Abstract:
:Activins are transforming growth factor beta superfamily members, which were originally identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, however, additional functions of activins have been discovered, including a role in the morphogenesis of various tissues and organs. In addition, they have been identified as novel players in inflammation and repair, and are most likely involved in the pathogenesis of inflammatory and fibrotic human diseases. In this review we highlight recent data regarding the expression and function of activins in tissue repair, fibrosis, and inflammation.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Werner S,Alzheimer Cdoi
10.1016/j.cytogfr.2006.01.001subject
Has Abstractpub_date
2006-06-01 00:00:00pages
157-71issue
3eissn
1359-6101issn
1879-0305pii
S1359-6101(06)00003-7journal_volume
17pub_type
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2016.01.002
更新日期:2016-12-01 00:00:00
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
doi:10.1016/j.cytogfr.2019.03.002
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journal_title:Cytokine & growth factor reviews
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doi:10.1016/j.cytogfr.2020.08.002
更新日期:2020-08-25 00:00:00
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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doi:10.1016/s1359-6101(03)00003-0
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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doi:10.1016/j.cytogfr.2010.12.001
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journal_title:Cytokine & growth factor reviews
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journal_title:Cytokine & growth factor reviews
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abstract::Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal o...
journal_title:Cytokine & growth factor reviews
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abstract::Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. The...
journal_title:Cytokine & growth factor reviews
pub_type: 杂志文章,评审
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abstract::Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...
journal_title:Cytokine & growth factor reviews
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