Abstract:
:The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. operate an integrated program that seems tailored to drive organ development and to regenerate injured tissues. On the other hand, Scatter Factors may be responsible for pathologic tissue remodeling, infiltration of inflammatory cells, and tumor growth and diffusion. The review describes the involvement of Scatter Factors in renal disease, including acute renal failure, glomerulonephritis, chronic fibrosing nephropathies, dialysis, renal transplantation and renal tumors, and discusses the double-faced role of Scatter Factors, that play either a protective or a pathogenic role.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Rampino T,Gregorini M,Dal Canton Adoi
10.1016/j.cytogfr.2009.01.004subject
Has Abstractpub_date
2009-02-01 00:00:00pages
77-85issue
1eissn
1359-6101issn
1879-0305pii
S1359-6101(09)00003-3journal_volume
20pub_type
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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pub_type: 杂志文章,评审
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