解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, focusing in particular on the recent resurgence of electron microscopy ...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687688.2016.1221533
更新日期:2016-03-01 00:00:00
abstract::Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687688.2016.1182652
更新日期:2015-08-01 00:00:00
abstract::4-Hydroxy-2-nonenal (4-HNE) is a reactive aldehyde and a lipid peroxidation product formed in biological tissues under physiological and pathological conditions. Its concentration increases with oxidative stress and induces deleterious modifications of proteins and membranes. Mitochondrial and cytosolic isoforms of cr...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2015.1023376
更新日期:2015-01-01 00:00:00
abstract::Membrane microdomains enriched in cholesterol, sphingolipids (rafts), and specific proteins are involved in important physiological functions. However their structure, size and stability are still controversial. Given that detergent-resistant membranes (DRMs) are in the liquid-ordered state and are rich in raft-like c...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2014.949319
更新日期:2014-09-01 00:00:00
abstract::Elucidating the detailed mechanism of activation of membrane protein receptors and their ligand binding is essential for structure-based drug design. Membrane protein crystal structure analysis successfully aids in understanding these fundamental molecular interactions. However, protein crystal structure analysis of t...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2014.923588
更新日期:2014-08-01 00:00:00
abstract::Amiodarone (AMI) is a low water-solubility drug, which is very useful in the treatment of severe cardiac disease. Its adverse effects are associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and prevent AMI toxicity. The aim of this work was to develop and characterize Dimyris...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2014.896956
更新日期:2014-03-01 00:00:00
abstract::Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membrane transport processes between membrane compartments, autophagy is modulated b...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2013.850178
更新日期:2013-12-01 00:00:00
abstract::Absorption of dietary fat in the small intestine involves epithelial exposure to potentially harmful molecules such as bile salts and free fatty acids. We used organ culture of porcine jejunal explants incubated with a pre-digested mixture of fat (plant oil), bile and pancreatin to mimick the physiological process of ...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2013.780642
更新日期:2013-05-01 00:00:00
abstract::Membrane proteins are intrinsically involved in both human and pathogen physiology, and are the target of 60% of all marketed drugs. During the past decade, advances in the studies of membrane proteins using X-ray crystallography, electron microscopy and NMR-based techniques led to the elucidation of over 250 unique m...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.710341
更新日期:2013-03-01 00:00:00
abstract::Solid-state NMR combined with sample deuteration was used to probe the proximity of the low-affinity substrate D-glucose to its binding site within the Escherichia coli sugar transport protein GalP. Samples of E. coli inner membranes with amplified expression of GalP were incubated in D(2)O with D-[(13)C(6)]glucose an...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.743193
更新日期:2013-03-01 00:00:00
abstract::The mitochondrial ADP/ATP carrier imports ADP from the cytosol into the mitochondrial matrix for its conversion to ATP by ATP synthase and exports ATP out of the mitochondrion to replenish the eukaryotic cell with chemical energy. Here the substrate specificity of the human mitochondrial ADP/ATP carrier AAC1 was deter...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.745175
更新日期:2013-03-01 00:00:00
abstract::The number of structures of integral membrane proteins from higher eukaryotes is steadily increasing due to a number of innovative protein engineering and crystallization strategies devised over the last few years. However, it is sobering to reflect that these structures represent only a tiny proportion of the total n...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2012.703703
更新日期:2013-02-01 00:00:00
abstract::A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2012.674162
更新日期:2012-11-01 00:00:00
abstract::Insolubility of membrane components in non-ionic detergents such as Triton X-100 at low temperature is a widely used biochemical criterion to identify, isolate and characterize membrane domains. In this work, we monitored the detergent insolubility of the serotonin(1A) receptor in CHO cell membranes and its modulation...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2012.688147
更新日期:2012-11-01 00:00:00
