C-type lectins, fungi and Th17 responses.

Abstract:

:Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which are capable of regulating the balance between Th1 and Th17 responses has been of particular recent interest, which they control, in part, though the release of Th17 inducing cytokines. Many of these receptors recognise fungi, and other pathogens, and play key roles in driving the development of protective anti-microbial immunity. Here we will review the C-type lectins that have been linked to Th17 type responses and will briefly examine the role of Th17 responses in murine and human anti-fungal immunity.

authors

Vautier S,Sousa Mda G,Brown GD

doi

10.1016/j.cytogfr.2010.10.001

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

405-12

issue

6

eissn

1359-6101

issn

1879-0305

pii

S1359-6101(10)00068-7

journal_volume

21

pub_type

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