Abstract:
:The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Ruffell B,DeNardo DG,Affara NI,Coussens LMdoi
10.1016/j.cytogfr.2009.11.002subject
Has Abstractpub_date
2010-02-01 00:00:00pages
3-10issue
1eissn
1359-6101issn
1879-0305pii
S1359-6101(09)00109-9journal_volume
21pub_type
杂志文章,评审abstract::TGF-beta signaling regulates tumorigenesis and in human cancer its signaling pathways are often modified during tumor progression. Prior to initiation and early during progression TGF-beta acts upon the epithelium as a tumor suppressor, however at later stages it is often a tumor promoter. Over the years, many studies...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2005.09.006
更新日期:2006-02-01 00:00:00
abstract::IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22). IL-26 is often co-expres...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.09.001
更新日期:2010-10-01 00:00:00
abstract::S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.01.002
更新日期:2016-12-01 00:00:00
abstract::Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcript...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2005.02.005
更新日期:2005-06-01 00:00:00
abstract::CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2013.08.001
更新日期:2013-12-01 00:00:00
abstract::Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications,...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2012.07.004
更新日期:2013-02-01 00:00:00
abstract::Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...
journal_title:Cytokine & growth factor reviews
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.cytogfr.2011.07.001
更新日期:2011-08-01 00:00:00
abstract::The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.12.006
更新日期:2015-04-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a known target in cancer therapy and targeting the receptor has proven to be extremely successful in treating cancers that are dependent on EGFR signaling. To that effect, targeted therapies to EGFR such as Cetuximab, Panitumumab-monoclonal antibodies and Gefitinib, Erlotinib...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2018.04.002
更新日期:2018-06-01 00:00:00
abstract::In this review, we discuss our studies on the pathogenesis of collagen-induced arthritis (CIA) and related mouse models for rheumatoid arthritis. Of note, these models invariably rely on the use of complete Freund's adjuvant (CFA). Our analysis has focused on explaining the dichotomous - either protective or disease-p...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2011.11.003
更新日期:2011-10-01 00:00:00
abstract::The exposure of cells to TGF-beta1 can trigger a variety of cellular responses including the inhibition of cell growth, migration, differentiation and apoptosis. TGF-beta1-regulated apoptosis is cell type and context-dependent, indeed TGF-beta1 provides signals for both cell survival or apoptosis. The molecular mechan...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2004.11.002
更新日期:2005-02-01 00:00:00
abstract::Activins are transforming growth factor beta superfamily members, which were originally identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, however, additional functions of activins have been discovered, including a role in the morphogenesis of various tissues and organs...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2006.01.001
更新日期:2006-06-01 00:00:00
abstract::The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.06.003
更新日期:2016-12-01 00:00:00
abstract::Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respect...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2015.07.006
更新日期:2015-10-01 00:00:00
abstract::Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes. Opn exists both intra- and extracellularly and in numerous pre- and post-translational isoforms. Structurally Opn resembles a matrix pr...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00055-8
更新日期:2003-12-01 00:00:00
abstract::Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章
doi:10.1016/j.cytogfr.2020.10.006
更新日期:2020-10-27 00:00:00
abstract::Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.06.006
更新日期:2014-12-01 00:00:00
abstract::Ectodysplasin (Eda), a signaling molecule belonging to the tumor necrosis factor family, is required for normal development of several ectodermally derived organs in humans and mice. Two closely related isoforms of ectodysplasin, Eda-A1 and Eda-A2, have been described which bind to and activate two different receptors...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00020-0
更新日期:2003-06-01 00:00:00
abstract::Cellular adhesion molecules (CAMs) play an essential role in tethering circulating leukocytes to the vascular endothelium at sites of inflammation. They are also instrumental in enabling leukocytes to transmigrate from blood vessels into adjacent inflamed tissues. In the absence of signals to stimulate expression of C...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(98)00024-0
更新日期:1999-03-01 00:00:00
abstract::A decade after the first description of IL-2-deficient mice, the redundancy of IL-2 as a T cell growth factor is well accepted and the focus of research has shifted to the unexpected multiorgan autoimmunity and inflammation observed in mice lacking components of the IL-2/IL-2R system. So far, a set of defects at the l...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(02)00022-9
更新日期:2002-08-01 00:00:00
abstract::Despite vaccines and antiviral substances influenza still causes significant morbidity and mortality world wide. Better understanding of the molecular mechanisms of influenza virus replication, pathogenesis and host immune responses is required for the development of more efficient means of prevention and treatment of...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(00)00026-5
更新日期:2001-06-01 00:00:00
abstract::The main contribution of this article is to report general statistics about COVID-19 in Brazil, based on analysis of accumulated series of confirmed cases, deaths and lethality rates, in addition to presenting graphs of moving averages for states and municipalities. The data show that the pandemic in Brazil has grown ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2020.10.010
更新日期:2020-11-05 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role as regulator of hematopoiesis and innate immune responses. There is growing evidence that G-CSF also exerts profound immunoregulatory effects in adaptive immunity. G-CSF mediates anti-inflammatory reactions accompanied by TH2 ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2006.05.002
更新日期:2006-08-01 00:00:00
abstract::Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2017.07.001
更新日期:2017-08-01 00:00:00
abstract::The TNF signaling pathway is a valuable target in the therapy of autoimmune diseases, and anti-TNF drugs are successfully used to treat diseases such as rheumatoid arthritis, Crohn's disease and psoriasis. By their ability to interfere with inflammatory processes at multiple levels, these TNF blockers have become inva...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2011.09.004
更新日期:2011-10-01 00:00:00
abstract::Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) is one of several members of the TNF gene superfamily that induce apoptosis through engagement of death receptors. Apo2L/TRAIL is unusual as compared to any other cytokine as it interacts with a complex system of receptors: two ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00029-7
更新日期:2003-06-01 00:00:00
abstract::Adult skeletal muscles are able to regenerate after injury. This process is due to the activation of quiescent muscle precursor cells, also called satellite cells, which proliferate and differentiate to form new myotubes. In this regeneration process, several growth factors which come from the muscle and/or from the m...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(96)00029-9
更新日期:1996-10-01 00:00:00
abstract::The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of older age and with medical comorbidities like cancer and d...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2020.05.001
更新日期:2020-06-01 00:00:00
abstract::Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2015.07.013
更新日期:2015-10-01 00:00:00
abstract::Chemotherapy remains a common mode of anticancer treatment even though in most cancer indications the therapeutic approach is not effective and ultimately associated with the onset of chemoresistance. A better understanding of genetic differences in tumors ushered in the era of targeted therapy which has revolutionize...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.02.001
更新日期:2010-04-01 00:00:00