pa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.07.021

    authors： Torres KC,Araújo Pereira P,Lima GS,Bozzi IC,Rezende VB,Bicalho MA,Moraes EN,Miranda DM,Romano-Silva MA

    更新日期：2013-12-02 00:00:00

  • The relationship between prolactin response and clinical efficacy of risperidone in acute psychotic inpatients.

    abstract：:Hyperprolactinemia can be induced by dopamine D2 receptor-binding drugs such as antipsychotic drugs. The author investigated the relationship between changes in prolactin (PRL) and clinical efficacy of risperidone. In this study, 27 acute psychotic inpatients completed a 12-week trial of risperidone. At baseline and a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.11.037

    authors： Lee BH,Kim YK

    更新日期：2006-06-01 00:00:00

  • Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches.

    abstract：:Neuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be critical for the progression of those disorders, which are based on genetic and epigenetic mechanisms as well as on extrinsic factors. We review here commo...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.04.033

    authors： Corrêa-Velloso JC,Gonçalves MC,Naaldijk Y,Oliveira-Giacomelli Á,Pillat MM,Ulrich H

    更新日期：2018-01-03 00:00:00