Abstract:
:The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian contribution to this field has been substantial, with the initial discovery of SOCS1 by Hilton, Starr and colleagues (discovered concurrently by two other groups) and the following work, providing a new perspective on the regulation of JAK/STAT signaling. In this review, we reflect on the critical discoveries that have lead to our current understanding of how SOCS proteins function and discuss what we see as important questions for future research.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Linossi EM,Babon JJ,Hilton DJ,Nicholson SEdoi
10.1016/j.cytogfr.2013.03.005subject
Has Abstractpub_date
2013-06-01 00:00:00pages
241-8issue
3eissn
1359-6101issn
1879-0305pii
S1359-6101(13)00023-3journal_volume
24pub_type
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