The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction.


:Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal of antagonizing their respective biologic activity through therapeutic neutralizing antibodies. Such, cytokine signaling-dependent molecular networks orchestrate synovial inflammation on multiple levels including differentiation of myeloid cells to osteoclasts, the central cellular players in arthritis-associated pathologic bone resorption. Hence, understanding of the cellular and molecular mechanisms elicited by synovial cytokine networks that dictate recruitment, differentiation and activation of osteoclast precursors and osteoclasts, respectively, is central to shaping novel therapeutic options for inflammatory arthritis patients. In this article we are discussing the complex signaling interactions involved in the regulation of inflammatory arthritis and it's associated bone loss with a focus on Interleukin 27 (IL-27). The present review will discuss the primary bone-degrading cell, the osteoclast, and on how IL-27, directly or indirectly, modulates osteoclast activity in autoimmune-driven inflammatory joint diseases.


Adamopoulos IE,Pflanz S




Has Abstract


2013-04-01 00:00:00














  • Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.

    abstract::Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Egwuagu CE,Yu CR,Sun L,Wang R

    更新日期:2015-10-01 00:00:00

  • The RGM/DRAGON family of BMP co-receptors.

    abstract::The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Corradini E,Babitt JL,Lin HY

    更新日期:2009-10-01 00:00:00

  • Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy.

    abstract::Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. W...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Tian H,Zhao J,Brochmann EJ,Wang JC,Murray SS

    更新日期:2017-04-01 00:00:00

  • Heparin-binding EGF-like growth factor: a juxtacrine growth factor.

    abstract::Heparin-binding EGF-like growth factor (HB-EGF), which belongs to the EGF-family growth factors, is synthesized as a membrane-anchored form (proHB-EGF). Proteolytic cleavage of proHB-EGF at the extracellular domain yields the soluble form of HB-EGF (sHB-EGF). ProHB-EGF is not only the precursor molecule for sHB-EGF bu...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Iwamoto R,Mekada E

    更新日期:2000-12-01 00:00:00

  • Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee.

    abstract::Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and impaired quality of life and no curative treatments exist. Increasing evidence indicates that low-grade inflammation plays a pivotal role in the onset and progression of OA. In this review, we summarize emerging findings on the...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Xie J,Huang Z,Yu X,Zhou L,Pei F

    更新日期:2019-04-01 00:00:00

  • The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

    abstract::Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Shu C,Li X,Li P

    更新日期:2014-12-01 00:00:00

  • Signaling mechanisms through gp130: a model of the cytokine system.

    abstract::The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leadi...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Hirano T,Nakajima K,Hibi M

    更新日期:1997-12-01 00:00:00

  • NF-kappaB and cell-cycle regulation: the cyclin connection.

    abstract::The cyclins are a family of proteins that are centrally involved in cell cycle regulation and which are structurally identified by conserved "cyclin box" regions. They are regulatory subunits of holoenzyme cyclin-dependent kinase (CDK) complexes controlling progression through cell cycle checkpoints by phosphorylating...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Joyce D,Albanese C,Steer J,Fu M,Bouzahzah B,Pestell RG

    更新日期:2001-03-01 00:00:00

  • Chemokines in disease models and pathogenesis.

    abstract::Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effect...

    journal_title:Cytokine & growth factor reviews



    authors: Bacon KB,Oppenheim JJ

    更新日期:1998-06-01 00:00:00

  • CXC chemokines in angiogenesis.

    abstract::CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis. Members that co...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Strieter RM,Burdick MD,Gomperts BN,Belperio JA,Keane MP

    更新日期:2005-12-01 00:00:00

  • Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory?

    abstract::In this review, we discuss our studies on the pathogenesis of collagen-induced arthritis (CIA) and related mouse models for rheumatoid arthritis. Of note, these models invariably rely on the use of complete Freund's adjuvant (CFA). Our analysis has focused on explaining the dichotomous - either protective or disease-p...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Billiau A,Matthys P

    更新日期:2011-10-01 00:00:00

  • Growth factors in skeletal muscle regeneration.

    abstract::Adult skeletal muscles are able to regenerate after injury. This process is due to the activation of quiescent muscle precursor cells, also called satellite cells, which proliferate and differentiate to form new myotubes. In this regeneration process, several growth factors which come from the muscle and/or from the m...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Husmann I,Soulet L,Gautron J,Martelly I,Barritault D

    更新日期:1996-10-01 00:00:00

  • Navigating the clinical development landscape for oncolytic viruses and other cancer therapeutics: no shortcuts on the road to approval.

    abstract::Chemotherapy remains a common mode of anticancer treatment even though in most cancer indications the therapeutic approach is not effective and ultimately associated with the onset of chemoresistance. A better understanding of genetic differences in tumors ushered in the era of targeted therapy which has revolutionize...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Breitbach CJ,Reid T,Burke J,Bell JC,Kirn DH