abstract::Equilibrative Nucleoside Transporters (SLC29) are a family of proteins that transport nucleosides, nucleobases and nucleoside analogue drugs across cellular membranes. ENT1 is expressed ubiquitously in mammalian tissues and responsible for a significant portion of nucleoside analog drug uptake in humans. Despite the i...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2011.604861
更新日期:2011-09-01 00:00:00
abstract::CitS of Klebsiella pneumoniae and GltS of Escherichia coli are Na+-dependent secondary transporters from different families that are believed to share the same fold and quaternary structure. A 10 kDa protein tag (Biotin Acceptor Domain [BAD]) was fused to the N-terminus of both proteins (CitS-BAD1 and GltS-BAD1, respe...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2011.581252
更新日期:2011-08-01 00:00:00
abstract::The transporter SbtA is a high affinity Na+-dependent HCO3- uptake system present in a majority of cyanobacterial clades. It functions in conjunction with CO2 uptake systems and other HCO3- uptake systems to allow cyanobacteria to accumulate high levels of HCO3- used to support efficient photosynthetic CO2 fixation vi...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2011.593049
更新日期:2011-08-01 00:00:00
abstract::We have previously shown that a mixture of cerebrosides obtained from dried tubers of herb Typhonium giganteum Engl. plays a neuroprotective role in the ischemic brain through its effect on activation of BK(Ca) channels. It is very curious to know whether a single pure cerebroside compound could activate the BK(Ca) ch...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2010.538731
更新日期:2011-02-01 00:00:00
abstract::The eukaryotic endomembrane system (ES) is served by hundreds of dedicated proteins. Experimental characterization of the ES-associated molecular machinery in several model eukaryotes complemented by a recent progress in phylogenomics and comparative genomics have revealed a conserved complex core of the machinery tha...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.521201
更新日期:2010-11-01 00:00:00
abstract::Radiation-based therapies aided by nanoparticles have been developed for decades, and can be primarily categorized into two main platforms. First, delivery of payload of photo-reactive drugs (photosensitizers) using the conventional nanoparticles, and second, design and development of photo-triggerable nanoparticles (...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.507788
更新日期:2010-10-01 00:00:00
abstract::Nanoparticles present a new collection of contrast agents for the field of in vivo molecular imaging. This review focuses on promising molecular imaging probes for optical and magnetic resonance imaging based on four representative nanomaterial(s) platforms: quantum dots, upconversion phosphors, superparamagnetic iron...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.481640
更新日期:2010-10-01 00:00:00
abstract::Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse bl...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2010.499548
更新日期:2010-08-01 00:00:00
abstract::Palmitoylation is required for the activities of several cancer-associated proteins, making the palmitoyl acyltransferase (PAT) enzymes that catalyze these reactions potential targets for anticancer therapeutics. In this study, we sought to identify and characterize a human PAT with activity toward N-terminally myrist...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687681003616854
更新日期:2010-04-01 00:00:00
abstract::Glucosyltransferases (Gtrs) and O-acetyltransferase (Oac) are integral membrane proteins embedded within the cytoplasmic membrane of Shigella flexneri. Gtrs and Oac are responsible for unidirectional host serotype conversion by altering the epitopic properties of the bacterial surface lipopolysaccharide (LPS) O-antige...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687680903552250
更新日期:2010-04-01 00:00:00
abstract::Small GTPase Rab36 is homologous to Rab34 with 56% amino acid sequence identity. Rab34 was characterized as a Golgi-associated Rab protein and regulates lysosomal positioning through interaction with RILP; however, the properties and functions of Rab36 have not been investigated. To investigate Rab36, we constructed E...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687680903417470
更新日期:2010-01-01 00:00:00
abstract::2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680903164101
更新日期:2009-08-01 00:00:00
abstract::Microorganisms that survive in natural environments form organized multicellular communities, biofilms and colonies with specific properties. During stress and nutrient limitation, slow growing and senescent cells in such communities retain vital processes by maintaining plasma membrane integrity and retaining the abi...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680902893130
更新日期:2009-05-01 00:00:00
