Abstract:
:Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are important for several aspects of myeloma pathogenesis including growth and survival of tumor cells, bone homeostasis, and anemia. Among cancer cells, myeloma cells are particularly sensitive to growth inhibition and apoptosis induced by BMPs and therefore represent good models to study BMP receptor usage and signaling. Our review highlights and discusses the current knowledge on BMP signaling in myeloma.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Holien T,Sundan Adoi
10.1016/j.cytogfr.2014.04.009subject
Has Abstractpub_date
2014-06-01 00:00:00pages
343-50issue
3eissn
1359-6101issn
1879-0305pii
S1359-6101(14)00042-2journal_volume
25pub_type
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2008.04.010
更新日期:2008-06-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2017.01.002
更新日期:2017-04-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2007.04.010
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.10.001
更新日期:2010-12-01 00:00:00
abstract::The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.07.014
更新日期:2014-08-01 00:00:00
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journal_title:Cytokine & growth factor reviews
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abstract::Adult skeletal muscles are able to regenerate after injury. This process is due to the activation of quiescent muscle precursor cells, also called satellite cells, which proliferate and differentiate to form new myotubes. In this regeneration process, several growth factors which come from the muscle and/or from the m...
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abstract::The wider use of allogeneic stem cell transplantation (allo-SCT) is still limited by the immunologic recognition and destruction of host tissues, termed graft-versus-host disease (GVHD). The role of inflammatory cytokines such as TNF-alpha and IL-1, and their impact on immune effectors (mainly CD4+ and CD8+ T) cells h...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
abstract::Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title:Cytokine & growth factor reviews
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abstract::TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...
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abstract::The exposure of cells to TGF-beta1 can trigger a variety of cellular responses including the inhibition of cell growth, migration, differentiation and apoptosis. TGF-beta1-regulated apoptosis is cell type and context-dependent, indeed TGF-beta1 provides signals for both cell survival or apoptosis. The molecular mechan...
journal_title:Cytokine & growth factor reviews
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abstract::Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover,...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
abstract::A family of latent cytoplasmic transcription factors termed Stats are activated by a variety of cytokines, and are then translocated into the nucleus where they activate transcription. Recent advances in nuclear protein import have shown that the extracellular signal-dependent nuclear import of Stat1 is mediated via c...
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