Abstract：
:Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in cellular self-destruction dictated through the extrinsic cell-death pathway. Later studies revealed that it also participates in mechanisms affecting cell growth and survival. This essay presents a brief account of a study indicating that, apart from functional changes that are cell autonomous, tissue-specific deletion of caspase-8 in mice also has non-cell-autonomous effects with consequences that might even be the opposite of the cell-autonomous ones.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Ben Moshe T,Kang TB,Kovalenko A,Barash H,Abramovitch R,Galun E,Wallach Ddoi
10.1016/j.cytogfr.2008.04.012subject
Has Abstractpub_date
2008-06-01 00:00:00pages
209-17issue
3-4eissn
1359-6101issn
1879-0305pii
S1359-6101(08)00045-2journal_volume
19pub_type
杂志文章abstract：:Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...
journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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abstract：:Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.05.004
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.10.001
更新日期：2010-12-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.04.007
更新日期：2005-12-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.07.003
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：1996-10-01 00:00:00
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.03.005
更新日期：2013-06-01 00:00:00
abstract：:The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the...
journal_title：Cytokine & growth factor reviews
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doi：10.1016/j.cytogfr.2014.07.014
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abstract：:Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...
journal_title：Cytokine & growth factor reviews
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.cytogfr.2011.07.001
更新日期：2011-08-01 00:00:00
abstract：:The exposure of cells to TGF-beta1 can trigger a variety of cellular responses including the inhibition of cell growth, migration, differentiation and apoptosis. TGF-beta1-regulated apoptosis is cell type and context-dependent, indeed TGF-beta1 provides signals for both cell survival or apoptosis. The molecular mechan...
journal_title：Cytokine & growth factor reviews
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doi：10.1016/j.cytogfr.2004.11.002
更新日期：2005-02-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.09.002
更新日期：2004-12-01 00:00:00
abstract：:Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effect...
journal_title：Cytokine & growth factor reviews
pub_type：
doi：10.1016/s1359-6101(98)00005-7
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abstract：:Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...
journal_title：Cytokine & growth factor reviews
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更新日期：2012-12-01 00:00:00