    更新日期:2010-04-01 00:00:00

  • The role of ephrins and Eph receptors in cancer.

    abstract::Eph receptors are the largest receptor tyrosine kinase family of transmembrane proteins with an extracellular domain capable of recognizing signals from the cells' environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and stimulate bi-directional signaling of th...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Surawska H,Ma PC,Salgia R

    更新日期:2004-12-01 00:00:00

  • WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity.

    abstract::The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Monestier O,Blanquet V

    更新日期:2016-12-01 00:00:00

  • Bone morphogenetic protein signaling in joint homeostasis and disease.

    abstract::Despite advances in therapies that target inflammation and tissue destruction in chronic arthritis, stimulation of tissue repair and restoration of joint function, the ultimate goal of treatment, is far from achieved. We introduce a new paradigm that may help to improve our understanding and management of chronic arth...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Lories RJ,Luyten FP

    更新日期:2005-06-01 00:00:00

  • The therapeutic potential of blocking the activin signalling pathway.

    abstract::Members of the transforming growth factor β (TGF-β) family regulate fundamental physiological process, such as cell growth, differentiation and apoptosis. As a result, defects in this pathway have been linked to uncontrolled proliferation and cancer progression. Here we explore the signal transduction mechanism of TGF...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Marino FE,Risbridger G,Gold E

    更新日期:2013-10-01 00:00:00

  • Pharmacogenomics of Type I interferon therapy: a survey of response-modifying genes.

    abstract::Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: O'Doherty C,Villoslada P,Vandenbroeck K

    更新日期:2007-06-01 00:00:00

  • The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses.

    abstract::Vascular endothelial growth factor (VEGF) is a key growth factor driving angiogenesis (i.e. the formation of new blood vessels) in health and disease. Pharmacological blockade of VEGF signaling to inhibit tumor angiogenesis is clinically approved but the survival benefit is limited as patients invariably acquire resis...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Moens S,Goveia J,Stapor PC,Cantelmo AR,Carmeliet P

    更新日期:2014-08-01 00:00:00

  • Mechanisms involved in the therapeutic properties of mesenchymal stem cells.

    abstract::Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Meirelles Lda S,Fontes AM,Covas DT,Caplan AI

    更新日期:2009-10-01 00:00:00

  • Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens.

    abstract::It is conventional to identify morphogens from fly and frog embryos during morphogenesis using gene-screens, subtractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokin...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Reddi AH

    更新日期:1997-03-01 00:00:00

  • Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.

    abstract::Despite vaccines and antiviral substances influenza still causes significant morbidity and mortality world wide. Better understanding of the molecular mechanisms of influenza virus replication, pathogenesis and host immune responses is required for the development of more efficient means of prevention and treatment of...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Julkunen I,Sareneva T,Pirhonen J,Ronni T,Melén K,Matikainen S

    更新日期:2001-06-01 00:00:00

  • Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers.

    abstract::Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Oudshoorn D,Versteeg GA,Kikkert M

    更新日期:2012-12-01 00:00:00

  • Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor.

    abstract::Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Nanba D,Higashiyama S

    更新日期:2004-02-01 00:00:00

  • Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

    abstract::Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seo YJ,Alexander S,Hahm B

    更新日期:2011-02-01 00:00:00

  • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

    abstract::Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kim HP,Imbert J,Leonard WJ

    更新日期:2006-10-01 00:00:00

  • CXCL8 in thyroid disease: from basic notions to potential applications in clinical practice.

    abstract::CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Rotondi M,Coperchini F,Chiovato L

    更新日期:2013-12-01 00:00:00

  • High efficiency targeting of IFN-α activity: possible applications in fighting tumours and infections.

    abstract::In this short review, we summarize how insights into the structure and dynamics of interferon-receptor complex assembly and activation guided the design of a novel class of engineered type I interferons that combine a largely lost potency on non-targeted cells with high activity on targeted cells. These novel interfer...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Uzé G,Tavernier J

    更新日期:2015-04-01 00:00:00

  • New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis.

    abstract::Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Micera A,Puxeddu I,Aloe L,Levi-Schaffer F

    更新日期:2003-10-01 00:00:00

  • Infection and cancer: the common vein.

    abstract::The role of infectious agents in the development of cancer is well documented. The pathogenesis of various human neoplasms ranging from non-Hodgkin lymphoma (NHL) to cervical carcinoma frequently involves a chronic, most often viral, infection. At the same time, there is compelling evidence that certain acute infectio...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Thomas-Tikhonenko A,Hunter CA

    更新日期:2003-02-01 00:00:00