当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.

A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.

Abstract：

:Even though 85% of adults drink caffeinated beverages daily, very limited studies on plasma caffeine concentration in the US population have been published. Smoking induces cytochrome P450 1A2 (CYP1A2), which is the main enzyme involved in caffeine metabolism. The current naturalistic pilot study explores plasma caffeine concentrations in a US sample, and presents a mathematical model of the relationship between caffeine intake and plasma concentrations for smokers and nonsmokers. Caffeine intake and average plasma caffeine concentrations from morning (7:30-9:30 a.m.) and afternoon (2:00-4:00 p.m.) samples were studied in 69 volunteers (21 smokers and 48 nonsmokers). The mean caffeine intake obtained from caffeinated beverages was 3.02 mg/kg/day, which is similar to the intake in the US population. Almost all subjects in the present sample (99%; 95% confidence interval [CI]: 96-100) had detectable plasma caffeine concentrations. Smokers had significantly higher caffeine intake than nonsmokers. The ratio of concentration/dose of caffeine from caffeinated beverages was approximately four-fold higher in nonsmokers (1.33 kgxday/l) than in smokers (0.29 kgxday/l). According to the model, the median plasma caffeine concentration was two- to three-fold higher in nonsmokers for each level of caffeine intake. Our model improves our understanding of the interactions between caffeine and smoking. Additional studies are needed to replicate the model. This model may help epidemiologists to correct for the effects of smoking on caffeine intake and pharmacologists to screen for the activity of CYP1A2.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

de Leon J,Diaz FJ,Rogers T,Browne D,Dinsmore L,Ghosheh OH,Dwoskin LP,Crooks PA

doi

10.1016/s0278-5846(02)00348-2

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

165-71

issue

1

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(02)00348-2

journal_volume

27

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Aripiprazole augmentation in the management of residual symptoms in clozapine-treated outpatients with chronic schizophrenia: An open-label pilot study.

    abstract：OBJECTIVE:The aim of this study was to investigate whether augmentation of clozapine with aripiprazole improves clinically significant residual symptoms in stabilized outpatients with chronic schizophrenia. METHODS:Twenty seven stabilized outpatients meeting criteria for chronic schizophrenia, who had residual symptom...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2006.09.015

    authors： Mitsonis CI,Dimopoulos NP,Mitropoulos PA,Kararizou EG,Katsa AN,Tsakiris FE,Katsanou MN

    更新日期：2007-03-30 00:00:00

  • A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.

    abstract：:Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic var...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.08.010

    authors： Masui T,Hashimoto R,Kusumi I,Suzuki K,Tanaka T,Nakagawa S,Suzuki T,Iwata N,Ozaki N,Kato T,Takeda M,Kunugi H,Koyama T

    更新日期：2008-01-01 00:00:00

  • Potentiation of synaptic transmission by (S)-3,5-dihydroxy phenylglycine in the rat dentate gyrus in vitro: a role for voltage dependent calcium channels and protein kinase C.

    abstract：:1. The authors have previously shown that direct activation of metabotropic glutamate receptors (mGluRs) by (S)-3,5-dihydroxyphenylglycine ((S)-DHPG) can induce a long-lasting potentiation of synaptic transmission in the rat dentate gyrus in vitro. Here the authors provide further characterisation of this agonist-indu...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(98)00095-5

    authors： O'Leary DM,O'Connor JJ

    更新日期：1999-01-01 00:00:00

  • IRE1α pathway of endoplasmic reticulum stress induces neuronal apoptosis in the locus coeruleus of rats under single prolonged stress.

    abstract：:Our previous studies have shown evidence of endoplasmic reticulum (ER) stress-induced apoptosis in the hippocampus and mPFC in an animal model of post- traumatic stress disorder (PTSD). Inositol-requiring enzyme 1α (IRE1α) and its downstream molecule X-box binding protein 1 (XBP1) play key roles in the ER-related apop...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2016.03.008

    authors： Zhao W,Han F,Shi Y

    更新日期：2016-08-01 00:00:00

  • D1/D2 actions of dopaminergic drugs studied with [14C]-2-deoxyglucose autoradiography.

    abstract：:1. To define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of L-dopa and selective D1 and D2 agonists on RCGU in rats with unilateral 6-OHDA substantia nigra lesions. 2. Systemic administration of L-dopa markedly increased RCGU in the EP and SNr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(95)00132-f

    authors： Trugman JM

    更新日期：1995-09-01 00:00:00

  • Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder.

