Abstract：
:Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm2. However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3β downstream activity in diabetic wound healing.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Jere SW,Houreld NN,Abrahamse Hdoi
10.1016/j.cytogfr.2019.03.001subject
Has Abstractpub_date
2019-12-01 00:00:00pages
52-59eissn
1359-6101issn
1879-0305pii
S1359-6101(19)30013-9journal_volume
50pub_type
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.10.001
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.09.002
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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更新日期：2003-06-01 00:00:00
