Abstract：
:Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed interest in IL-11, because its distinct biological activities associated with cancers of epithelial origin and inflammatory disorders have been revealed. Although the crystal structure of IL-11 was resolved more than two years, a better understanding of the mechanisms of IL-11 action is required to further extend the clinical use of IL-11. This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Negahdaripour M,Nezafat N,Ghasemi Ydoi
10.1016/j.cytogfr.2016.06.002subject
Has Abstractpub_date
2016-12-01 00:00:00pages
41-61eissn
1359-6101issn
1879-0305pii
S1359-6101(16)30038-7journal_volume
32pub_type
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