解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The genus Claviceps has been known for centuries as an economically important fungal genera for pharmacology and agricultural research. Only recently have researchers begun to unravel the evolutionary history of the genus, with origins in South America and classification of four distinct sections through ecological, m...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa267
更新日期:2021-01-29 00:00:00
abstract::Gene duplications and novel genes have been shown to play a major role in helminth adaptation to a parasitic lifestyle because they provide the novelty necessary for adaptation to a changing environment, such as living in multiple hosts. Here we present the de novo sequenced and annotated genome of the parasitic trema...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evab010
更新日期:2021-01-23 00:00:00
abstract::Comparative genome analyses have suggested East Asia to be the cradle of the domesticated microbe Brewer's yeast (Saccharomyces cerevisiae), used in the food and biotechnology industry worldwide. Here, we provide seven new, high quality long read genomes of non-domesticated yeast strains isolated from primeval forests...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evab001
更新日期:2021-01-11 00:00:00
abstract::Cytoplasmic male sterility (MS) in plants is caused by MS-inducing mitochondria, which have emerged frequently during plant evolution. Nuclear restorer-of-fertility (Rf)genes can suppress their cognate MS-inducing mitochondria. Whereas many Rfs encode a class of RNA-binding protein, the sugar beet (Caryophyllales) Rf ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa186
更新日期:2020-12-06 00:00:00
abstract::North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa207
更新日期:2020-12-06 00:00:00
abstract::Rhizobia are soil bacteria capable of forming symbiotic nitrogen-fixing nodules associated with leguminous plants. In fast-growing legume-nodulating rhizobia, such as the species in the family Rhizobiaceae, the symbiotic plasmid is the main genetic basis for nitrogen-fixing symbiosis, and is susceptible to horizontal ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa152
更新日期:2020-11-03 00:00:00
abstract::Retrotransposons, DNA sequences capable of creating copies of themselves, compose about half of the human genome and played a central role in the evolution of mammals. Their current position in the host genome is the result of the retrotranscription process and of the following host genome evolution. We apply a model ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa201
更新日期:2020-11-03 00:00:00
abstract::Bacteria of the Planctomycetes phylum have many unique cellular features, such as extensive membrane invaginations and the ability to import macromolecules. These features raise intriguing questions about the composition of their cell envelopes. In this study, we have used microscopy, phylogenomics, and proteomics to ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa159
更新日期:2020-09-01 00:00:00
abstract::The precise localization of CaV2 voltage-gated calcium channels at the synapse active zone requires various interacting proteins, of which, Rab3-interacting molecule or RIM is considered particularly important. In vertebrates, RIM interacts with CaV2 channels in vitro via a PDZ domain that binds to the extreme C-termi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa097
更新日期:2020-08-01 00:00:00
abstract::Experimental evolution allows the observation of change over time as laboratory populations evolve in response to novel, controlled environments. Microbial evolution experiments take advantage of cryopreservation to archive experimental populations in glycerol media, creating a frozen, living "fossil" record. Prior re...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa121
更新日期:2020-08-01 00:00:00
abstract::In 1957, an invasive and highly defensive honey bee began to spread across Brazil. In the previous year, Brazilian researchers hoped to produce a subtropical-adapted honey bee by crossing local commercial honey bees (of European origin) with a South African honey bee subspecies (Apis mellifera scutellata; an A-lineage...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa128
更新日期:2020-08-01 00:00:00
abstract::Although the human Y chromosome has effectively shown utility in uncovering facets of human evolution and population histories, the ascertainment bias present in early Y-chromosome variant data sets limited the accuracy of diversity and TMRCA estimates obtained from them. The advent of next-generation sequencing, howe...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa098
更新日期:2020-07-01 00:00:00
abstract::Glycosaminoglycans are sulfated polysaccharide molecules, essential for many biological processes. The 6-O sulfation of glycosaminoglycans is carried out by carbohydrate 6-O sulfotransferases (C6OSTs), previously named Gal/GalNAc/GlcNAc 6-O sulfotransferases. Here, for the first time, we present a detailed phylogeneti...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz274
更新日期:2020-07-01 00:00:00
abstract::Plant mitochondrial genomes vary widely in size. Although many plant mitochondrial genomes have been sequenced and assembled, the vast majority are of angiosperms, and few are of gymnosperms. Most plant mitochondrial genomes are smaller than a megabase, with a few notable exceptions. We have sequenced and assembled th...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa108
