Abstract：
:The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the control of T cells. However, it is now clear that TGFβ is more than an immunosuppressive cytokine. Disruption of TGFβ signaling pathway also leads to impaired generation of certain T cell populations. Therefore, in the normal physiological state, TGFβ actively maintains T cell homeostasis and regulates T cell function. However, in the tumor microenvironment, TGFβ creates an immunosuppressive milieu that inhibits antitumor immunity. Here, we review recent advances in our understanding of the roles of TGFβ in the regulation of T cells and tumor immunity.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Tu E,Chia PZ,Chen Wdoi
10.1016/j.cytogfr.2014.07.014subject
Has Abstractpub_date
2014-08-01 00:00:00pages
423-35issue
4eissn
1359-6101issn
1879-0305pii
S1359-6101(14)00076-8journal_volume
25pub_type
杂志文章,评审abstract：:Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of...
journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2013-10-01 00:00:00
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journal_title：Cytokine & growth factor reviews
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pub_type： 杂志文章,评审
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更新日期：2009-10-01 00:00:00
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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journal_title：Cytokine & growth factor reviews
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abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2003.10.002
更新日期：2004-02-01 00:00:00
