Abstract：
:The wider use of allogeneic stem cell transplantation (allo-SCT) is still limited by the immunologic recognition and destruction of host tissues, termed graft-versus-host disease (GVHD). The role of inflammatory cytokines such as TNF-alpha and IL-1, and their impact on immune effectors (mainly CD4+ and CD8+ T) cells has been extensively studied in the context of GVHD occurring after standard myeloablative allo-SCT. However, recent data suggested that GVHD pathophysiology is likely to involve more complex interactions where antigen-presenting cells, especially dendritic cells (DCs), may play a major role at time of initiation of acute GVHD. In addition, the wider use of reduced intensity and less toxic conditioning (RIC) regimens prior to allo-SCT would allow better visualization of the fine functions of immune effectors, thereby offering a window of opportunities to better decipher the intimate pathophysiological mechanisms underlying GVHD. The aim of this work is to review the available research evidence on the role of DCs as in vivo regulators of alloimmune reactivity, and their interactions with other immune effectors.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Mohty M,Gaugler Bdoi
10.1016/j.cytogfr.2007.10.010subject
Has Abstractpub_date
2008-02-01 00:00:00pages
53-63issue
1eissn
1359-6101issn
1879-0305pii
S1359-6101(07)00109-8journal_volume
19pub_type
杂志文章,评审abstract：:Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The a...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.10.008
更新日期：2020-11-02 00:00:00
abstract：:Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications,...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.07.004
更新日期：2013-02-01 00:00:00
abstract：:Normal signaling by TGFbeta, in the absence of serum or exogenous factors, involves a rapid activation of Ras, Erks, and Sapks in proliferating cultures of TGFbeta-sensitive untransformed epithelial cells and human carcinoma cells. Expression of either RasN17 or dominant-negative (DN) MKK4, or addition of the MEK1 inh...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(99)00026-x
更新日期：2000-03-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of this cytokine family play key, non-redundant role...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.007
更新日期：2015-10-01 00:00:00
abstract：:Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes. Opn exists both intra- and extracellularly and in numerous pre- and post-translational isoforms. Structurally Opn resembles a matrix pr...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00055-8
更新日期：2003-12-01 00:00:00
abstract：:The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of older age and with medical comorbidities like cancer and d...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.05.001
更新日期：2020-06-01 00:00:00
abstract：:Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.12.001
更新日期：2011-02-01 00:00:00
abstract：:The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.06.003
更新日期：2016-12-01 00:00:00
abstract：:Dendritic cells (DCs) are powerful sensors of foreign pathogens as well as cancer cells and provide the first line of defence against infection. They also serve as a major link between innate and adaptive immunity. Immature DCs respond to incoming danger signals and undergo maturation to produce high levels of proinfl...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.06.008
更新日期：2007-10-01 00:00:00
abstract：:Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ f...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.08.004
更新日期：2020-08-30 00:00:00
abstract：:Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and impaired quality of life and no curative treatments exist. Increasing evidence indicates that low-grade inflammation plays a pivotal role in the onset and progression of OA. In this review, we summarize emerging findings on the...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2019.03.004
更新日期：2019-04-01 00:00:00
abstract：:A unique population of CD4(+) T lymphocytes that constitutively express CD25 has been recognized as anergic/suppressor cells. While the immunosuppressive activity of these CD4(+)CD25(+) cells has been validated and implicated in tolerance, autoimmunity, transplantation, cancer and infectious diseases, the mechanism(s)...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00003-0
更新日期：2003-04-01 00:00:00
abstract：:CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis. Members that co...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.04.007
更新日期：2005-12-01 00:00:00
abstract：:Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.08.003
更新日期：2012-12-01 00:00:00
abstract：:A number of cell surface growth factor receptors are subject to presenilin-dependent regulated intramembrane proteolysis (PS-RIP) after ligand binding and/or ectodomain cleavage. PS-RIP is mediated by a highly conserved multi-component membrane-bound protease, termed gamma-secretase, responsible for generating Alzheim...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.04.001
更新日期：2004-10-01 00:00:00
abstract：:TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(99)00036-2
更新日期：2000-03-01 00:00:00
abstract：:Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.06.016
更新日期：2007-10-01 00:00:00
abstract：:The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian con...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.03.005
更新日期：2013-06-01 00:00:00
abstract：:MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenil...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.12.004
更新日期：2018-02-01 00:00:00
abstract：:Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2019.03.001
更新日期：2019-12-01 00:00:00
abstract：:Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.012
更新日期：2007-06-01 00:00:00
abstract：:Pancreatic cancer is a lethal disease with limited treatment options for cure. A high degree of intrinsic and acquired therapeutic resistance may result from cellular alterations in genes and proteins involved in drug transportation and metabolism, or from the influences of cancer microenvironment. Mechanistic basis f...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.07.011
更新日期：2020-10-01 00:00:00
abstract：:S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.01.002
更新日期：2016-12-01 00:00:00
abstract：:Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH(2)-terminal processing, one or more of the CC chemok...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(02)00045-x
更新日期：2002-12-01 00:00:00
abstract：:The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. ope...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2009.01.004
更新日期：2009-02-01 00:00:00
abstract：:MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2011.05.002
更新日期：2011-06-01 00:00:00
abstract：:Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.04.002
更新日期：2020-06-01 00:00:00
abstract：:Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF med...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2008.04.010
更新日期：2008-06-01 00:00:00
