abstract：:Cancer immunotherapy using tumor-selective, oncolytic viruses is an emerging therapeutic option for solid and hematologic malignancies. A considerable variety of viruses ranging from small picornaviruses to large poxviruses are currently being investigated as potential candidates. In the early days of virotherapy, non...

journal_title：Cytokine & growth factor reviews

authors： Leber MF,Neault S,Jirovec E,Barkley R,Said A,Bell JC,Ungerechts G

更新日期：2020-12-01 00:00:00

abstract：:The main contribution of this article is to report general statistics about COVID-19 in Brazil, based on analysis of accumulated series of confirmed cases, deaths and lethality rates, in addition to presenting graphs of moving averages for states and municipalities. The data show that the pandemic in Brazil has grown ...

journal_title：Cytokine & growth factor reviews

authors： Marinho PRD,Cordeiro GM,Coelho HFC,Brandão SCS

更新日期：2020-11-05 00:00:00

abstract：:Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The a...

journal_title：Cytokine & growth factor reviews

authors： Paz S,Ritchie A,Mauer C,Caputi M

更新日期：2020-11-02 00:00:00

abstract：:Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...

journal_title：Cytokine & growth factor reviews

authors： Fourie C,Shridas P,Davis T,de Villiers WJS,Engelbrecht AM

更新日期：2020-10-27 00:00:00

abstract：:Pancreatic cancer is a lethal disease with limited treatment options for cure. A high degree of intrinsic and acquired therapeutic resistance may result from cellular alterations in genes and proteins involved in drug transportation and metabolism, or from the influences of cancer microenvironment. Mechanistic basis f...

journal_title：Cytokine & growth factor reviews

authors： Xie VK,He J,Xie K

更新日期：2020-10-01 00:00:00

abstract：:Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ f...

journal_title：Cytokine & growth factor reviews

authors： Rani A,Chin C,Bremner R,Mohanakumar T,Angara S

更新日期：2020-08-30 00:00:00

abstract：:The coronavirus disease 19 (COVID-19) outbreak caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) had turned out to be highly pathogenic and transmittable. Researchers throughout the globe are still struggling to understand this strain's aggressiveness in search of putative therapies for its contro...

journal_title：Cytokine & growth factor reviews

authors： Rana AK,Rahmatkar SN,Kumar A,Singh D

更新日期：2020-08-25 00:00:00

abstract：:The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of older age and with medical comorbidities like cancer and d...

journal_title：Cytokine & growth factor reviews

authors： Dariya B,Nagaraju GP

更新日期：2020-06-01 00:00:00

abstract：:Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...

journal_title：Cytokine & growth factor reviews

authors： Sun X,Wang T,Cai D,Hu Z,Chen J,Liao H,Zhi L,Wei H,Zhang Z,Qiu Y,Wang J,Wang A

更新日期：2020-06-01 00:00:00

abstract：:Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. The...

journal_title：Cytokine & growth factor reviews

authors： Sluzalska KD,Slawski J,Sochacka M,Lampart A,Otlewski J,Zakrzewska M

更新日期：2020-05-18 00:00:00

abstract：:Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to ...

journal_title：Cytokine & growth factor reviews

authors： Jere SW,Houreld NN,Abrahamse H

更新日期：2019-12-01 00:00:00

abstract：:A tumor is defined as a group of cancer cells and 'surrounding' stromal bio-entities. Alongside the extracellular matrix (ECM) in the tumor microenvironment (TME), the stromal cells play key roles in cancer affliction and progression. Carcinoma-associated fibroblasts (CAFs) in the area of the tumor, whether activated ...

journal_title：Cytokine & growth factor reviews

authors： Jafari B,Hamzeh-Mivehroud M,Morris MB,Dastmalchi S

更新日期：2019-04-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and impaired quality of life and no curative treatments exist. Increasing evidence indicates that low-grade inflammation plays a pivotal role in the onset and progression of OA. In this review, we summarize emerging findings on the...

journal_title：Cytokine & growth factor reviews

authors： Xie J,Huang Z,Yu X,Zhou L,Pei F

更新日期：2019-04-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a known target in cancer therapy and targeting the receptor has proven to be extremely successful in treating cancers that are dependent on EGFR signaling. To that effect, targeted therapies to EGFR such as Cetuximab, Panitumumab-monoclonal antibodies and Gefitinib, Erlotinib...

journal_title：Cytokine & growth factor reviews

authors： Ray K,Ujvari B,Ramana V,Donald J

更新日期：2018-06-01 00:00:00

abstract：:The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...

journal_title：Cytokine & growth factor reviews

authors： Radetskyy R,Daher A,Gatignol A

更新日期：2018-04-01 00:00:00

abstract：:Inflammation and angiogenesis are two interdependent processes underlying pathogenesis of cardiovascular disorders. The initiation and progression of atherosclerosis strongly depends on specific patterns of cytokine expression. In this review, we analyze correlation between expression of two members of the cytokine fa...

journal_title：Cytokine & growth factor reviews

authors： Skoda M,Stangret A,Szukiewicz D

更新日期：2018-02-01 00:00:00

abstract：:Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...

journal_title：Cytokine & growth factor reviews

authors： Jenkins LM,Horst B,Lancaster CL,Mythreye K

更新日期：2018-02-01 00:00:00

abstract：:MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenil...