更新日期:2020-07-01 00:00:00
abstract::Nematodes are highly abundant animals with diverse habitats and lifestyles. Some are free living whereas others parasitize animals or plants, and among the latter, infection abilities change across developmental stages to infect hosts and complete life cycles. To determine the relationship between transcriptome evolut...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa110
更新日期:2020-07-01 00:00:00
abstract::Multicopy ampliconic gene families on the Y chromosome play an important role in spermatogenesis. Thus, studying their genetic variation in endangered great ape species is critical. We estimated the sizes (copy number) of nine Y ampliconic gene families in population samples of chimpanzee, bonobo, and orangutan with d...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa088
更新日期:2020-06-01 00:00:00
abstract::Biodegradation of the phenylurea herbicide linuron appears a specialization within a specific clade of the Variovorax genus. The linuron catabolic ability is likely acquired by horizontal gene transfer but the mechanisms involved are not known. The full-genome sequences of six linuron-degrading Variovorax strains isol...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa085
更新日期:2020-06-01 00:00:00
abstract::Genomic analysis of many nonmodel species has uncovered an incredible diversity of sex chromosome systems, making it possible to empirically test the rich body of evolutionary theory that describes each stage of sex chromosome evolution. Classic theory predicts that sex chromosomes originate from a pair of homologous ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa081
更新日期:2020-06-01 00:00:00
abstract::piRNA clusters are thought to repress transposable element (TE) activity in mammals and invertebrates. Here, we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: The total size of the piRNA clusters of an organism must exceed 0.2% of a genome to repress TE invasions. More...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa064
更新日期:2020-05-01 00:00:00
abstract::Animals interact with a diverse array of both beneficial and detrimental microorganisms. In insects, these symbioses in many cases allow feeding on nutritionally unbalanced diets. It is, however, still not clear how are obligate symbioses maintained at the cellular level for up to several hundred million years. Exact ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa032
更新日期:2020-04-01 00:00:00
abstract::The ability to obtain genome-wide sequences of very large numbers of individuals from natural populations raises questions about optimal sampling designs and the limits to extracting information on key population-genetic parameters from temporal-survey data. Methods are introduced for evaluating whether observed tempo...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa056
更新日期:2020-04-01 00:00:00
abstract::Colonization of new habitats often reduces population sizes and may result in the accumulation of deleterious mutations by genetic drift. Compared with the genomic basis for adaptation to new environments, genome-wide analysis of deleterious mutations in isolated populations remains limited. In the present study, we i...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa065
更新日期:2020-04-01 00:00:00
abstract::Horizontal gene transfer is a common mechanism in Bacteria that has contributed to the genomic content of existing organisms. Traditional methods for estimating bacterial phylogeny, however, assume only vertical inheritance in the evolution of homologous genes, which may result in errors in the estimated phylogenies. ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa058
更新日期:2020-04-01 00:00:00
abstract::Positive selection and purifying selection reduce levels of variation at linked neutral loci. One consequence of these processes is that the amount of neutral diversity and the meiotic recombination rate are predicted to be positively correlated across the genome-a prediction met in some species but not others. To bet...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evaa045
更新日期:2020-04-01 00:00:00
abstract::Sex chromosomes contribute substantially to key evolutionary processes such as speciation and adaptation. Several theories suggest that evolution could occur more rapidly on sex chromosomes, but currently our understanding of whether and how this occurs is limited. Here, we present an analysis of the great tit (Parus ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa044
更新日期:2020-03-01 00:00:00
abstract::Wolbachia is a widely distributed intracellular bacterial endosymbiont among invertebrates. The wStriCN, the Wolbachia strain that naturally infects an agricultural pest Laodelphax striatellus, has a "Jekyll and Hyde" mode of infection pattern with positive and negative effects: It not only kills many offspring by ind...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa006
更新日期:2020-02-01 00:00:00
abstract::The Asian honey bee (Apis dorsata) is distinct from its more widely distributed cousin Apis mellifera by a few key characteristics. Most prominently, A. dorsata, nest in the open by forming a colony clustered around the honeycomb, whereas A. mellifera nest in concealed cavities. Additionally, the worker and reproducti...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz277
