TGFβ in T cell biology and tumor immunity: Angel or devil?

Abstract:

:The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the control of T cells. However, it is now clear that TGFβ is more than an immunosuppressive cytokine. Disruption of TGFβ signaling pathway also leads to impaired generation of certain T cell populations. Therefore, in the normal physiological state, TGFβ actively maintains T cell homeostasis and regulates T cell function. However, in the tumor microenvironment, TGFβ creates an immunosuppressive milieu that inhibits antitumor immunity. Here, we review recent advances in our understanding of the roles of TGFβ in the regulation of T cells and tumor immunity.

authors

Tu E,Chia PZ,Chen W

doi

10.1016/j.cytogfr.2014.07.014

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

423-35

issue

4

eissn

1359-6101

issn

1879-0305

pii

S1359-6101(14)00076-8

journal_volume

25

pub_type

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