A panoramic review and in silico analysis of IL-11 structure and function.

Abstract:

:Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed interest in IL-11, because its distinct biological activities associated with cancers of epithelial origin and inflammatory disorders have been revealed. Although the crystal structure of IL-11 was resolved more than two years, a better understanding of the mechanisms of IL-11 action is required to further extend the clinical use of IL-11. This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases.

authors

Negahdaripour M,Nezafat N,Ghasemi Y

doi

10.1016/j.cytogfr.2016.06.002

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

41-61

eissn

1359-6101

issn

1879-0305

pii

S1359-6101(16)30038-7

journal_volume

32

pub_type

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