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Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke.

Abstract：

:Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Walker-Batson D,Mehta J,Smith P,Johnson M

doi

10.1016/j.pnpbp.2015.04.002

subject

Has Abstract

pub_date

2016-01-04 00:00:00

pages

225-30

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(15)00068-8

journal_volume

64

pub_type

杂志文章,评审

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