Abstract:
:North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of ∼2.2 million genome-wide single nucleotide polymorphisms. As a result, an ∼13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1-BTNL2-HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB populations and is estimated to have arisen ∼5.5 thousand years (∼220 generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment.
journal_name
Genome Biol Evoljournal_title
Genome biology and evolutionauthors
Hoh BP,Zhang X,Deng L,Yuan K,Yew CW,Saw WY,Hoque MZ,Aghakhanian F,Phipps ME,Teo YY,Subbiah VK,Xu Sdoi
10.1093/gbe/evaa207subject
Has Abstractpub_date
2020-12-06 00:00:00pages
2245-2257issue
12issn
1759-6653pii
5918456journal_volume
12pub_type
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