The Limits to Estimating Population-Genetic Parameters with Temporal Data.

Abstract:

:The ability to obtain genome-wide sequences of very large numbers of individuals from natural populations raises questions about optimal sampling designs and the limits to extracting information on key population-genetic parameters from temporal-survey data. Methods are introduced for evaluating whether observed temporal fluctuations in allele frequencies are consistent with the hypothesis of random genetic drift, and expressions for the expected sampling variances for the relevant statistics are given in terms of sample sizes and numbers. Estimation methods and aspects of statistical reliability are also presented for the mean and temporal variance of selection coefficients. For nucleotide sites that pass the test of neutrality, the current effective population size can be estimated by a method of moments, and expressions for its sampling variance provide insight into the degree to which such methodology can yield meaningful results under alternative sampling schemes. Finally, some caveats are raised regarding the use of the temporal covariance of allele-frequency change to infer selection. Taken together, these results provide a statistical view of the limits to population-genetic inference in even the simplest case of a closed population.

journal_name

Genome Biol Evol

authors

Lynch M,Ho WC

doi

10.1093/gbe/evaa056

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

443-455

issue

4

issn

1759-6653

pii

5809145

journal_volume

12

pub_type

杂志文章
  • Defense Response in Brazilian Honey Bees (Apis mellifera scutellata × spp.) Is Underpinned by Complex Patterns of Admixture.

    abstract::In 1957, an invasive and highly defensive honey bee began to spread across Brazil. In the previous year, Brazilian researchers hoped to produce a subtropical-adapted honey bee by crossing local commercial honey bees (of European origin) with a South African honey bee subspecies (Apis mellifera scutellata; an A-lineage...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evaa128

    authors: Harpur BA,Kadri SM,Orsi RO,Whitfield CW,Zayed A

    更新日期:2020-08-01 00:00:00

  • Lineage-Specific Expression Divergence in Grasses Is Associated with Male Reproduction, Host-Pathogen Defense, and Domestication.

    abstract::Poaceae (grasses) is an agriculturally important and widely distributed family of plants with extraordinary phenotypic diversity, much of which was generated under recent lineage-specific evolution. Yet, little is known about the genes and functional modules involved in the lineage-specific divergence of grasses. Here...

    journal_title:Genome biology and evolution

    pub_type: 信件

    doi:10.1093/gbe/evy245

    authors: Assis R

    更新日期:2019-01-01 00:00:00

  • The Role of microRNAs in the Repeated Parallel Diversification of Lineages of Midas Cichlid Fish from Nicaragua.

    abstract::Cichlid fishes are an ideal model system for studying biological diversification because they provide textbook examples of rapid speciation. To date, there has been little focus on the role of gene regulation during cichlid speciation. However, in recent years, gene regulation has been recognized as a powerful force l...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evw097

    authors: Franchini P,Xiong P,Fruciano C,Meyer A

    更新日期:2016-06-03 00:00:00

  • Organellar Genomes from a ∼5,000-Year-Old Archaeological Maize Sample Are Closely Related to NB Genotype.

    abstract::The story of how preColumbian civilizations developed goes hand-in-hand with the process of plant domestication by Mesoamerican inhabitants. Here, we present the almost complete sequence of a mitochondrial genome and a partial chloroplast genome from an archaeological maize sample collected at the Valley of Tehuacán, ...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evx048

    authors: Pérez-Zamorano B,Vallebueno-Estrada M,Martínez González J,García Cook A,Montiel R,Vielle-Calzada JP,Delaye L

    更新日期:2017-04-01 00:00:00

  • Scanning for the signatures of positive selection for human-specific insertions and deletions.

    abstract::Human-specific small insertions and deletions (HS indels, with lengths <100 bp) are reported to be ubiquitous in the human genome. However, whether these indels contribute to human-specific traits remains unclear. Here we employ a modified McDonald-Kreitman (MK) test and a combinatorial population genetics approach to...

    journal_title:Genome biology and evolution

    pub_type: 信件

    doi:10.1093/gbe/evp041

    authors: Chen CH,Chuang TJ,Liao BY,Chen FC

    更新日期:2009-10-20 00:00:00

  • Spatial dynamics of evolving dosage compensation in a young sex chromosome system.