abstract::PagP is a bacterial outer membrane protein consisting of an 8 stranded transmembrane beta-barrel and an N-terminal alpha-helix. It is an enzyme which catalyses transfer of a palmitoyl chain from a phospholipid to lipid A. Molecular dynamics simulations have been used to compare the dynamic behaviour in simulations sta...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680902788967
更新日期:2009-05-01 00:00:00
abstract::Numerous cell surface receptors propagate activation signals to the interior of the cell via tyrosine phosphorylation of transmembrane proteins. This leads to the phosphotyrosine (PiY)-mediated recruitment of cytoplasmic signalling protein complexes which catalyze crucial biochemical signalling reactions. Here we desc...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680802637660
更新日期:2009-04-01 00:00:00
abstract::Organellar and cytosolic pH homeostasis is central to most cellular processes, including vesicular trafficking, post-translational modification/processing of proteins, and receptor-ligand interactions. SLC9A7 (NHE7) was identified as a unique (Na+, K+)/H+ exchanger that dynamically cycles between the trans-Golgi netwo...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680802263046
更新日期:2008-08-01 00:00:00
abstract::Neurotransmitter receptor trafficking in and out synapses has emerged as a key process to regulate synaptic transmission during synaptic development and plasticity both at excitatory and inhibitory synapses. Lateral diffusion of surface neurotransmitter receptors has recently emerged as a key pathway to regulate recep...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687680801958364
更新日期:2008-05-01 00:00:00
abstract::Spontaneous membrane adsorption, folding and insertion of the synthetic WALP16 and KALP16 peptides was studied by computer simulations starting from completely extended conformations. The peptides were simulated using an unmodified all-atom force field in combination with an efficient Monte Carlo sampling algorithm. T...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680802020313
更新日期:2008-04-01 00:00:00
abstract::Dengue fever is one of the most widespread tropical diseases in the world. The disease is caused by a virus member of the Flaviviridae family, a group of enveloped positive sense single-stranded RNA viruses. Dengue virus infection is mediated by virus glycoprotein E, which binds to the cell surface. After uptake by en...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680701633091
更新日期:2008-02-01 00:00:00
abstract::The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural inf...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687680701388423
更新日期:2007-09-01 00:00:00
abstract::In Saccharomyces cerevisiae Jen1p is a lactate/proton symporter belonging to the lactate/pyruvate:H(+) symporter subfamily (TC#2.A.1.12.2) of the Major Facilitator Superfamily. We investigated structure-function relationships of Jen1p using a rational mutational analysis based on the identification of conserved amino ...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687680701342669
更新日期:2007-09-01 00:00:00
abstract::Glycosyl-phosphatidylinositol (GPI)-anchored proteins are enriched in cholesterol- and sphingolipid-rich lipid rafts within the membrane. Rafts are known to have roles in cellular organization and function, but little is understood about the factors controlling the distribution of proteins in rafts. We have used atomi...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860601127770
更新日期:2007-05-01 00:00:00
abstract::Ionotropic glutamate receptors belong to the superfamily of P-loop channels as well as K(+), Na(+), and Ca(2+) channels. However, the structural similarity between ion channels of the glutamate receptors and K(+) channels is a matter of discussion. The aim of this study was to analyze differences between the structure...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860601008806
更新日期:2007-03-01 00:00:00
abstract::In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti. PS externalization was unchanged by caspase inhibition, suggesting that externalization did not portend ap...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860600926883
更新日期:2007-01-01 00:00:00
abstract::ADP-ribosylation factor related protein 1 (ARFRP1) is a member of the ARF-family of GTPases which operate as molecular switches in the regulation of intracellular protein traffic. Deletion of the mouse Arfrp1 gene leads to embryonic lethality during early gastrulation, suggesting that ARFRP1 is required for cell adhes...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860600840100
更新日期:2006-11-01 00:00:00
abstract::Previous work from our laboratory has established bovine hippocampal membranes as a convenient natural source for studying neuronal receptors such as the G-protein coupled serotonin1A receptor. In this paper, we have explored the organization and dynamics of bovine hippocampal membranes using environment-sensitive and...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/09687860600803223
更新日期:2006-09-01 00:00:00