Abstract:
:MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenile idiopathic arthritis, celiac disease and in subjects born intrauterine growth restricted/small for gestational age. Children with inflammatory conditions may also be at risk of developing insulin resistance as a result of the inflammatory process and concurrent therapy. Chronic inflammation may lead to a continuum of abnormalities in the Growth hormone/Insulin-like growth factor 1 (GH/IGF-I) axis, including relative GH insufficiency, GH/IGF-I resistance due to down regulation of GH and IGF-I receptors, changes in GH and IGF-I bioavailability due to modifications of binding proteins, and/or impaired GH/IGF-I signaling. The aim of this review is first to summarize the current knowledge concerning microRNAs involved in inflammation in the most relevant chronic inflammatory diseases in childhood, second to provide new insights into miRNA regulation of growth and insulin sensitivity mediated by the inflammatory processes. We evaluated single microRNAs involved in inflammation in the single conditions mentioned above and verified which had validated and predicted targets within the GH receptor, IGF-I type 1 receptor and insulin receptor interactomes. The findings show a new link among inflammation, growth and insulin sensitivity mediated by miRNAs that warrants further research in the future.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Cirillo F,Lazzeroni P,Catellani C,Sartori C,Amarri S,Street MEdoi
10.1016/j.cytogfr.2017.12.004subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1-18eissn
1359-6101issn
1879-0305pii
S1359-6101(17)30195-8journal_volume
39pub_type
杂志文章,评审abstract::Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2019.03.001
更新日期:2019-12-01 00:00:00
abstract::Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::When T-lymphocytes (CD4+, CD8+, or TCR gamma delta +) and NK cells proliferate in vivo or in vitro in response to exposure to antigen or other stimuli, they often segregate into subsets with the ability to produce either type-1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] or type-2 cytokines (IL-4, IL-5, IL...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/1359-6101(96)00018-4
更新日期:1996-08-01 00:00:00
abstract::IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22). IL-26 is often co-expres...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.09.001
更新日期:2010-10-01 00:00:00
abstract::Pancreatic cancer is a lethal disease with limited treatment options for cure. A high degree of intrinsic and acquired therapeutic resistance may result from cellular alterations in genes and proteins involved in drug transportation and metabolism, or from the influences of cancer microenvironment. Mechanistic basis f...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2020.07.011
更新日期:2020-10-01 00:00:00
abstract::Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the host response during infection and inflammation. Most of these mechanisms are also operating in cancer. The stimulation of angiogenesis and tumor growth--directly or indirectly through the recruitment of tumor-associated macrop...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(01)00033-8
更新日期:2002-04-01 00:00:00
abstract::The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.12.006
更新日期:2015-04-01 00:00:00
abstract::Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2018.01.002
更新日期:2018-02-01 00:00:00
abstract::Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.10.001
更新日期:2010-12-01 00:00:00
abstract::Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2003.10.002
更新日期:2004-02-01 00:00:00
abstract::S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.01.002
更新日期:2016-12-01 00:00:00
abstract::Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2014.06.006
更新日期:2014-12-01 00:00:00
abstract::Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The a...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2020.10.008
更新日期:2020-11-02 00:00:00
abstract::Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes. Opn exists both intra- and extracellularly and in numerous pre- and post-translational isoforms. Structurally Opn resembles a matrix pr...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00055-8
更新日期:2003-12-01 00:00:00
abstract::The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2009.10.008
更新日期:2009-10-01 00:00:00
abstract::Interferon (IFN) induces gene expression by phosphorylating latent transcription factors of the STAT family. Two different STAT multimeric complexes that bind distinct enhancer elements are activated by IFN alpha and IFN gamma, dictated by the DNA-binding protein ISGF3 gamma p48. This protein, a member of the IFN regu...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/1359-6101(96)00005-6
更新日期:1996-06-01 00:00:00
abstract::Interactions between tumor cells and their microenvironment have been shown to play a very significant role in the initiation, progression, and invasiveness of cancer. These tumor-stromal interactions are capable of altering the delivery and effectiveness of therapeutics into the tumor and are also known to influence ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.02.014
更新日期:2010-04-01 00:00:00
abstract::The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.06.003
更新日期:2016-12-01 00:00:00
abstract::Despite advances in therapies that target inflammation and tissue destruction in chronic arthritis, stimulation of tissue repair and restoration of joint function, the ultimate goal of treatment, is far from achieved. We introduce a new paradigm that may help to improve our understanding and management of chronic arth...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2005.02.009
更新日期:2005-06-01 00:00:00
abstract::Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelial receptor tyrosine kinase Tie2. Signalling by angiopoietin-1 promotes vascular endothelial cell survival and the sprouting and reorganisation of blood vessels, as well as inhibiting activation of the vascular endothelial barrier to reduce leakage...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2013.05.009
更新日期:2013-12-01 00:00:00
abstract::Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2015.07.013
更新日期:2015-10-01 00:00:00
abstract::Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2017.12.003
更新日期:2018-02-01 00:00:00
abstract::Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influ...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(03)00047-9
更新日期:2003-10-01 00:00:00
abstract::Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2020.04.002
更新日期:2020-06-01 00:00:00
abstract::Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2007.04.010
更新日期:2007-06-01 00:00:00
abstract::Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2010.12.001
更新日期:2011-02-01 00:00:00
abstract::The exposure of cells to TGF-beta1 can trigger a variety of cellular responses including the inhibition of cell growth, migration, differentiation and apoptosis. TGF-beta1-regulated apoptosis is cell type and context-dependent, indeed TGF-beta1 provides signals for both cell survival or apoptosis. The molecular mechan...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2004.11.002
更新日期:2005-02-01 00:00:00
abstract::Dendritic cells (DCs) are powerful sensors of foreign pathogens as well as cancer cells and provide the first line of defence against infection. They also serve as a major link between innate and adaptive immunity. Immature DCs respond to incoming danger signals and undergo maturation to produce high levels of proinfl...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2007.06.008
更新日期:2007-10-01 00:00:00
abstract::TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(99)00036-2
更新日期:2000-03-01 00:00:00
abstract::Cellular adhesion molecules (CAMs) play an essential role in tethering circulating leukocytes to the vascular endothelium at sites of inflammation. They are also instrumental in enabling leukocytes to transmigrate from blood vessels into adjacent inflamed tissues. In the absence of signals to stimulate expression of C...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/s1359-6101(98)00024-0
更新日期:1999-03-01 00:00:00