Ectodysplasin signaling in development.


:Ectodysplasin (Eda), a signaling molecule belonging to the tumor necrosis factor family, is required for normal development of several ectodermally derived organs in humans and mice. Two closely related isoforms of ectodysplasin, Eda-A1 and Eda-A2, have been described which bind to and activate two different receptors, Edar and X-linked Eda-A2 receptor (Xedar), respectively. Mutations in Eda, Edar or other molecules of this signaling pathway cause ectodermal dysplasias characterized by defective development of teeth, hairs, and several exocrine glands such as sweat glands presumably due to impaired NF-kappaB response. Studies with mice either lacking the functional proteins of Edar pathway or overexpressing the ligand or receptor suggest that Eda-A1-Edar signaling has multiple roles in ectodermal organ development regulating their initiation, morphogenesis, and differentiation.


Mikkola ML,Thesleff I




Has Abstract


2003-06-01 00:00:00














  • Cytokine adjuvants for vaccine therapy of neoplastic and infectious disease.

    abstract::Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...

    journal_title:Cytokine & growth factor reviews

    pub_type: 历史文章,杂志文章,评审


    authors: Decker WK,Safdar A

    更新日期:2011-08-01 00:00:00

  • Pharmacogenomics of Type I interferon therapy: a survey of response-modifying genes.

    abstract::Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: O'Doherty C,Villoslada P,Vandenbroeck K

    更新日期:2007-06-01 00:00:00

  • Targeting chromatin dysregulation in organ fibrosis.

    abstract::Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ f...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Rani A,Chin C,Bremner R,Mohanakumar T,Angara S

    更新日期:2020-08-30 00:00:00

  • Dual role for TGF-beta1 in apoptosis.

    abstract::The exposure of cells to TGF-beta1 can trigger a variety of cellular responses including the inhibition of cell growth, migration, differentiation and apoptosis. TGF-beta1-regulated apoptosis is cell type and context-dependent, indeed TGF-beta1 provides signals for both cell survival or apoptosis. The molecular mechan...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Sánchez-Capelo A

    更新日期:2005-02-01 00:00:00

  • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

    abstract::Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Kim HP,Imbert J,Leonard WJ

    更新日期:2006-10-01 00:00:00

  • The implication of SUMO in intrinsic and innate immunity.

    abstract::Since its discovery, SUMOylation has emerged as a key post-translational modification involved in the regulation of host-virus interactions. SUMOylation has been associated with the replication of a large number of viruses, either through the direct modification of viral proteins or through the modulation of cellular ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Hannoun Z,Maarifi G,Chelbi-Alix MK

    更新日期:2016-06-01 00:00:00

  • ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.

    abstract::Interferon (IFN) induces gene expression by phosphorylating latent transcription factors of the STAT family. Two different STAT multimeric complexes that bind distinct enhancer elements are activated by IFN alpha and IFN gamma, dictated by the DNA-binding protein ISGF3 gamma p48. This protein, a member of the IFN regu...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Bluyssen AR,Durbin JE,Levy DE

    更新日期:1996-06-01 00:00:00

  • Targeting the extrinsic apoptosis pathway in cancer.

    abstract::Mutational inactivation of the p53 tumor-suppressor gene, which regulates apoptosis mainly via the cell-intrinsic pathway, reduces the sensitivity of many cancers to conventional treatments. Targeting the cell-extrinsic pathway, which triggers p53-independent apoptosis, offers a unique therapeutic strategy to induce a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ashkenazi A

    更新日期:2008-06-01 00:00:00

  • Macrophage inflammatory protein-1.

    abstract::Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH(2)-terminal processing, one or more of the CC chemok...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Menten P,Wuyts A,Van Damme J

    更新日期:2002-12-01 00:00:00

  • The RGM/DRAGON family of BMP co-receptors.

    abstract::The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Corradini E,Babitt JL,Lin HY

    更新日期:2009-10-01 00:00:00

  • Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use.

    abstract::The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Antonelli G,Scagnolari C,Moschella F,Proietti E

    更新日期:2015-04-01 00:00:00

  • TGFβ in T cell biology and tumor immunity: Angel or devil?

    abstract::The evolutionally conserved transforming growth factor β (TGFβ) affects multiple cell types in the immune system by either stimulating or inhibiting their differentiation and function. Studies using transgenic mice with ablation of TGFβ or its receptor have revealed the biological significance of TGFβ signaling in the...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Tu E,Chia PZ,Chen W

    更新日期:2014-08-01 00:00:00

  • Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy.

    abstract::Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. W...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Tian H,Zhao J,Brochmann EJ,Wang JC,Murray SS

