Chemokines in disease models and pathogenesis.


:Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effects of chemokines in animal models were interspersed with talks on fundamental chemokine structure-function relationships, signal transduction, the role of chemokine in cell trafficking, inflammation, immunity and hematopoietic development. Although it was impossible to consider the score of chemokine receptors and the 50 or more chemokines cloned to date, most of the more well established and some of the newer chemokines were discussed. We will first summarize the preconference symposium on the role of chemokines in neurobiology and then review the various issues addressed by the other speakers to provide a more integrated rather than sequential summary of the proceedings.


Bacon KB,Oppenheim JJ




Has Abstract


1998-06-01 00:00:00














  • TGF-beta and cancer.

    abstract::TGF-beta signaling regulates tumorigenesis and in human cancer its signaling pathways are often modified during tumor progression. Prior to initiation and early during progression TGF-beta acts upon the epithelium as a tumor suppressor, however at later stages it is often a tumor promoter. Over the years, many studies...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Bierie B,Moses HL

    更新日期:2006-02-01 00:00:00

  • Role of Ras and Mapks in TGFbeta signaling.

    abstract::Normal signaling by TGFbeta, in the absence of serum or exogenous factors, involves a rapid activation of Ras, Erks, and Sapks in proliferating cultures of TGFbeta-sensitive untransformed epithelial cells and human carcinoma cells. Expression of either RasN17 or dominant-negative (DN) MKK4, or addition of the MEK1 inh...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mulder KM

    更新日期:2000-03-01 00:00:00

  • SOST/sclerostin, an osteocyte-derived negative regulator of bone formation.

    abstract::Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcript...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: van Bezooijen RL,ten Dijke P,Papapoulos SE,Löwik CW

    更新日期:2005-06-01 00:00:00

  • Loss of Smad3 modulates wound healing.

    abstract::TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ashcroft GS,Roberts AB

    更新日期:2000-03-01 00:00:00

  • Serum amyloid A and inflammasome activation: A link to breast cancer progression?

    abstract::Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章


    authors: Fourie C,Shridas P,Davis T,de Villiers WJS,Engelbrecht AM

    更新日期:2020-10-27 00:00:00

  • The therapeutic potential of blocking the activin signalling pathway.

    abstract::Members of the transforming growth factor β (TGF-β) family regulate fundamental physiological process, such as cell growth, differentiation and apoptosis. As a result, defects in this pathway have been linked to uncontrolled proliferation and cancer progression. Here we explore the signal transduction mechanism of TGF...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Marino FE,Risbridger G,Gold E

    更新日期:2013-10-01 00:00:00

  • The response of mammalian cells to double-stranded RNA.

    abstract::Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Gantier MP,Williams BR

    更新日期:2007-10-01 00:00:00

  • Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor.

    abstract::Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Nanba D,Higashiyama S

    更新日期:2004-02-01 00:00:00

  • Macrophage inflammatory protein-1.

    abstract::Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH(2)-terminal processing, one or more of the CC chemok...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Menten P,Wuyts A,Van Damme J

    更新日期:2002-12-01 00:00:00

  • The role of ephrins and Eph receptors in cancer.

    abstract::Eph receptors are the largest receptor tyrosine kinase family of transmembrane proteins with an extracellular domain capable of recognizing signals from the cells' environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and stimulate bi-directional signaling of th...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Surawska H,Ma PC,Salgia R

    更新日期:2004-12-01 00:00:00

  • Pharmacogenomics of Type I interferon therapy: a survey of response-modifying genes.

    abstract::Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: O'Doherty C,Villoslada P,Vandenbroeck K

    更新日期:2007-06-01 00:00:00

  • IL-2 and autoimmune disease.

    abstract::A decade after the first description of IL-2-deficient mice, the redundancy of IL-2 as a T cell growth factor is well accepted and the focus of research has shifted to the unexpected multiorgan autoimmunity and inflammation observed in mice lacking components of the IL-2/IL-2R system. So far, a set of defects at the l...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Schimpl A,Berberich I,Kneitz B,Krämer S,Santner-Nanan B,Wagner S,Wolf M,Hünig T

    更新日期:2002-08-01 00:00:00

  • C-type lectins, fungi and Th17 responses.

    abstract::Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Vautier S,Sousa Mda G,Brown GD

    更新日期:2010-12-01 00:00:00

  • Adiponectin: a biomarker for rheumatoid arthritis?

    abstract::Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications,...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Chen X,Lu J,Bao J,Guo J,Shi J,Wang Y