更新日期:2020-01-01 00:00:00
abstract::The common pheasant (Phasianus colchicus) in the order Galliformes and the family Phasianidae, has 30 subspecies distributed across its native range in the Palearctic realm and has been introduced to Europe, North America, and Australia. It is an important game bird often subjected to wildlife management as well as a ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz249
更新日期:2019-12-01 00:00:00
abstract::Clashes between transcription and replication complexes can cause point mutations and chromosome rearrangements on heavily transcribed genes. In eukaryotic ribosomal RNA genes, the system that prevents transcription-replication conflicts also causes frequent copy number variation. Such fast mutational dynamics do not ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz235
更新日期:2019-11-01 00:00:00
abstract::RNA editing occurs in the organellar mRNAs of all land plants but the marchantioid liverworts, making liverworts a perfect group for studying the evolution of RNA editing. Here, we profiled the RNA editing of 42 exemplars spanning the ordinal phylogenetic diversity of liverworts, and screened for the nuclear-encoded p...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz232
更新日期:2019-11-01 00:00:00
abstract::To fulfill their physiological functions, bile acids are conjugated with amino acids. In humans, conjugation is catalyzed by bile acid coenzyme A: amino acid N-acyltransferase (BAAT), an enzyme with a highly conserved catalytic triad in its active site. Interestingly, the conjugated amino acids are highly variable amo...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz238
更新日期:2019-11-01 00:00:00
abstract::Population bottlenecks leading to a drastic reduction of the population size are common in the evolutionary dynamics of natural populations; their occurrence is known to have implications for genome evolution due to genetic drift, the consequent reduction in genetic diversity, and the rate of adaptation. Nevertheless,...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz243
更新日期:2019-11-01 00:00:00
abstract::A long-standing mystery of genomic/transcriptomic structure involves spliced leader trans-splicing (SLTS), in which short RNA "tags" transcribed from a distinct genomic locus is added near the 5' end of RNA transcripts by the spliceosome. SLTS has been observed in diverse eukaryotes in a phylogenetic pattern implying ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz217
更新日期:2019-10-01 00:00:00
abstract::In this study, the full genome sequence of Bacillus velezensis strain UFLA258, a biological control agent of plant pathogens was obtained, assembled, and annotated. With a comparative genomics approach, in silico analyses of all complete genomes of B. velezensis and closely related species available in the database we...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz208
更新日期:2019-10-01 00:00:00
abstract::Parasitoid wasps are among the most speciose animals, yet have relatively few available genomic resources. We report a draft genome assembly of the wasp Diachasma alloeum (Hymenoptera: Braconidae), a host-specific parasitoid of the apple maggot fly Rhagoletis pomonella (Diptera: Tephritidae), and a developing model fo...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz205
更新日期:2019-10-01 00:00:00
abstract::Immunity genes have repeatedly experienced natural selection during mammalian evolution. Galectins are carbohydrate-binding proteins that regulate diverse immune responses, including maternal-fetal immune tolerance in placental pregnancy. Seven human galectins, four conserved across vertebrates and three specific to p...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz183
更新日期:2019-09-01 00:00:00
abstract::Explaining the evolution of animals requires ecological, developmental, paleontological, and phylogenetic considerations because organismal traits are affected by complex evolutionary processes. Modeling a plurality of processes, operating at distinct time-scales on potentially interdependent traits, can benefit from ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz182
更新日期:2019-09-01 00:00:00
abstract::Chagas disease was described by Carlos Chagas, who first identified the parasite Trypanosoma cruzi from a 2-year-old girl called Berenice. Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream comparative analyses are extremely challenging in this species, given t...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz129
更新日期:2019-07-01 00:00:00
abstract::Over 40 species of nonhuman primates host simian immunodeficiency viruses (SIVs). In natural hosts, infection is generally assumed to be nonpathogenic due to a long coevolutionary history between host and virus, although pathogenicity is difficult to study in wild nonhuman primates. We used whole-blood RNA-seq and SIV...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz099
更新日期:2019-06-01 00:00:00
abstract::The genus Halomonas possesses bacteria that are halophilic or halotolerant and exhibit a wide range of pH tolerance. The genome of Halomonas sp. Soap Lake #7 was sequenced to provide a better understanding of the mechanisms for salt and pH tolerance in this genus. The bacterium's genome was found to possess two comple...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz117
更新日期:2019-06-01 00:00:00