Lymphocytes in cancer development: polarization towards pro-tumor immunity.

Abstract:

:The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.

authors

Ruffell B,DeNardo DG,Affara NI,Coussens LM

doi

10.1016/j.cytogfr.2009.11.002

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

3-10

issue

1

eissn

1359-6101

issn

1879-0305

pii

S1359-6101(09)00109-9

journal_volume

21

pub_type

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