Abstract：
:A decade after the first description of IL-2-deficient mice, the redundancy of IL-2 as a T cell growth factor is well accepted and the focus of research has shifted to the unexpected multiorgan autoimmunity and inflammation observed in mice lacking components of the IL-2/IL-2R system. So far, a set of defects at the levels of repertoire selection, the generation of suppressive regulatory T cells, T cell homing and clonal contraction via activation induced cell death (AICD) have been documented. We propose that these individual defects jointly contribute to the severe disturbance of T cell homeostasis and self-tolerance underlying the immunopathology of the IL-2 deficiency syndrome.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Schimpl A,Berberich I,Kneitz B,Krämer S,Santner-Nanan B,Wagner S,Wolf M,Hünig Tdoi
10.1016/s1359-6101(02)00022-9subject
Has Abstractpub_date
2002-08-01 00:00:00pages
369-78issue
4-5eissn
1359-6101issn
1879-0305pii
S1359610102000229journal_volume
13pub_type
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journal_title：Cytokine & growth factor reviews
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