Abstract：
:Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by MSCs, such as growth factors, cytokines and chemokines, constitutes their most biologically significant role under injury conditions. Understanding this intricate secretory activity as well as the properties of MSCs in vivo is central to harnessing their clinical potential. Herein, we identify some of the molecules involved in the paracrine effects of MSCs with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and discuss how this knowledge could be advantageously used in clinical applications.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Meirelles Lda S,Fontes AM,Covas DT,Caplan AIdoi
10.1016/j.cytogfr.2009.10.002subject
Has Abstractpub_date
2009-10-01 00:00:00pages
419-27issue
5-6eissn
1359-6101issn
1879-0305pii
S1359-6101(09)00077-Xjournal_volume
20pub_type
杂志文章,评审abstract：:TGF-beta signaling regulates tumorigenesis and in human cancer its signaling pathways are often modified during tumor progression. Prior to initiation and early during progression TGF-beta acts upon the epithelium as a tumor suppressor, however at later stages it is often a tumor promoter. Over the years, many studies...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.09.006
更新日期：2006-02-01 00:00:00
abstract：:Interactions between tumor cells and their microenvironment have been shown to play a very significant role in the initiation, progression, and invasiveness of cancer. These tumor-stromal interactions are capable of altering the delivery and effectiveness of therapeutics into the tumor and are also known to influence ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.02.014
更新日期：2010-04-01 00:00:00
abstract：:Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.04.002
更新日期：2020-06-01 00:00:00
abstract：:The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2009.10.008
更新日期：2009-10-01 00:00:00
abstract：:Tuberculosis is a global health calamity. The causative agent, Mycobacterium tuberculosis (M. tuberculosis), has evolved elaborate survival mechanisms in humans, allowing it to remain in a clinically latent infection state, constantly engaging the immune system, with the possibility to progress to active disease. Auto...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.01.002
更新日期：2013-08-01 00:00:00
abstract：:Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...
journal_title：Cytokine & growth factor reviews
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.cytogfr.2011.07.001
更新日期：2011-08-01 00:00:00
abstract：:Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.08.003
更新日期：2012-12-01 00:00:00
abstract：:The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.03.007
更新日期：2018-04-01 00:00:00
abstract：:The cyclins are a family of proteins that are centrally involved in cell cycle regulation and which are structurally identified by conserved "cyclin box" regions. They are regulatory subunits of holoenzyme cyclin-dependent kinase (CDK) complexes controlling progression through cell cycle checkpoints by phosphorylating...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(00)00018-6
更新日期：2001-03-01 00:00:00
abstract：:Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.06.016
更新日期：2007-10-01 00:00:00
abstract：:Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcript...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.02.005
更新日期：2005-06-01 00:00:00
abstract：:Eph receptors are the largest receptor tyrosine kinase family of transmembrane proteins with an extracellular domain capable of recognizing signals from the cells' environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and stimulate bi-directional signaling of th...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.09.002
更新日期：2004-12-01 00:00:00
abstract：:In this review, we discuss our studies on the pathogenesis of collagen-induced arthritis (CIA) and related mouse models for rheumatoid arthritis. Of note, these models invariably rely on the use of complete Freund's adjuvant (CFA). Our analysis has focused on explaining the dichotomous - either protective or disease-p...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2011.11.003
更新日期：2011-10-01 00:00:00
abstract：:Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章
doi：10.1016/j.cytogfr.2020.10.006
更新日期：2020-10-27 00:00:00
abstract：:A unique population of CD4(+) T lymphocytes that constitutively express CD25 has been recognized as anergic/suppressor cells. While the immunosuppressive activity of these CD4(+)CD25(+) cells has been validated and implicated in tolerance, autoimmunity, transplantation, cancer and infectious diseases, the mechanism(s)...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00003-0
更新日期：2003-04-01 00:00:00
abstract：:The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.12.006
更新日期：2015-04-01 00:00:00
abstract：:Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. ope...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2009.01.004
更新日期：2009-02-01 00:00:00
abstract：:Dendritic cells (DCs) are powerful sensors of foreign pathogens as well as cancer cells and provide the first line of defence against infection. They also serve as a major link between innate and adaptive immunity. Immature DCs respond to incoming danger signals and undergo maturation to produce high levels of proinfl...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.06.008
更新日期：2007-10-01 00:00:00
abstract：:Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which are ineffective, with robust diagnostic options also being limited. The prostate specific antigen (PSA) test, for instance, is su...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：:HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarize...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.04.004
更新日期：2014-06-01 00:00:00
abstract：:A number of cell surface growth factor receptors are subject to presenilin-dependent regulated intramembrane proteolysis (PS-RIP) after ligand binding and/or ectodomain cleavage. PS-RIP is mediated by a highly conserved multi-component membrane-bound protease, termed gamma-secretase, responsible for generating Alzheim...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.04.001
更新日期：2004-10-01 00:00:00
abstract：:The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of thei...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.04.004
更新日期：2006-08-01 00:00:00
abstract：:Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.07.003
更新日期：2006-10-01 00:00:00
abstract：:Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.05.002
更新日期：2010-08-01 00:00:00
abstract：:Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH(2)-terminal processing, one or more of the CC chemok...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(02)00045-x
更新日期：2002-12-01 00:00:00
abstract：:CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.08.001
更新日期：2013-12-01 00:00:00
abstract：:When T-lymphocytes (CD4+, CD8+, or TCR gamma delta +) and NK cells proliferate in vivo or in vitro in response to exposure to antigen or other stimuli, they often segregate into subsets with the ability to produce either type-1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] or type-2 cytokines (IL-4, IL-5, IL...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/1359-6101(96)00018-4
更新日期：1996-08-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of this cytokine family play key, non-redundant role...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.007
更新日期：2015-10-01 00:00:00
abstract：:Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.07.001
更新日期：2017-08-01 00:00:00