    abstract::The loss of Y-linked genes during sex chromosome evolution creates a potentially deleterious low gene dosage in males. Recent studies have reported different strategies of dosage compensation. Unfortunately, most of these studies investigated taxa with comparatively old sex chromosome systems, which may limit insights...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evv013

    authors: Schultheiß R,Viitaniemi HM,Leder EH

    更新日期:2015-01-23 00:00:00

  • Being Aquifex aeolicus: Untangling a hyperthermophile's checkered past.

    abstract::Lateral gene transfer (LGT) is an important factor contributing to the evolution of prokaryotic genomes. The Aquificae are a hyperthermophilic bacterial group whose genes show affiliations to many other lineages, including the hyperthermophilic Thermotogae, the Proteobacteria, and the Archaea. Previous phylogenomic an...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evt195

    authors: Eveleigh RJ,Meehan CJ,Archibald JM,Beiko RG

    更新日期:2013-01-01 00:00:00

  • Dynamics of gene duplication in the genomes of chlorophyll d-producing cyanobacteria: implications for the ecological niche.

    abstract::Gene duplication may be an important mechanism for the evolution of new functions and for the adaptive modulation of gene expression via dosage effects. Here, we analyzed the fate of gene duplicates for two strains of a novel group of cyanobacteria (genus Acaryochloris) that produces the far-red light absorbing chloro...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evr060

    authors: Miller SR,Wood AM,Blankenship RE,Kim M,Ferriera S

    更新日期:2011-01-01 00:00:00

  • The repABC Plasmids with Quorum-Regulated Transfer Systems in Members of the Rhizobiales Divide into Two Structurally and Separately Evolving Groups.

    abstract::The large repABC plasmids of the order Rhizobiales with Class I quorum-regulated conjugative transfer systems often define the nature of the bacterium that harbors them. These otherwise diverse plasmids contain a core of highly conserved genes for replication and conjugation raising the question of their evolutionary ...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evv227

    authors: Wetzel ME,Olsen GJ,Chakravartty V,Farrand SK

    更新日期:2015-11-19 00:00:00

  • Global Rate Variation in Bony Vertebrates.

    abstract::This study investigated long-term substitution rate differences using three calibration points, divergences between lobe-finned vertebrates and ray-finned fish, between mammals and sauropsids, and between holosteans (gar and bowfin) and teleost fish with amino acid sequence data of 625 genes for 25 bony vertebrates. T...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evy125

    authors: Takezaki N

    更新日期:2018-07-01 00:00:00

  • High Levels of Copy Number Variation of Ampliconic Genes across Major Human Y Haplogroups.

    abstract::Because of its highly repetitive nature, the human male-specific Y chromosome remains understudied. It is important to investigate variation on the Y chromosome to understand its evolution and contribution to phenotypic variation, including infertility. Approximately 20% of the human Y chromosome consists of ampliconi...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evy086

    authors: Ye D,Zaidi AA,Tomaszkiewicz M,Anthony K,Liebowitz C,DeGiorgio M,Shriver MD,Makova KD

    更新日期:2018-05-01 00:00:00

  • Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba.

    abstract::Amoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Although the primary etiological agent of amoebiasis is the obligate human parasite Entamoeba histolytica, other members of the genus Entamoeba can infect humans and may be pathogenic. Here, we present the first annotated refere...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evz009

    authors: Wilson IW,Weedall GD,Lorenzi H,Howcroft T,Hon CC,Deloger M,Guillén N,Paterson S,Clark CG,Hall N

    更新日期:2019-03-01 00:00:00

  • The mitochondrial genome of the glomeromycete Rhizophagus sp. DAOM 213198 reveals an unusual organization consisting of two circular chromosomes.

    abstract::Mitochondrial (mt) genomes are intensively studied in Ascomycota and Basidiomycota, but they are poorly documented in basal fungal lineages. In this study, we sequenced the complete mtDNA of Rhizophagus sp. DAOM 213198, a close relative to Rhizophagus irregularis, a widespread, ecologically and economical relevant spe...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evu268

    authors: Nadimi M,Stefani FO,Hijri M

    更新日期:2014-12-19 00:00:00

  • Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution.

    abstract::The process of transcription is highly stochastic leading to cell-to-cell variations and noise in gene expression levels. However, key essential genes have to be precisely expressed at the correct amount and time to ensure proper cellular development and function. Studies in yeast and bacterial systems have shown that...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evv179

    authors: Vance KW,Woodcock DJ,Reid JE,Bretschneider T,Ott S,Koentges G

    更新日期:2015-09-04 00:00:00

  • A model for the effect of homologous recombination on microbial diversification.

