Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.

Abstract:

:North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of ∼2.2 million genome-wide single nucleotide polymorphisms. As a result, an ∼13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1-BTNL2-HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB populations and is estimated to have arisen ∼5.5 thousand years (∼220 generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment.

journal_name

Genome Biol Evol

authors

Hoh BP,Zhang X,Deng L,Yuan K,Yew CW,Saw WY,Hoque MZ,Aghakhanian F,Phipps ME,Teo YY,Subbiah VK,Xu S

doi

10.1093/gbe/evaa207

subject

Has Abstract

pub_date

2020-12-06 00:00:00

pages

2245-2257

issue

12

issn

1759-6653

pii

5918456

journal_volume

12

pub_type

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