    abstract：OBJECTIVE:Bipolar disorder is associated with a high risk of suicide. Many clinical characteristics and, recently, biomarkers have been studied with the aim to find useful predictors of suicidality. The role of serum lipids has also been explored albeit with conflicting results; however, few studies have been focused o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.12.009

    authors： D'Ambrosio V,Salvi V,Bogetto F,Maina G

    更新日期：2012-04-27 00:00:00

  • Association of estrogen receptor genes and schizophrenia: a preliminary study.

    abstract：:Gender differences in various clinical features of schizophrenia have been noted and estrogen has been regarded to play important roles. A few previous studies on the association between estrogen receptor (ER) genotypes and schizophrenia focused mainly on ER α gene but failed to report consistent results. The present ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.09.012

    authors： Min JA,Kim JJ,Pae CU,Kim KH,Lee CU,Lee C,Paik IH

    更新日期：2012-01-10 00:00:00

  • Of mice and men (and women and children): scientific and ethical implications of animal models.

    abstract：:1. Animal models of human behavior and disease are commonly used and have contributed significantly to progress in understanding the physiological mechanisms of both normal function and disease, and in the development of effective therapies. 2. Little attention has been given, however, to the scientific and ethical im...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(00)00139-1

    authors： Bird SJ,Parlee MB

    更新日期：2000-11-01 00:00:00

  • The role of altered brain structural connectivity in resilience, vulnerability, and disease expression to schizophrenia.

    abstract：BACKGROUND:Schizophrenia (SCZ) is a highly heritable disorder associated with brain connectivity changes. Although the mechanism of disease expression and vulnerability of SCZ have been reported by previous studies, the mechanism of resilience to SCZ based on the brain structural connectivity is poorly understood. The ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.109917

    authors： Wei Q,Zhao L,Zou Y,Wang J,Qiu Y,Niu M,Kang Z,Liu X,Tang Y,Li C,Zhang J,Fan X,Huang R,Han Z

    更新日期：2020-07-13 00:00:00

  • Sensitization-dependent nicotine place preference in the adult zebrafish.

    abstract：:Sensitization of motor activity is a behavioural test to evaluate the effects of psychostimulants. Conditioned place preference (CPP) is an associative learning procedure to examine the rewarding properties of drugs. We aimed to assess whether motor sensitization to drugs of abuse can make zebrafish more vulnerable to...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.02.018

    authors： Pisera-Fuster A,Rocco L,Faillace MP,Bernabeu R

    更新日期：2019-06-08 00:00:00

  • Transcranial direct current stimulation can enhance working memory in Huntington's disease.

    abstract：:Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in working memory (WM) can be apparent early in the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2017.04.002

    authors： Eddy CM,Shapiro K,Clouter A,Hansen PC,Rickards HE

    更新日期：2017-07-03 00:00:00

  • Interactions between specific parameters of MDMA use and cognitive and psychopathological measures.

    abstract：:The aim of the present study was to investigate the relevance of different parameters of 3,4-methylenedioxymethamphetamine (MDMA) use, including age of first use, cumulative lifetime dose and highest daily dose for predicting cognitive performance and self-reported psychopathology. Moreover, interactions between those...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2014.12.004

    authors： Wagner D,Adolph S,Koester P,Becker B,Gouzoulis-Mayfrank E,Daumann J

    更新日期：2015-04-03 00:00:00

  • Diazepam fails to alter anxiety-like responses but affects motor function in a white-black test paradigm in larval zebrafish (Danio rerio).

    abstract：:The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.01.012

    authors： Zahid H,Tsang B,Ahmed H,Lee RCY,Tran S,Gerlai R

    更新日期：2018-04-20 00:00:00

  • 5-HT2C receptors in psychiatric disorders: A review.

    abstract：:5-HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post-transcriptional editing could be involved in the pathophysiology of psychiatric disorders through impairment in G-protein interactions. Mor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.12.006

    authors： Chagraoui A,Thibaut F,Skiba M,Thuillez C,Bourin M

    更新日期：2016-04-03 00:00:00

  • Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.

    abstract：:Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool befor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90191-5

    authors： Marcy R,Quermonne MA,Raoul J,Nammathao B,Smida A

    更新日期：1985-01-01 00:00:00

  • Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association.

    abstract：:The aim of the present study was to develop an animal model for the study of depressive symptoms associated with Parkinson's disease (PD). Mice treated intraperitoneally with reserpine (RES), 2.0 and 1.0 mg/kg, or its vehicle (VEHIC) were submitted to the sucrose solution (2%) consumption test (a model employed to mim...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00333-5

    authors： Skalisz LL,Beijamini V,Joca SL,Vital MA,Da Cunha C,Andreatini R

    更新日期：2002-06-01 00:00:00

  • Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography.

    abstract：:Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with si...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.06.001

    authors： Kivisaari R,Lehtinen R,Autti T,Puuskari V,Jokela O,Ahveninen J,Rapeli P,Kähkönen S

