Inflammatory cytokines and dendritic cells in acute graft-versus-host disease after allogeneic stem cell transplantation.


:The wider use of allogeneic stem cell transplantation (allo-SCT) is still limited by the immunologic recognition and destruction of host tissues, termed graft-versus-host disease (GVHD). The role of inflammatory cytokines such as TNF-alpha and IL-1, and their impact on immune effectors (mainly CD4+ and CD8+ T) cells has been extensively studied in the context of GVHD occurring after standard myeloablative allo-SCT. However, recent data suggested that GVHD pathophysiology is likely to involve more complex interactions where antigen-presenting cells, especially dendritic cells (DCs), may play a major role at time of initiation of acute GVHD. In addition, the wider use of reduced intensity and less toxic conditioning (RIC) regimens prior to allo-SCT would allow better visualization of the fine functions of immune effectors, thereby offering a window of opportunities to better decipher the intimate pathophysiological mechanisms underlying GVHD. The aim of this work is to review the available research evidence on the role of DCs as in vivo regulators of alloimmune reactivity, and their interactions with other immune effectors.


Mohty M,Gaugler B




Has Abstract


2008-02-01 00:00:00














  • Chemokines in disease models and pathogenesis.

    abstract::Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effect...

    journal_title:Cytokine & growth factor reviews



    authors: Bacon KB,Oppenheim JJ

    更新日期:1998-06-01 00:00:00

  • The emerging role of soluble HLA-G in the control of chemotaxis.

    abstract::HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarize...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Morandi F,Rouas-Freiss N,Pistoia V

    更新日期:2014-06-01 00:00:00

  • The angiopoietin:Tie 2 interaction: a potential target for future therapies in human vascular disease.

    abstract::Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelial receptor tyrosine kinase Tie2. Signalling by angiopoietin-1 promotes vascular endothelial cell survival and the sprouting and reorganisation of blood vessels, as well as inhibiting activation of the vascular endothelial barrier to reduce leakage...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Moss A

    更新日期:2013-12-01 00:00:00

  • Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

    abstract::Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seo YJ,Alexander S,Hahm B

    更新日期:2011-02-01 00:00:00

  • ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.

    abstract::Interferon (IFN) induces gene expression by phosphorylating latent transcription factors of the STAT family. Two different STAT multimeric complexes that bind distinct enhancer elements are activated by IFN alpha and IFN gamma, dictated by the DNA-binding protein ISGF3 gamma p48. This protein, a member of the IFN regu...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Bluyssen AR,Durbin JE,Levy DE

    更新日期:1996-06-01 00:00:00

  • The RGM/DRAGON family of BMP co-receptors.

    abstract::The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Corradini E,Babitt JL,Lin HY

    更新日期:2009-10-01 00:00:00

  • Regulation of immune cell homeostasis by type I interferons.

    abstract::Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mattei F,Schiavoni G,Tough DF

    更新日期:2010-08-01 00:00:00

  • Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models.

    abstract::TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF med...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kruglov AA,Kuchmiy A,Grivennikov SI,Tumanov AV,Kuprash DV,Nedospasov SA

    更新日期:2008-06-01 00:00:00

  • IL-2 and autoimmune disease.

    abstract::A decade after the first description of IL-2-deficient mice, the redundancy of IL-2 as a T cell growth factor is well accepted and the focus of research has shifted to the unexpected multiorgan autoimmunity and inflammation observed in mice lacking components of the IL-2/IL-2R system. So far, a set of defects at the l...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


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    更新日期:2002-08-01 00:00:00

  • Acute induction and priming for cytokine production in lymphocytes.

    abstract::When T-lymphocytes (CD4+, CD8+, or TCR gamma delta +) and NK cells proliferate in vivo or in vitro in response to exposure to antigen or other stimuli, they often segregate into subsets with the ability to produce either type-1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] or type-2 cytokines (IL-4, IL-5, IL...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


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  • Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.

    abstract::Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respect...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Hermanns HM

    更新日期:2015-10-01 00:00:00

  • Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis.

    abstract::Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferatio...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


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  • Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression.

