当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Effects of lithium carbonate on reproductive hormones in healthy men: relationship with body weight regulation--a pilot study.

Effects of lithium carbonate on reproductive hormones in healthy men: relationship with body weight regulation--a pilot study.

Abstract：

:1. To test the hypothesis that lithium-induced body weight gain is related to an unbalance in the reproductive hormones, lithium carbonate (900 mg/day) or placebo was administered to healthy men for 1 month. 2. Body weight, skin folds and the serum levels of thyrotropic hormone, tetraiodothyroxine, prolactin, follicle-stimulating hormone, luteinizing hormone, testosterone (T5), dehydroepiandrosterone sulfate (DHEAS), estradiol (E2), cortisol, the ratios E2/T5 and T5/DHEA-S, and blood lipids were evaluated before and during treatment. 3. Body weight, skin folds, hormones and lipids serum levels were not significantly affected by the treatment with Li. These results agree with previous reports of lack of effects of 1 month-Li administration on appetite and body weight in normal male subjects (Chen et al., 1992), and question the appropriateness of studying Li-induced obesity in healthy volunteers, given the short-term administration and low doses of Li that must be used.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Baptista T,Alastre T,Contreras Q,Martinez JL,Araujo de Baptista E,Burguera JL,de Burguera M,Hernández L

doi

10.1016/s0278-5846(97)00090-0

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

937-50

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278584697000900

journal_volume

21

pub_type

临床试验,杂志文章

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