ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.


:The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISGs show proapoptotic or proviral activity. One of the most studied ISGs, the RNA activated Protein Kinase (PKR), shuts down the viral protein synthesis upon activation. HIV-1 has evolved to evade its inhibition by PKR through viral and cellular mechanisms. One of the cellular mechanisms is the induction of another ISG, the Adenosine Deaminase acting on RNA 1 (ADAR1). ADAR1 promotes viral replication by acting as an RNA sensing inhibitor, by editing viral RNA and by inhibiting PKR. This review challenges the orthodox dogma of ISGs as antiviral proteins, by demonstrating that two ISGs have opposing and clashing effects on viral replication.


Radetskyy R,Daher A,Gatignol A




Has Abstract


2018-04-01 00:00:00












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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Corradini E,Babitt JL,Lin HY

    更新日期:2009-10-01 00:00:00

  • TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression.

    abstract::A unique population of CD4(+) T lymphocytes that constitutively express CD25 has been recognized as anergic/suppressor cells. While the immunosuppressive activity of these CD4(+)CD25(+) cells has been validated and implicated in tolerance, autoimmunity, transplantation, cancer and infectious diseases, the mechanism(s)...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Chen W,Wahl SM

    更新日期:2003-04-01 00:00:00

  • The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.

    abstract::Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Paz S,Ritchie A,Mauer C,Caputi M

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  • Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression.

    abstract::Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which are ineffective, with robust diagnostic options also being limited. The prostate specific antigen (PSA) test, for instance, is su...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ottley E,Gold E

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    journal_title:Cytokine & growth factor reviews

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    authors: Fourie C,Shridas P,Davis T,de Villiers WJS,Engelbrecht AM

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  • Regulation of immune cell homeostasis by type I interferons.

    abstract::Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mattei F,Schiavoni G,Tough DF

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Eswarakumar VP,Lax I,Schlessinger J

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Landman N,Kim TW

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Moss A

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Egwuagu CE,Yu CR,Sun L,Wang R

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Thomas-Tikhonenko A,Hunter CA

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Skoda M,Stangret A,Szukiewicz D

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ashcroft GS,Roberts AB

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Rampino T,Gregorini M,Dal Canton A

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Almasan A,Ashkenazi A

    更新日期:2003-06-01 00:00:00

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    journal_title:Cytokine & growth factor reviews



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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Jafari B,Hamzeh-Mivehroud M,Morris MB,Dastmalchi S

    更新日期:2019-04-01 00:00:00

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Billiau A,Matthys P

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Yu M,Levine SJ

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Breitbach CJ,Reid T,Burke J,Bell JC,Kirn DH

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    pub_type: 杂志文章,评审


    authors: Van Hauwermeiren F,Vandenbroucke RE,Libert C

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mulder KM

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    journal_title:Cytokine & growth factor reviews

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Sun X,Wang T,Cai D,Hu Z,Chen J,Liao H,Zhi L,Wei H,Zhang Z,Qiu Y,Wang J,Wang A

    更新日期:2020-06-01 00:00:00

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    abstract::It is conventional to identify morphogens from fly and frog embryos during morphogenesis using gene-screens, subtractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokin...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Reddi AH

    更新日期:1997-03-01 00:00:00

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Joyce D,Albanese C,Steer J,Fu M,Bouzahzah B,Pestell RG

    更新日期:2001-03-01 00:00:00

  • Impact of tumor microenvironment on oncolytic viral therapy.

    abstract::Interactions between tumor cells and their microenvironment have been shown to play a very significant role in the initiation, progression, and invasiveness of cancer. These tumor-stromal interactions are capable of altering the delivery and effectiveness of therapeutics into the tumor and are also known to influence ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Wojton J,Kaur B

    更新日期:2010-04-01 00:00:00

  • The emerging role of soluble HLA-G in the control of chemotaxis.

    abstract::HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarize...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Morandi F,Rouas-Freiss N,Pistoia V

    更新日期:2014-06-01 00:00:00

  • TGFβ in T cell biology and tumor immunity: Angel or devil?

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    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Tu E,Chia PZ,Chen W

    更新日期:2014-08-01 00:00:00

  • Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors.

    abstract::Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seliger B

    更新日期:2017-08-01 00:00:00