Abstract:
:Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which are capable of regulating the balance between Th1 and Th17 responses has been of particular recent interest, which they control, in part, though the release of Th17 inducing cytokines. Many of these receptors recognise fungi, and other pathogens, and play key roles in driving the development of protective anti-microbial immunity. Here we will review the C-type lectins that have been linked to Th17 type responses and will briefly examine the role of Th17 responses in murine and human anti-fungal immunity.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Vautier S,Sousa Mda G,Brown GDdoi
10.1016/j.cytogfr.2010.10.001subject
Has Abstractpub_date
2010-12-01 00:00:00pages
405-12issue
6eissn
1359-6101issn
1879-0305pii
S1359-6101(10)00068-7journal_volume
21pub_type
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