Abstract：
:Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal of antagonizing their respective biologic activity through therapeutic neutralizing antibodies. Such, cytokine signaling-dependent molecular networks orchestrate synovial inflammation on multiple levels including differentiation of myeloid cells to osteoclasts, the central cellular players in arthritis-associated pathologic bone resorption. Hence, understanding of the cellular and molecular mechanisms elicited by synovial cytokine networks that dictate recruitment, differentiation and activation of osteoclast precursors and osteoclasts, respectively, is central to shaping novel therapeutic options for inflammatory arthritis patients. In this article we are discussing the complex signaling interactions involved in the regulation of inflammatory arthritis and it's associated bone loss with a focus on Interleukin 27 (IL-27). The present review will discuss the primary bone-degrading cell, the osteoclast, and on how IL-27, directly or indirectly, modulates osteoclast activity in autoimmune-driven inflammatory joint diseases.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Adamopoulos IE,Pflanz Sdoi
10.1016/j.cytogfr.2012.10.001subject
Has Abstractpub_date
2013-04-01 00:00:00pages
115-21issue
2eissn
1359-6101issn
1879-0305pii
S1359-6101(12)00078-0journal_volume
24pub_type
杂志文章,评审abstract：:Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.12.001
更新日期：2011-02-01 00:00:00
abstract：:Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcript...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.02.005
更新日期：2005-06-01 00:00:00
abstract：:The main contribution of this article is to report general statistics about COVID-19 in Brazil, based on analysis of accumulated series of confirmed cases, deaths and lethality rates, in addition to presenting graphs of moving averages for states and municipalities. The data show that the pandemic in Brazil has grown ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.10.010
更新日期：2020-11-05 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) has been characterized as an injury-related factor, based on the observation that it is strongly up-regulated in many acute or chronic central nervous system disorders. TGF-beta is generally thought to be neuroprotective and several mechanisms have been proposed to explain th...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.09.011
更新日期：2006-02-01 00:00:00
abstract：:Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.010
更新日期：2007-06-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of this cytokine family play key, non-redundant role...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.007
更新日期：2015-10-01 00:00:00
abstract：:Heparin-binding EGF-like growth factor (HB-EGF), which belongs to the EGF-family growth factors, is synthesized as a membrane-anchored form (proHB-EGF). Proteolytic cleavage of proHB-EGF at the extracellular domain yields the soluble form of HB-EGF (sHB-EGF). ProHB-EGF is not only the precursor molecule for sHB-EGF bu...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(00)00013-7
更新日期：2000-12-01 00:00:00
abstract：:TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF med...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2008.04.010
更新日期：2008-06-01 00:00:00
abstract：:Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. The...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.05.004
更新日期：2020-05-18 00:00:00
abstract：:Cytokines and vitamins play a central role in controlling neoplastic cell growth. The interferon (IFN) family of cytokines regulates antiviral, anti-tumor, antimicrobial, differentiation, and immune responses in mammals. Significant advances have been made with respect to IFN-induced signal transduction pathways and a...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.01.002
更新日期：2004-04-01 00:00:00
abstract：:Cellular adhesion molecules (CAMs) play an essential role in tethering circulating leukocytes to the vascular endothelium at sites of inflammation. They are also instrumental in enabling leukocytes to transmigrate from blood vessels into adjacent inflamed tissues. In the absence of signals to stimulate expression of C...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(98)00024-0
更新日期：1999-03-01 00:00:00
abstract：:Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.06.002
更新日期：2016-12-01 00:00:00
abstract：:Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00047-9
更新日期：2003-10-01 00:00:00
abstract：:The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2009.10.008
更新日期：2009-10-01 00:00:00
abstract：:Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effect...
journal_title：Cytokine & growth factor reviews
pub_type：
doi：10.1016/s1359-6101(98)00005-7
更新日期：1998-06-01 00:00:00
abstract：:Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferatio...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.05.005
更新日期：2015-02-01 00:00:00
abstract：:Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. W...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.01.002
更新日期：2017-04-01 00:00:00
abstract：:Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.07.001
更新日期：2017-08-01 00:00:00
abstract：:Fortepren(®), a product of the phosphorylation of polyprenols from fir needles (with sodium polyprenyl phosphate being the main active ingredient), belongs to the class of antiviral drugs with immunomodulating activity. Fortepren(®) may be used as the drug of choice in the treatment of herpes diseases. It was shown th...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.04.001
更新日期：2016-08-01 00:00:00
abstract：:The role of infectious agents in the development of cancer is well documented. The pathogenesis of various human neoplasms ranging from non-Hodgkin lymphoma (NHL) to cervical carcinoma frequently involves a chronic, most often viral, infection. At the same time, there is compelling evidence that certain acute infectio...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(02)00071-0
更新日期：2003-02-01 00:00:00
abstract：:Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.04.002
更新日期：2020-06-01 00:00:00
abstract：:Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.013
更新日期：2015-10-01 00:00:00
abstract：:The recent discovery of thrombopoietin has enhanced our understanding of both hematopoiesis and platelet production. Thrombopoietin supports hematopoietic stem cell survival and expansion as well as promoting all aspects of megakaryocyte development. The hormone displays many structural similarities to other members o...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(01)00030-2
更新日期：2002-02-01 00:00:00
abstract：:Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2019.03.001
更新日期：2019-12-01 00:00:00
abstract：:Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are imp...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.04.009
更新日期：2014-06-01 00:00:00
abstract：:Members of the transforming growth factor β (TGF-β) family regulate fundamental physiological process, such as cell growth, differentiation and apoptosis. As a result, defects in this pathway have been linked to uncontrolled proliferation and cancer progression. Here we explore the signal transduction mechanism of TGF...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.04.006
更新日期：2013-10-01 00:00:00
abstract：:When T-lymphocytes (CD4+, CD8+, or TCR gamma delta +) and NK cells proliferate in vivo or in vitro in response to exposure to antigen or other stimuli, they often segregate into subsets with the ability to produce either type-1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] or type-2 cytokines (IL-4, IL-5, IL...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/1359-6101(96)00018-4
更新日期：1996-08-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is a known target in cancer therapy and targeting the receptor has proven to be extremely successful in treating cancers that are dependent on EGFR signaling. To that effect, targeted therapies to EGFR such as Cetuximab, Panitumumab-monoclonal antibodies and Gefitinib, Erlotinib...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.04.002
更新日期：2018-06-01 00:00:00
abstract：:Interest in the biology of white adipose tissue (WAT) has increased dramatically since the discovery of leptin in 1994. The identification of the product of the gene obese (ob) threw light on the role of adipose tissue in the physiopathology of obesity-related diseases, and spurred the identification of numerous other...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.007
更新日期：2007-06-01 00:00:00
abstract：:The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian con...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.03.005
更新日期：2013-06-01 00:00:00