journal_title：Cytokine & growth factor reviews

authors： Cirillo F,Lazzeroni P,Catellani C,Sartori C,Amarri S,Street ME

更新日期：2018-02-01 00:00:00

abstract：:Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...

journal_title：Cytokine & growth factor reviews

authors： Naseem S,Hussain T,Manzoor S

更新日期：2018-02-01 00:00:00

abstract：:Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...

journal_title：Cytokine & growth factor reviews

authors： Seliger B

更新日期：2017-08-01 00:00:00

abstract：:Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. W...

journal_title：Cytokine & growth factor reviews

authors： Tian H,Zhao J,Brochmann EJ,Wang JC,Murray SS

更新日期：2017-04-01 00:00:00

abstract：:S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...

journal_title：Cytokine & growth factor reviews

authors： D'Amico F,Skarmoutsou E,Granata M,Trovato C,Rossi GA,Mazzarino MC

更新日期：2016-12-01 00:00:00

abstract：:Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed...

journal_title：Cytokine & growth factor reviews

authors： Negahdaripour M,Nezafat N,Ghasemi Y

更新日期：2016-12-01 00:00:00

abstract：:The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...

journal_title：Cytokine & growth factor reviews

authors： Monestier O,Blanquet V

更新日期：2016-12-01 00:00:00

abstract：:Fortepren(®), a product of the phosphorylation of polyprenols from fir needles (with sodium polyprenyl phosphate being the main active ingredient), belongs to the class of antiviral drugs with immunomodulating activity. Fortepren(®) may be used as the drug of choice in the treatment of herpes diseases. It was shown th...

journal_title：Cytokine & growth factor reviews

authors： Pronin AV,Narovlyansky AN,Shulzhenko AE,Sanin AV,Sedov AM

更新日期：2016-08-01 00:00:00

abstract：:Since its discovery, SUMOylation has emerged as a key post-translational modification involved in the regulation of host-virus interactions. SUMOylation has been associated with the replication of a large number of viruses, either through the direct modification of viral proteins or through the modulation of cellular ...

journal_title：Cytokine & growth factor reviews

authors： Hannoun Z,Maarifi G,Chelbi-Alix MK

更新日期：2016-06-01 00:00:00

abstract：:Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respect...

journal_title：Cytokine & growth factor reviews

authors： Hermanns HM

更新日期：2015-10-01 00:00:00

abstract：:Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...

journal_title：Cytokine & growth factor reviews

authors： Egwuagu CE,Yu CR,Sun L,Wang R

更新日期：2015-10-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of this cytokine family play key, non-redundant role...

journal_title：Cytokine & growth factor reviews

authors： Pasquin S,Sharma M,Gauchat JF

更新日期：2015-10-01 00:00:00

abstract：:In this short review, we summarize how insights into the structure and dynamics of interferon-receptor complex assembly and activation guided the design of a novel class of engineered type I interferons that combine a largely lost potency on non-targeted cells with high activity on targeted cells. These novel interfer...

journal_title：Cytokine & growth factor reviews

authors： Uzé G,Tavernier J

更新日期：2015-04-01 00:00:00

abstract：:The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...

journal_title：Cytokine & growth factor reviews

authors： Antonelli G,Scagnolari C,Moschella F,Proietti E

更新日期：2015-04-01 00:00:00

abstract：:Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferatio...

journal_title：Cytokine & growth factor reviews

authors： Avau A,Put K,Wouters CH,Matthys P

更新日期：2015-02-01 00:00:00

abstract：:Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...

journal_title：Cytokine & growth factor reviews

authors： Shu C,Li X,Li P

更新日期：2014-12-01 00:00:00

abstract：:The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the...

journal_title：Cytokine & growth factor reviews

authors： Tu E,Chia PZ,Chen W

更新日期：2014-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a key growth factor driving angiogenesis (i.e. the formation of new blood vessels) in health and disease. Pharmacological blockade of VEGF signaling to inhibit tumor angiogenesis is clinically approved but the survival benefit is limited as patients invariably acquire resis...

journal_title：Cytokine & growth factor reviews

authors： Moens S,Goveia J,Stapor PC,Cantelmo AR,Carmeliet P

更新日期：2014-08-01 00:00:00

abstract：:HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarize...

journal_title：Cytokine & growth factor reviews

authors： Morandi F,Rouas-Freiss N,Pistoia V

更新日期：2014-06-01 00:00:00

abstract：:Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are imp...

journal_title：Cytokine & growth factor reviews

authors： Holien T,Sundan A

更新日期：2014-06-01 00:00:00

abstract：:Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelial receptor tyrosine kinase Tie2. Signalling by angiopoietin-1 promotes vascular endothelial cell survival and the sprouting and reorganisation of blood vessels, as well as inhibiting activation of the vascular endothelial barrier to reduce leakage...

journal_title：Cytokine & growth factor reviews

authors： Moss A

更新日期：2013-12-01 00:00:00

abstract：:CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting...

journal_title：Cytokine & growth factor reviews

authors： Rotondi M,Coperchini F,Chiovato L

更新日期：2013-12-01 00:00:00

abstract：:Members of the transforming growth factor β (TGF-β) family regulate fundamental physiological process, such as cell growth, differentiation and apoptosis. As a result, defects in this pathway have been linked to uncontrolled proliferation and cancer progression. Here we explore the signal transduction mechanism of TGF...

journal_title：Cytokine & growth factor reviews

authors： Marino FE,Risbridger G,Gold E

更新日期：2013-10-01 00:00:00