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


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  • S100A7: A rAMPing up AMP molecule in psoriasis.

    abstract::S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: D'Amico F,Skarmoutsou E,Granata M,Trovato C,Rossi GA,Mazzarino MC

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  • Roles of activin in tissue repair, fibrosis, and inflammatory disease.

    abstract::Activins are transforming growth factor beta superfamily members, which were originally identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, however, additional functions of activins have been discovered, including a role in the morphogenesis of various tissues and organs...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Werner S,Alzheimer C

    更新日期:2006-06-01 00:00:00

  • Cell-autonomous and non-cell-autonomous functions of caspase-8.

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章


    authors: Ben Moshe T,Kang TB,Kovalenko A,Barash H,Abramovitch R,Galun E,Wallach D

    更新日期:2008-06-01 00:00:00

  • Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee.

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Xie J,Huang Z,Yu X,Zhou L,Pei F

    更新日期:2019-04-01 00:00:00

  • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

    abstract::Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kim HP,Imbert J,Leonard WJ

    更新日期:2006-10-01 00:00:00

  • Cytokine adjuvants for vaccine therapy of neoplastic and infectious disease.

    abstract::Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...

    journal_title:Cytokine & growth factor reviews

    pub_type: 历史文章,杂志文章,评审


    authors: Decker WK,Safdar A

    更新日期:2011-08-01 00:00:00

  • Dually modified transmembrane proteoglycans in development and disease.

    abstract::Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Jenkins LM,Horst B,Lancaster CL,Mythreye K

    更新日期:2018-02-01 00:00:00

  • Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.

    abstract::Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mattila MM,Härkönen PL

    更新日期:2007-06-01 00:00:00

  • New polyprenyl phosphate based preparation Fortepren(®) as promising cytokine regulationg antiviral remedy.

    abstract::Fortepren(®), a product of the phosphorylation of polyprenols from fir needles (with sodium polyprenyl phosphate being the main active ingredient), belongs to the class of antiviral drugs with immunomodulating activity. Fortepren(®) may be used as the drug of choice in the treatment of herpes diseases. It was shown th...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Pronin AV,Narovlyansky AN,Shulzhenko AE,Sanin AV,Sedov AM

    更新日期:2016-08-01 00:00:00

  • Modulation of Wnt signaling by Axin and Axil.

    abstract::The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. The molecular mechanisms by which the Wnt signal regulates cellular functions are becoming increasingly well understood. Wnt stabilizes cytoplasmic bet...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kikuchi A

    更新日期:1999-09-01 00:00:00

  • Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor.

    abstract::Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Nanba D,Higashiyama S

    更新日期:2004-02-01 00:00:00

  • SOST/sclerostin, an osteocyte-derived negative regulator of bone formation.

    abstract::Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcript...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: van Bezooijen RL,ten Dijke P,Papapoulos SE,Löwik CW

    更新日期:2005-06-01 00:00:00

  • Growth factors in skeletal muscle regeneration.

    abstract::Adult skeletal muscles are able to regenerate after injury. This process is due to the activation of quiescent muscle precursor cells, also called satellite cells, which proliferate and differentiate to form new myotubes. In this regeneration process, several growth factors which come from the muscle and/or from the m...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Husmann I,Soulet L,Gautron J,Martelly I,Barritault D

    更新日期:1996-10-01 00:00:00

  • Serum amyloid A and inflammasome activation: A link to breast cancer progression?

    abstract::Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章


    authors: Fourie C,Shridas P,Davis T,de Villiers WJS,Engelbrecht AM

    更新日期:2020-10-27 00:00:00

  • Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers.

    abstract::Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Oudshoorn D,Versteeg GA,Kikkert M

    更新日期:2012-12-01 00:00:00

  • Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors.

    abstract::Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seliger B

    更新日期:2017-08-01 00:00:00

  • Adiponectin: a biomarker for rheumatoid arthritis?

    abstract::Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications,...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Chen X,Lu J,Bao J,Guo J,Shi J,Wang Y

    更新日期:2013-02-01 00:00:00