    abstract::The effect of homologous recombination (HR) on the evolution of microbial genomes remains contentious as competing hypotheses seek to explain the evolutionary dynamics of microbial species. Evidence for HR between microbial genomes is widespread, and this process has been proposed to act as a cohesive force that can c...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evr110

    authors: Doroghazi JR,Buckley DH

    更新日期:2011-01-01 00:00:00

  • Developmental Progression in the Coral Acropora digitifera Is Controlled by Differential Expression of Distinct Regulatory Gene Networks.

    abstract::Corals belong to the most basal class of the Phylum Cnidaria, which is considered the sister group of bilaterian animals, and thus have become an emerging model to study the evolution of developmental mechanisms. Although cell renewal, differentiation, and maintenance of pluripotency are cellular events shared by mult...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evw042

    authors: Reyes-Bermudez A,Villar-Briones A,Ramirez-Portilla C,Hidaka M,Mikheyev AS

    更新日期:2016-03-23 00:00:00

  • Evolution of a bitter taste receptor gene cluster in a New World sparrow.

    abstract::Bitter taste perception likely evolved as a protective mechanism against the ingestion of harmful compounds in food. The evolution of the taste receptor type 2 (TAS2R) gene family, which encodes the chemoreceptors that are directly responsible for the detection of bitter compounds, has therefore been of considerable i...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evq027

    authors: Davis JK,Lowman JJ,Thomas PJ,ten Hallers BF,Koriabine M,Huynh LY,Maney DL,de Jong PJ,Martin CL,NISC Comparative Sequencing Program.,Thomas JW

    更新日期:2010-07-12 00:00:00

  • Whole-Genome Analysis of Halomonas sp. Soap Lake #7 Reveals It Possesses Putative Mrp Antiporter Operon Groups 1 and 2.

    abstract::The genus Halomonas possesses bacteria that are halophilic or halotolerant and exhibit a wide range of pH tolerance. The genome of Halomonas sp. Soap Lake #7 was sequenced to provide a better understanding of the mechanisms for salt and pH tolerance in this genus. The bacterium's genome was found to possess two comple...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evz117

    authors: Mormile MR,Edwards T,Frank R,Geurin Z,Haendiges J,Hoffmann M,Miller J

    更新日期:2019-06-01 00:00:00

  • Comparative Phylogenomic Assessment of Mitochondrial Introgression among Several Species of Chipmunks (Tamias).

    abstract::Many species are not completely reproductively isolated, resulting in hybridization and genetic introgression. Organellar genomes, such as those derived from mitochondria (mtDNA) and chloroplasts, introgress frequently in natural systems; however, the forces shaping patterns of introgression are not always clear. Here...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evw254

    authors: Sarver BA,Demboski JR,Good JM,Forshee N,Hunter SS,Sullivan J

    更新日期:2017-01-01 00:00:00

  • Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis.

    abstract::Acquisition of Elizabethkingia infections in intensive care units (ICUs) has risen in the past decade. Treatment of Elizabethkingia infections is challenging due to the lack of effective therapeutic regimens, leading to a high mortality rate. Elizabethkingia infections have long been attributed to Elizabethkingia meni...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evu094

    authors: Teo J,Tan SY,Liu Y,Tay M,Ding Y,Li Y,Kjelleberg S,Givskov M,Lin RT,Yang L

    更新日期:2014-05-06 00:00:00

  • Multispecies coalescent analysis of the early diversification of neotropical primates: phylogenetic inference under strong gene trees/species tree conflict.

    abstract::Neotropical primates (NP) are presently distributed in the New World from Mexico to northern Argentina, comprising three large families, Cebidae, Atelidae, and Pitheciidae, consequently to their diversification following their separation from Old World anthropoids near the Eocene/Oligocene boundary, some 40 Ma. The ev...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evu244

    authors: Schrago CG,Menezes AN,Furtado C,Bonvicino CR,Seuanez HN

    更新日期:2014-11-05 00:00:00

  • Assortment of Flowering Time and Immunity Alleles in Natural Arabidopsis thaliana Populations Suggests Immunity and Vegetative Lifespan Strategies Coevolve.

    abstract::The selective impact of pathogen epidemics on host defenses can be strong but remains transient. By contrast, life-history shifts can durably and continuously modify the balance between costs and benefits of immunity, which arbitrates the evolution of host defenses. Their impact on the evolutionary dynamics of host im...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evy124

    authors: Glander S,He F,Schmitz G,Witten A,Telschow A,de Meaux J

    更新日期:2018-09-01 00:00:00

  • The microevolution of V1r vomeronasal receptor genes in mice.

