Abstract：
:Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting variety of effects on inflammation, liver regeneration, and defence against infections by regulating adaptive immunity. Due to its high abundance in inflammatory settings, IL-6 is often viewed as a detrimental cytokine. However, accumulating evidence supports the view that IL-6 has a beneficial impact in numerous liver pathologies, due to its roles in liver regeneration and in promoting an anti-inflammatory response in certain conditions. IL-6 promotes proliferation, angiogenesis and metabolism, and downregulates apoptosis and oxidative stress; together these functions are critical for mediating hepatoprotection. IL-6 is also an important regulator of adaptive immunity where it induces T cell differentiation and regulates autoimmunity. It can augment antiviral adaptive immune responses and mitigate exhaustion of T cells during chronic infection. This review focuses on studies that present IL-6 as a key factor in regulating liver regeneration and in supporting effector immune functions and suggests that these functions of IL-6 can be exploited in treatment strategies for liver pathologies.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Naseem S,Hussain T,Manzoor Sdoi
10.1016/j.cytogfr.2018.01.002subject
Has Abstractpub_date
2018-02-01 00:00:00pages
36-45eissn
1359-6101issn
1879-0305pii
S1359-6101(17)30166-1journal_volume
39pub_type
杂志文章,评审abstract：:Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in canc...
journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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更新日期：2011-08-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.04.004
更新日期：2006-08-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2005-06-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.07.003
更新日期：2006-10-01 00:00:00
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
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更新日期：2016-12-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2011-06-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.01.001
更新日期：2005-04-01 00:00:00
abstract：:The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2009.10.008
更新日期：2009-10-01 00:00:00