    更新日期：2007-10-01 00:00:00

  • Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.

    abstract：OBJECTIVE:To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable risk. MATRIAL AND METHODS:In a high-risk study, 234 healthy monozygotic ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.10.007

    authors： Vinberg M,Miskowiak K,Kessing LV

    更新日期：2014-01-03 00:00:00

  • Protein kinase C, learning and memory: a circular determinism between physiology and behaviour.

    abstract：:1. In vertebrates as in invertebrates, protein kinase C appears to have a key role in learning and memory, probably given its involvement in synaptic plasticity. 2. Hippocampal PKC in mammalians is activated by learning in a large variety of memory tasks. However, the kind of information processed, the type of task, a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(97)00015-8

    authors： Noguès X

    更新日期：1997-04-01 00:00:00

  • Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment.

    abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.05.007

    authors： Knezevic D,Mizrahi R

    更新日期：2018-01-03 00:00:00

  • Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone.

    abstract：:1. The authors studied the correlations between plasma concentrations of trazodone and mCPP at steady state and those after an initial dose of trazodone. 2. Fifteen depressed patients received trazodone 150 mg at bedtime for 3 weeks, and blood samplings were taken 12 h after the initial dose and 12 h after the last do...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(96)00140-6

    authors： Otani K,Mihara K,Yasui N,Ishida M,Kondo T,Tokinaga N,Ohkubo T,Osanai T,Sugawara K,Kaneko S

    更新日期：1997-01-01 00:00:00

  • The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat.

    abstract：:We have examined the effects of postnatal handling of rat pups from Days 1 to 21 on the development of the intracellular, glucocorticoid receptor in the hippocampus, and pituitary transcortin, and corticoid binding globulin in plasma. All animals were sacrificed 10-14h following adrenalectomy and the in vitro receptor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90050-8

    authors： Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Sapolsky RM

    更新日期：1985-01-01 00:00:00

  • The mouse light-dark paradigm: a review.

    abstract：:1. The light/dark paradigm is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behaviour of the animals, applying mild stressors i.e. novel environment and light. The test apparatus consists of a small dark secure compartment (one third) and a large illuminated a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(00)00151-2

    authors： Hascoët M,Bourin M,Nic Dhonnchadha BA

    更新日期：2001-01-01 00:00:00

  • Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.

    abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.010

    authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

    更新日期：2019-03-08 00:00:00

  • Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains.

    abstract：:The use of animal models (particularly rats) in research for developing drugs for central nervous system diseases is well validated. However a range of strains are often utilised in these models. The Lister-Hooded (LH) strain is beginning to be increasingly used in preclinical investigations. Thus, the objective of th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.08.004

    authors： McDermott C,Kelly JP

    更新日期：2008-12-12 00:00:00

  • Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders.

    abstract：:Adverse childhood experiences (ACE) can possibly permanently alter the stress response system, affect the glutamatergic system and influence hippocampal volume in mood disorders. The aim of the study is to investigate the association between glutamate levels in the hippocampus, measured through single proton magnetic ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2016.07.007

    authors： Poletti S,Locatelli C,Falini A,Colombo C,Benedetti F

    更新日期：2016-11-03 00:00:00

  • Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder.

    abstract：:While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, inc...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110175

    authors： Joo SW,Kim H,Jo YT,Yoon W,Kim Y,Lee J

    更新日期：2020-11-12 00:00:00

  • Slow magnetic stimulation of prefrontal cortex in depression and schizophrenia.

    abstract：:1. The authors used transcranial magnetic stimulation (TMS) of pre-frontal cortex to study mood changes in 10 depressed patients and 10 schizophrenic patients. 2. A slow rate of stimuli was used, one per 30 seconds; maximal intensity of about 2 Tesla was given for 30 stimuli, 15 on each side of the brain. 3. No side e...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(96)00161-3

    authors： Geller V,Grisaru N,Abarbanel JM,Lemberg T,Belmaker RH

    更新日期：1997-01-01 00:00:00

  • Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.

    abstract：:1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(97)00042-0

    authors： Walden J,von Wegerer J,Winter U,Berger M,Grunze H

    更新日期：1997-05-01 00:00:00

  • Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats.

    abstract：:Heroin addicts can benefit from methadone substitution therapy. However, little is known about the significance of pre-exposure to opioids for psychoactive effects of methadone. We modeled some behavioral and neurobiological aspects of the opioid abuse-related phenomena in Sprague-Dawley rats, using morphine (10 mg/kg...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.05.015

    authors： Taracha E,Chrapusta SJ,Lehner M,Skórzewska A,Płaźnik A

    更新日期：2009-08-31 00:00:00