Abstract：
:Cancer immunotherapy using tumor-selective, oncolytic viruses is an emerging therapeutic option for solid and hematologic malignancies. A considerable variety of viruses ranging from small picornaviruses to large poxviruses are currently being investigated as potential candidates. In the early days of virotherapy, non-engineered wild-type or vaccine-strain viruses were employed. However, these viruses often did not fully satisfy the major criteria of safety and efficacy. Since the advent of reverse genetics systems for manipulating various classes of viruses, the field has shifted to developing genetically engineered viruses with an improved therapeutic index. In this review, we will summarize the concepts and strategies of multi-level genetic engineering of oncolytic measles virus, a prime candidate for cancer immunovirotherapy. Furthermore, we will provide a brief overview of measles virus-based multimodal combination therapies for improved tumor control and clinical efficacy.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Leber MF,Neault S,Jirovec E,Barkley R,Said A,Bell JC,Ungerechts Gdoi
10.1016/j.cytogfr.2020.07.005subject
Has Abstractpub_date
2020-12-01 00:00:00pages
39-48eissn
1359-6101issn
1879-0305pii
S1359-6101(20)30149-0journal_volume
56pub_type
杂志文章,评审abstract：:Normal signaling by TGFbeta, in the absence of serum or exogenous factors, involves a rapid activation of Ras, Erks, and Sapks in proliferating cultures of TGFbeta-sensitive untransformed epithelial cells and human carcinoma cells. Expression of either RasN17 or dominant-negative (DN) MKK4, or addition of the MEK1 inh...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(99)00026-x
更新日期：2000-03-01 00:00:00
abstract：:Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are imp...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.04.009
更新日期：2014-06-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe phenotype in patients suffering from mutations inactivating LIFRβ indicates that members of this cytokine family play key, non-redundant role...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.007
更新日期：2015-10-01 00:00:00
abstract：:Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in c...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章
doi：10.1016/j.cytogfr.2008.04.012
更新日期：2008-06-01 00:00:00
abstract：:Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications,...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.07.004
更新日期：2013-02-01 00:00:00
abstract：:The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.03.007
更新日期：2018-04-01 00:00:00
abstract：:Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.012
更新日期：2007-06-01 00:00:00
abstract：:The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.06.003
更新日期：2016-12-01 00:00:00
abstract：:Cytokines coordinate the activities of innate and adaptive immune systems and the Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated with the pathogenesis of chronic inflammatory diseases, ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.013
更新日期：2015-10-01 00:00:00
abstract：:Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which are ineffective, with robust diagnostic options also being limited. The prostate specific antigen (PSA) test, for instance, is su...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：:TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(99)00036-2
更新日期：2000-03-01 00:00:00
abstract：:Mutational inactivation of the p53 tumor-suppressor gene, which regulates apoptosis mainly via the cell-intrinsic pathway, reduces the sensitivity of many cancers to conventional treatments. Targeting the cell-extrinsic pathway, which triggers p53-independent apoptosis, offers a unique therapeutic strategy to induce a...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2008.04.001
更新日期：2008-06-01 00:00:00
abstract：:Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.10.001
更新日期：2010-12-01 00:00:00
abstract：:MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenil...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.12.004
更新日期：2018-02-01 00:00:00
abstract：:Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.010
更新日期：2007-06-01 00:00:00
abstract：:Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.07.003
更新日期：2006-10-01 00:00:00
abstract：:S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests t...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.01.002
更新日期：2016-12-01 00:00:00
abstract：:The coronavirus disease 19 (COVID-19) outbreak caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) had turned out to be highly pathogenic and transmittable. Researchers throughout the globe are still struggling to understand this strain's aggressiveness in search of putative therapies for its contro...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.08.002
更新日期：2020-08-25 00:00:00
abstract：:The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of thei...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2006.04.004
更新日期：2006-08-01 00:00:00
abstract：:It is conventional to identify morphogens from fly and frog embryos during morphogenesis using gene-screens, subtractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokin...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(96)00049-4
更新日期：1997-03-01 00:00:00
abstract：:In this short review, we summarize how insights into the structure and dynamics of interferon-receptor complex assembly and activation guided the design of a novel class of engineered type I interferons that combine a largely lost potency on non-targeted cells with high activity on targeted cells. These novel interfer...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.10.006
更新日期：2015-04-01 00:00:00
abstract：:Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes. Opn exists both intra- and extracellularly and in numerous pre- and post-translational isoforms. Structurally Opn resembles a matrix pr...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00055-8
更新日期：2003-12-01 00:00:00
abstract：:Despite advances in therapies that target inflammation and tissue destruction in chronic arthritis, stimulation of tissue repair and restoration of joint function, the ultimate goal of treatment, is far from achieved. We introduce a new paradigm that may help to improve our understanding and management of chronic arth...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.02.009
更新日期：2005-06-01 00:00:00
abstract：:Cellular adhesion molecules (CAMs) play an essential role in tethering circulating leukocytes to the vascular endothelium at sites of inflammation. They are also instrumental in enabling leukocytes to transmigrate from blood vessels into adjacent inflamed tissues. In the absence of signals to stimulate expression of C...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(98)00024-0
更新日期：1999-03-01 00:00:00
abstract：:Investigators from a wide variety of disciplines met at the Second National Managed Health Care Congress Meeting on chemokines held in Washington, D.C. on December 14-15, 1997, to discuss the role of chemokines in the pathogenesis of disease states, as well as a number of biological issues. Presentations on the effect...
journal_title：Cytokine & growth factor reviews
pub_type：
doi：10.1016/s1359-6101(98)00005-7
更新日期：1998-06-01 00:00:00
abstract：:Inflammation and angiogenesis are two interdependent processes underlying pathogenesis of cardiovascular disorders. The initiation and progression of atherosclerosis strongly depends on specific patterns of cytokine expression. In this review, we analyze correlation between expression of two members of the cytokine fa...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.12.001
更新日期：2018-02-01 00:00:00
abstract：:Chemotherapy remains a common mode of anticancer treatment even though in most cancer indications the therapeutic approach is not effective and ultimately associated with the onset of chemoresistance. A better understanding of genetic differences in tumors ushered in the era of targeted therapy which has revolutionize...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.02.001
更新日期：2010-04-01 00:00:00
abstract：:Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.12.001
更新日期：2011-02-01 00:00:00
abstract：:The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leadi...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(98)80005-1
更新日期：1997-12-01 00:00:00
abstract：:Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. The...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.05.004
更新日期：2020-05-18 00:00:00
