Abstract：
:Vascular endothelial growth factor (VEGF) is a key growth factor driving angiogenesis (i.e. the formation of new blood vessels) in health and disease. Pharmacological blockade of VEGF signaling to inhibit tumor angiogenesis is clinically approved but the survival benefit is limited as patients invariably acquire resistance. This is partially mediated by the intrinsic flexibility of tumor cells to adapt to VEGF-blockade. However, it has become clear that tumor stromal cells also contribute to the resistance. Originally, VEGF was thought to specifically target endothelial cells (ECs) but it is now clear that many stromal cells also respond to VEGF signaling, making anti-VEGF therapy more complex than initially anticipated. A more comprehensive understanding of the complex responses of stromal cells to VEGF-blockade might inform the design of improved anti-angiogenic agents.
journal_name
Cytokine Growth Factor Revjournal_title
Cytokine & growth factor reviewsauthors
Moens S,Goveia J,Stapor PC,Cantelmo AR,Carmeliet Pdoi
10.1016/j.cytogfr.2014.07.009subject
Has Abstractpub_date
2014-08-01 00:00:00pages
473-82issue
4eissn
1359-6101issn
1879-0305pii
S1359-6101(14)00071-9journal_volume
25pub_type
杂志文章,评审abstract：:The induction of hundreds of Interferon Stimulated Genes (ISGs) subsequent to virus infection generates an antiviral state that functions to restrict virus growth at multiple steps of their replication cycles. In the context of Human Immunodeficiency Virus-1 (HIV-1), ISGs also possess antiviral functions, but some ISG...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.03.007
更新日期：2018-04-01 00:00:00
abstract：:Eph receptors are the largest receptor tyrosine kinase family of transmembrane proteins with an extracellular domain capable of recognizing signals from the cells' environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and stimulate bi-directional signaling of th...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2004.09.002
更新日期：2004-12-01 00:00:00
abstract：:The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike other growth factors, FGFs act in concert with heparin...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2005.01.001
更新日期：2005-04-01 00:00:00
abstract：:Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular prolifera...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.05.002
更新日期：2010-08-01 00:00:00
abstract：:Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin an...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.08.003
更新日期：2012-12-01 00:00:00
abstract：:Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.10.001
更新日期：2010-12-01 00:00:00
abstract：:The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.06.003
更新日期：2016-12-01 00:00:00
abstract：:Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vacci...
journal_title：Cytokine & growth factor reviews
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.cytogfr.2011.07.001
更新日期：2011-08-01 00:00:00
abstract：:The cyclins are a family of proteins that are centrally involved in cell cycle regulation and which are structurally identified by conserved "cyclin box" regions. They are regulatory subunits of holoenzyme cyclin-dependent kinase (CDK) complexes controlling progression through cell cycle checkpoints by phosphorylating...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(00)00018-6
更新日期：2001-03-01 00:00:00
abstract：:The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leadi...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(98)80005-1
更新日期：1997-12-01 00:00:00
abstract：:Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal o...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.10.001
更新日期：2013-04-01 00:00:00
abstract：:MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2011.05.002
更新日期：2011-06-01 00:00:00
abstract：:Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respect...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2015.07.006
更新日期：2015-10-01 00:00:00
abstract：:Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes. Opn exists both intra- and extracellularly and in numerous pre- and post-translational isoforms. Structurally Opn resembles a matrix pr...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00055-8
更新日期：2003-12-01 00:00:00
abstract：:Chemotherapy remains a common mode of anticancer treatment even though in most cancer indications the therapeutic approach is not effective and ultimately associated with the onset of chemoresistance. A better understanding of genetic differences in tumors ushered in the era of targeted therapy which has revolutionize...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2010.02.001
更新日期：2010-04-01 00:00:00
abstract：:Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) is one of several members of the TNF gene superfamily that induce apoptosis through engagement of death receptors. Apo2L/TRAIL is unusual as compared to any other cytokine as it interacts with a complex system of receptors: two ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00029-7
更新日期：2003-06-01 00:00:00
abstract：:Ectodysplasin (Eda), a signaling molecule belonging to the tumor necrosis factor family, is required for normal development of several ectodermally derived organs in humans and mice. Two closely related isoforms of ectodysplasin, Eda-A1 and Eda-A2, have been described which bind to and activate two different receptors...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(03)00020-0
更新日期：2003-06-01 00:00:00
abstract：:It is conventional to identify morphogens from fly and frog embryos during morphogenesis using gene-screens, subtractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokin...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/s1359-6101(96)00049-4
更新日期：1997-03-01 00:00:00
abstract：:Dendritic cells (DCs) are powerful sensors of foreign pathogens as well as cancer cells and provide the first line of defence against infection. They also serve as a major link between innate and adaptive immunity. Immature DCs respond to incoming danger signals and undergo maturation to produce high levels of proinfl...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.06.008
更新日期：2007-10-01 00:00:00
abstract：:Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2016.06.002
更新日期：2016-12-01 00:00:00
abstract：:Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild sy...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.04.002
更新日期：2020-06-01 00:00:00
abstract：:The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian con...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2013.03.005
更新日期：2013-06-01 00:00:00
abstract：:Interferon-beta (IFN-beta) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highli...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2007.04.012
更新日期：2007-06-01 00:00:00
abstract：:In this short review, we summarize how insights into the structure and dynamics of interferon-receptor complex assembly and activation guided the design of a novel class of engineered type I interferons that combine a largely lost potency on non-targeted cells with high activity on targeted cells. These novel interfer...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.10.006
更新日期：2015-04-01 00:00:00
abstract：:The main contribution of this article is to report general statistics about COVID-19 in Brazil, based on analysis of accumulated series of confirmed cases, deaths and lethality rates, in addition to presenting graphs of moving averages for states and municipalities. The data show that the pandemic in Brazil has grown ...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2020.10.010
更新日期：2020-11-05 00:00:00
abstract：:Interferon (IFN) induces gene expression by phosphorylating latent transcription factors of the STAT family. Two different STAT multimeric complexes that bind distinct enhancer elements are activated by IFN alpha and IFN gamma, dictated by the DNA-binding protein ISGF3 gamma p48. This protein, a member of the IFN regu...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/1359-6101(96)00005-6
更新日期：1996-06-01 00:00:00
abstract：:Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the inn...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2014.12.006
更新日期：2015-04-01 00:00:00
abstract：:Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which are ineffective, with robust diagnostic options also being limited. The prostate specific antigen (PSA) test, for instance, is su...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2012.04.004
更新日期：2012-06-01 00:00:00
abstract：:Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular carcinoma) represent one of the most common causes of death worldwide. A number of genetic and environmental factors contribute to the development of liver diseases. Interleukin-6 (IL-6) is a pleiotropic cytokine, exerting var...
journal_title：Cytokine & growth factor reviews
pub_type： 杂志文章,评审
doi：10.1016/j.cytogfr.2018.01.002
更新日期：2018-02-01 00:00:00
