Abstract:
:The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Each member of the Axl RTK subfamily possesses distinct expression profiles as well as discrete functions. In this article, we review the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs. In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Hafizi S,Dahlbäck Bdoi
10.1016/j.cytogfr.2006.04.004subject
Has Abstractpub_date
2006-08-01 00:00:00pages
295-304issue
4eissn
1359-6101issn
1879-0305pii
S1359-6101(06)00028-1journal_volume
17pub_type
杂志文章,评审abstract::Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which are ineffective, with robust diagnostic options also being limited. The prostate specific antigen (PSA) test, for instance, is su...
journal_title:Cytokine & growth factor reviews
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doi:10.1016/j.cytogfr.2012.04.004
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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abstract::A decade after the first description of IL-2-deficient mice, the redundancy of IL-2 as a T cell growth factor is well accepted and the focus of research has shifted to the unexpected multiorgan autoimmunity and inflammation observed in mice lacking components of the IL-2/IL-2R system. So far, a set of defects at the l...
journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2011.09.004
更新日期:2011-10-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.06.002
更新日期:2016-12-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2004.11.002
更新日期:2005-02-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2013.04.006
更新日期:2013-10-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(99)00017-9
更新日期:1999-09-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2013.03.005
更新日期:2013-06-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.06.006
更新日期:2014-12-01 00:00:00
abstract::Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2007.04.012
更新日期:2007-06-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/1359-6101(96)00018-4
更新日期:1996-08-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2004.09.002
更新日期:2004-12-01 00:00:00
abstract::Ectodysplasin (Eda), a signaling molecule belonging to the tumor necrosis factor family, is required for normal development of several ectodermally derived organs in humans and mice. Two closely related isoforms of ectodysplasin, Eda-A1 and Eda-A2, have been described which bind to and activate two different receptors...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00020-0
更新日期:2003-06-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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abstract::The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leadi...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(98)80005-1
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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abstract::The coronavirus disease 19 (COVID-19) outbreak caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) had turned out to be highly pathogenic and transmittable. Researchers throughout the globe are still struggling to understand this strain's aggressiveness in search of putative therapies for its contro...
journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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abstract::Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF med...
journal_title:Cytokine & growth factor reviews
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abstract::The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. ope...
journal_title:Cytokine & growth factor reviews
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abstract::Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover,...
journal_title:Cytokine & growth factor reviews
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abstract::Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...
journal_title:Cytokine & growth factor reviews
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doi:10.1016/j.cytogfr.2018.01.002
更新日期:2018-02-01 00:00:00
abstract::The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...
journal_title:Cytokine & growth factor reviews
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doi:10.1016/j.cytogfr.2018.03.007
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abstract::The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of older age and with medical comorbidities like cancer and d...
journal_title:Cytokine & growth factor reviews
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