    更新日期:2017-04-01 00:00:00

  • Lymphocytes in cancer development: polarization towards pro-tumor immunity.

    abstract::The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ruffell B,DeNardo DG,Affara NI,Coussens LM

    更新日期:2010-02-01 00:00:00

  • Loss of Smad3 modulates wound healing.

    abstract::TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear tr...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Ashcroft GS,Roberts AB

    更新日期:2000-03-01 00:00:00

  • Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

    abstract::Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seo YJ,Alexander S,Hahm B

    更新日期:2011-02-01 00:00:00

  • Cell-autonomous and non-cell-autonomous functions of caspase-8.

    abstract::Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in c...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章


    authors: Ben Moshe T,Kang TB,Kovalenko A,Barash H,Abramovitch R,Galun E,Wallach D

    更新日期:2008-06-01 00:00:00

  • Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee.

    abstract::Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and impaired quality of life and no curative treatments exist. Increasing evidence indicates that low-grade inflammation plays a pivotal role in the onset and progression of OA. In this review, we summarize emerging findings on the...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Xie J,Huang Z,Yu X,Zhou L,Pei F

    更新日期:2019-04-01 00:00:00

  • Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

    abstract::The coronavirus disease 19 (COVID-19) outbreak caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) had turned out to be highly pathogenic and transmittable. Researchers throughout the globe are still struggling to understand this strain's aggressiveness in search of putative therapies for its contro...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Rana AK,Rahmatkar SN,Kumar A,Singh D

    更新日期:2020-08-25 00:00:00

  • The angiopoietin:Tie 2 interaction: a potential target for future therapies in human vascular disease.

    abstract::Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelial receptor tyrosine kinase Tie2. Signalling by angiopoietin-1 promotes vascular endothelial cell survival and the sprouting and reorganisation of blood vessels, as well as inhibiting activation of the vascular endothelial barrier to reduce leakage...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Moss A

    更新日期:2013-12-01 00:00:00

  • Signaling mechanisms through gp130: a model of the cytokine system.

    abstract::The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leadi...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Hirano T,Nakajima K,Hibi M

    更新日期:1997-12-01 00:00:00

  • The role of ephrins and Eph receptors in cancer.

    abstract::Eph receptors are the largest receptor tyrosine kinase family of transmembrane proteins with an extracellular domain capable of recognizing signals from the cells' environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and stimulate bi-directional signaling of th...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Surawska H,Ma PC,Salgia R

    更新日期:2004-12-01 00:00:00

  • Dually modified transmembrane proteoglycans in development and disease.

    abstract::Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Jenkins LM,Horst B,Lancaster CL,Mythreye K

    更新日期:2018-02-01 00:00:00

  • Impact of tumor microenvironment on oncolytic viral therapy.

    abstract::Interactions between tumor cells and their microenvironment have been shown to play a very significant role in the initiation, progression, and invasiveness of cancer. These tumor-stromal interactions are capable of altering the delivery and effectiveness of therapeutics into the tumor and are also known to influence ...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Wojton J,Kaur B

    更新日期:2010-04-01 00:00:00

  • Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.

    abstract::Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediat...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Mattila MM,Härkönen PL

    更新日期:2007-06-01 00:00:00

  • Nuclear import and export of proteins: the molecular basis for intracellular signaling.

    abstract::A family of latent cytoplasmic transcription factors termed Stats are activated by a variety of cytokines, and are then translocated into the nucleus where they activate transcription. Recent advances in nuclear protein import have shown that the extracellular signal-dependent nuclear import of Stat1 is mediated via c...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Sekimoto T,Yoneda Y

    更新日期:1998-09-01 00:00:00

  • Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors.

    abstract::Tumors have developed different strategies to escape immune recognition. This could be due to altered expression of classical and non-classical human leukocyte antigens (HLA), co-inhibitory or co-stimulatory molecules as well as components of the interferon signaling pathway. Furthermore, changes in the tumor microenv...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Seliger B

    更新日期:2017-08-01 00:00:00

  • The response of mammalian cells to double-stranded RNA.

    abstract::Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Gantier MP,Williams BR

    更新日期:2007-10-01 00:00:00

  • Roles of activin in tissue repair, fibrosis, and inflammatory disease.

    abstract::Activins are transforming growth factor beta superfamily members, which were originally identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, however, additional functions of activins have been discovered, including a role in the morphogenesis of various tissues and organs...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Werner S,Alzheimer C

    更新日期:2006-06-01 00:00:00

  • The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

    abstract::Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' a...

    journal_title:Cytokine & growth factor reviews

    pub_type: 杂志文章,评审


    authors: Shu C,Li X,Li P

    更新日期:2014-12-01 00:00:00