    更新日期:2013-02-01 00:00:00

  • Infection and cancer: the common vein.

    abstract::The role of infectious agents in the development of cancer is well documented. The pathogenesis of various human neoplasms ranging from non-Hodgkin lymphoma (NHL) to cervical carcinoma frequently involves a chronic, most often viral, infection. At the same time, there is compelling evidence that certain acute infectio...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Thomas-Tikhonenko A,Hunter CA

    更新日期:2003-02-01 00:00:00

  • Chemokines in cancer.

    abstract::Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the host response during infection and inflammation. Most of these mechanisms are also operating in cancer. The stimulation of angiogenesis and tumor growth--directly or indirectly through the recruitment of tumor-associated macrop...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Vicari AP,Caux C

    更新日期:2002-04-01 00:00:00

  • Heparin-binding EGF-like growth factor: a juxtacrine growth factor.

    abstract::Heparin-binding EGF-like growth factor (HB-EGF), which belongs to the EGF-family growth factors, is synthesized as a membrane-anchored form (proHB-EGF). Proteolytic cleavage of proHB-EGF at the extracellular domain yields the soluble form of HB-EGF (sHB-EGF). ProHB-EGF is not only the precursor molecule for sHB-EGF bu...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Iwamoto R,Mekada E

    更新日期:2000-12-01 00:00:00

  • Targeting the extrinsic apoptosis pathway in cancer.

    abstract::Mutational inactivation of the p53 tumor-suppressor gene, which regulates apoptosis mainly via the cell-intrinsic pathway, reduces the sensitivity of many cancers to conventional treatments. Targeting the cell-extrinsic pathway, which triggers p53-independent apoptosis, offers a unique therapeutic strategy to induce a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ashkenazi A

    更新日期:2008-06-01 00:00:00

  • Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

    abstract::Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seo YJ,Alexander S,Hahm B

    更新日期:2011-02-01 00:00:00

  • Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis.

    abstract::Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferatio...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Avau A,Put K,Wouters CH,Matthys P

    更新日期:2015-02-01 00:00:00

  • Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee.

    abstract::Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and impaired quality of life and no curative treatments exist. Increasing evidence indicates that low-grade inflammation plays a pivotal role in the onset and progression of OA. In this review, we summarize emerging findings on the...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Xie J,Huang Z,Yu X,Zhou L,Pei F

    更新日期:2019-04-01 00:00:00

  • The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

    abstract::Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Shu C,Li X,Li P

    更新日期:2014-12-01 00:00:00

  • Dually modified transmembrane proteoglycans in development and disease.

    abstract::Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Jenkins LM,Horst B,Lancaster CL,Mythreye K

    更新日期:2018-02-01 00:00:00

  • Thrombopoietin: a pan-hematopoietic cytokine.

    abstract::The recent discovery of thrombopoietin has enhanced our understanding of both hematopoiesis and platelet production. Thrombopoietin supports hematopoietic stem cell survival and expansion as well as promoting all aspects of megakaryocyte development. The hormone displays many structural similarities to other members o...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Geddis AE,Linden HM,Kaushansky K

    更新日期:2002-02-01 00:00:00

  • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

    abstract::Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kim HP,Imbert J,Leonard WJ

    更新日期:2006-10-01 00:00:00

  • Growth factors in skeletal muscle regeneration.

    abstract::Adult skeletal muscles are able to regenerate after injury. This process is due to the activation of quiescent muscle precursor cells, also called satellite cells, which proliferate and differentiate to form new myotubes. In this regeneration process, several growth factors which come from the muscle and/or from the m...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Husmann I,Soulet L,Gautron J,Martelly I,Barritault D

    更新日期:1996-10-01 00:00:00

  • Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.

    abstract::Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mattila MM,Härkönen PL

    更新日期:2007-06-01 00:00:00

  • ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.

    abstract::The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Radetskyy R,Daher A,Gatignol A

    更新日期:2018-04-01 00:00:00

  • The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction.

    abstract::Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal o...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Adamopoulos IE,Pflanz S

    更新日期:2013-04-01 00:00:00

  • Engineering and combining oncolytic measles virus for cancer therapy.

    abstract::Cancer immunotherapy using tumor-selective, oncolytic viruses is an emerging therapeutic option for solid and hematologic malignancies. A considerable variety of viruses ranging from small picornaviruses to large poxviruses are currently being investigated as potential candidates. In the early days of virotherapy, non...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Leber MF,Neault S,Jirovec E,Barkley R,Said A,Bell JC,Ungerechts G

    更新日期:2020-12-01 00:00:00