    abstract::Vomeronasal sensitivity is important for detecting intraspecific pheromonal cues as well as environmental odorants and is involved in mating, social interaction, and other daily activities of many vertebrates. Two large families of seven-transmembrane G-protein-coupled receptors, V1rs and V2rs, bind to various ligands...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evr039

    authors: Park SH,Podlaha O,Grus WE,Zhang J

    更新日期:2011-01-01 00:00:00

  • Comprehensive Genomic Analysis and Expression Profiling of the NOX Gene Families under Abiotic Stresses and Hormones in Plants.

    abstract::Plasma membrane NADPH oxidases (NOXs) are key producers of reactive oxygen species under both normal and stress conditions in plants and they form functional subfamilies. Studies of these subfamilies indicated that they show considerable evolutionary selection. We performed a comparative genomic analysis that identifi...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evw035

    authors: Chang YL,Li WY,Miao H,Yang SQ,Li R,Wang X,Li WQ,Chen KM

    更新日期:2016-02-23 00:00:00

  • Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates.

    abstract::The adaptive significance of human brain evolution has been frequently studied through comparisons with other primates. However, the evolution of increased brain size is not restricted to the human lineage but is a general characteristic of primate evolution. Whether or not these independent episodes of increased brai...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evx028

    authors: Boddy AM,Harrison PW,Montgomery SH,Caravas JA,Raghanti MA,Phillips KA,Mundy NI,Wildman DE

    更新日期:2017-03-01 00:00:00

  • Developmental Constraints on Genome Evolution in Four Bilaterian Model Species.

    abstract::Developmental constraints on genome evolution have been suggested to follow either an early conservation model or an "hourglass" model. Both models agree that late development strongly diverges between species, but debate on which developmental period is the most conserved. Here, based on a modified "Transcriptome Age...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evy177

    authors: Liu J,Robinson-Rechavi M

    更新日期:2018-09-01 00:00:00

  • Transcriptional Mutagenesis Prevents Ribosomal DNA Deterioration: The Role of Duplications and Deletions.

    abstract::Clashes between transcription and replication complexes can cause point mutations and chromosome rearrangements on heavily transcribed genes. In eukaryotic ribosomal RNA genes, the system that prevents transcription-replication conflicts also causes frequent copy number variation. Such fast mutational dynamics do not ...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evz235

    authors: Colizzi ES,Hogeweg P

    更新日期:2019-11-01 00:00:00

  • Population Genomic Analysis of a Pitviper Reveals Microevolutionary Forces Underlying Venom Chemistry.

    abstract::Venoms are among the most biologically active secretions known, and are commonly believed to evolve under extreme positive selection. Many venom gene families, however, have undergone duplication, and are often deployed in doses vastly exceeding the LD50 for most prey species, which should reduce the strength of posit...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evx199

    authors: Aird SD,Arora J,Barua A,Qiu L,Terada K,Mikheyev AS

    更新日期:2017-10-01 00:00:00

  • Early Metazoan Origin and Multiple Losses of a Novel Clade of RIM Presynaptic Calcium Channel Scaffolding Protein Homologs.

    abstract::The precise localization of CaV2 voltage-gated calcium channels at the synapse active zone requires various interacting proteins, of which, Rab3-interacting molecule or RIM is considered particularly important. In vertebrates, RIM interacts with CaV2 channels in vitro via a PDZ domain that binds to the extreme C-termi...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evaa097

    authors: Piekut T,Wong YY,Walker SE,Smith CL,Gauberg J,Harracksingh AN,Lowden C,Novogradac BB,Cheng HM,Spencer GE,Senatore A

    更新日期:2020-08-01 00:00:00

  • Genetic Competence Drives Genome Diversity in Bacillus subtilis.

    abstract::Prokaryote genomes are the result of a dynamic flux of genes, with increases achieved via horizontal gene transfer and reductions occurring through gene loss. The ecological and selective forces that drive this genomic flexibility vary across species. Bacillus subtilis is a naturally competent bacterium that occupies ...

    journal_title:Genome biology and evolution

    pub_type: 杂志文章

    doi:10.1093/gbe/evx270

    authors: Brito PH,Chevreux B,Serra CR,Schyns G,Henriques AO,Pereira-Leal JB

    更新日期:2018-01-01 00:00:00