Abstract:
:Interest in the biology of white adipose tissue (WAT) has increased dramatically since the discovery of leptin in 1994. The identification of the product of the gene obese (ob) threw light on the role of adipose tissue in the physiopathology of obesity-related diseases, and spurred the identification of numerous other adipokines, many of a pro-inflammatory nature. It has become increasingly evident that WAT-derived cytokines mediate between obesity-related exogenous factors (nutrition and lifestyle) and the molecular events that lead to metabolic syndrome and inflammatory and/or autoimmune conditions. Here, we review recent adipokine research, with particular attention to the roles of leptin, adiponectin, resistin, visfatin, apelin, vaspin and hepcidin in such conditions.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Lago F,Dieguez C,Gómez-Reino J,Gualillo Odoi
10.1016/j.cytogfr.2007.04.007subject
Has Abstractpub_date
2007-06-01 00:00:00pages
313-25issue
3-4eissn
1359-6101issn
1879-0305pii
S1359-6101(07)00033-0journal_volume
18pub_type
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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pub_type: 杂志文章
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更新日期:2020-10-27 00:00:00
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更新日期:2006-02-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
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更新日期:2015-04-01 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:2015-10-01 00:00:00
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journal_title:Cytokine & growth factor reviews
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abstract::Interferon (IFN) induces gene expression by phosphorylating latent transcription factors of the STAT family. Two different STAT multimeric complexes that bind distinct enhancer elements are activated by IFN alpha and IFN gamma, dictated by the DNA-binding protein ISGF3 gamma p48. This protein, a member of the IFN regu...
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abstract::The role of infectious agents in the development of cancer is well documented. The pathogenesis of various human neoplasms ranging from non-Hodgkin lymphoma (NHL) to cervical carcinoma frequently involves a chronic, most often viral, infection. At the same time, there is compelling evidence that certain acute infectio...
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